ACR Meeting Abstracts

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Abstracts tagged "adaptive immunity"

  • Abstract Number: 1422 • 2019 ACR/ARP Annual Meeting

    Reduction in CD4 TEMRA Cells and Its Association with DAS28 (CRP) < 2.6 Treatment Response with Abatacept in Patients with Early, ACPA+, DMARD-Naïve RA

    Paul Emery1, Yoshiya Tanaka 2, Vivian Bykerk 3, Clifton Bingham 4, Thomas Huizinga 5, Gustavo Citera 6, Sean Connolly 7, Kuan-Hsiang Gary Huang 7, Yedid Elbez 8, Sumanta Mukherjee 7 and Roy Fleischmann 9, 1Leeds Institute of Rheumatic and Musculoskeletal Medicine, Leeds, United Kingdom, 2University of Occupational and Environmental Health Japan, Kitakyushu, Japan, 3Hospital for Special Surgery, New York City, NY, 4Johns Hopkins University, Baltimore, MD, 5Leiden University Medical Center, Leiden, Netherlands, 6Instituto de Rehabilitación Psicofísica, Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina, 7Bristol-Myers Squibb, Princeton, NJ, 8Excelya, Boulogne-Billancourt, France, 9Metroplex Clinical Research Center and University of Texas Southwestern Medical Center, Dallas, TX

    Background/Purpose: T-cell profiles are heterogeneous between individuals and consist of naïve T cells, memory T cells (including effector memory T cells [TEM] and central memory…
  • Abstract Number: 1937 • 2019 ACR/ARP Annual Meeting

    Mononuclear Leukocyte DNA Methylome Imprinting of Networked Signaling and Immunity Regulatory Pathways in Gout

    Zengmiao Wang 1, Ying Zhao 1, Amanda Phipps-Green 2, Ru Liu-Bryan 3, Arnold Ceponis 1, David Boyle 4, Jun Wang 1, Tony Merriman 5, Wei Wang 4 and Robert Terkeltaub6, 1UCSD, La Jolla, CA, 2University of Otago, Otago, Otago, New Zealand, 3San Diego VA/UCSD, La Jolla, CA, 4University of California, San Diego, San Diego, CA, 5University of Otago, Birmingham, AL, 6San Diego VA/UCSD, San Diego, CA

    Background/Purpose: Gout encompasses acute arthritis flares mediated by innate autoinflammatory responses to urate crystals, chronic granulomatous tophi, and synovitis promoting bone erosion and soft tissue…
  • Abstract Number: 2747 • 2019 ACR/ARP Annual Meeting

    Identification of Naturally Presented Peptides of the Autoantigen Topoisomerase-I Reveals a Common Pathogenic Mechanism in Patients with Systemic Sclerosis

    Eleni Tiniakou1, Andrea Fava 2, Zsuzsanna McMahan* 3, Tara Gurh 4, Robert O'Meally 4, Ami Shah 5, Frederick Wigley 3, Robert Cole 4, Francesco Boin 6 and Erika Darrah 1, 1Johns Hopkins University, Baltimore, MD, 2Johns Hopkins University School of Medicine, Baltimore, MD, 3Johns Hopkins University, Division of Rheumatology, Baltimore, 4Johns Hopkins University, Baltimore, 5Johns Hopkins Hospital, Baltimore, MD, 6UCSF, San Francisco, CA

    Background/Purpose: Autoimmune responses to DNA topoisomerase-I (TOP1) are found in a subset of patients with scleroderma at high risk for interstitial lung disease (ILD) and…
  • Abstract Number: 91 • 2019 ACR/ARP Annual Meeting

    Histonedeacetylase 1 (HDAC1): A Key Mediator of T Cells for the Pathogenesis of Rheumatoid Arthritis

    Lisa Goschl 1, Victoria Saferding 1, Nicole Boucheron 2, Johan Backlund 3, Alexander Platzer 1, Kiyoshi Hirahara 4, Han-yu Shih 5, Patrick Matthias 6, Clemens Scheinecker 1, Günter Steiner 7, Wilfried Ellmeier 2 and Michael Bonelli1, 1Division of Rheumatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria, 2Institute of Immunology, Division of Immunobiology, Medical University of Vienna, Vienna, Austria, 3Medical Inflammation Research, Karolinska Institute; Department of Medical Biochemistry and Biophysics, Stockholm, Sweden, 4Graduate School of Medicine, Chiba University, Chiba, Japan, 5National Institute of Arthritis, National Institutes of Health, Bethesda, 6Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland, 7Division of Rheumatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria; Ludwig Boltzmann Institute for Arthritis and Rehabilitation, Vienna, Austria, Vienna, Austria

    Background/Purpose: Despite enormous efforts to develop new therapeutic strategies for treatment of rheumatoid arthritis (RA), the large number of non responding patients to currently available…
  • Abstract Number: 107 • 2019 ACR/ARP Annual Meeting

    Expanded Peripheral T Helper Cells Characterize the Early Rheumatoid Arthritis Synovium

    William Murray-Brown1, Yanxia Guo 2, Mihir Wechalekar 1, Helen Weedon 1, Malcolm Smith 1, Susanna Proudman 3, Navin Rao 4, Sunil Nagpal 4 and Mihir Wechalekar 1, 1Flinders University, Adelaide, Australia, 2Janssen Research, Spring House, 3Adelaide University, Adelaide, Australia, 4Janssen R&D, Spring House, PA

    Background/Purpose: Programmed cell death protein 1 (PD-1) expressing T-cells are implicated in the pathogenesis of autoimmune inflammatory diseases such as rheumatoid arthritis (RA). In secondary…
  • Abstract Number: 2042 • 2018 ACR/ARHP Annual Meeting

    Immunophenotypic Analysis of Tissue-Resident Memory T Cells in Rheumatoid Arthritis

    Seokchan Hong1, Jae Hyung Jung2, Jung Sun Lee3, Jae Bum Won1, Doo-Ho Lim4, Yong-Gil Kim1, Chang Keun Lee1 and Bin Yoo1, 1Division of Rheumatology, Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea, Republic of (South), 2Asan Institute for Life Science, Asan Medical Center, Seoul, Korea, Republic of (South), 3Division of Rheumatology, Department of Internal Medicine,, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea, Republic of (South), 4Division of Rheumatology, Department of Internal Medicine, University of Ulsan College of Medicine, Ulsan University Hospital, Ulsan, Korea, Republic of (South)

    Immunophenotypic analysis of tissue-resident memory T cells in rheumatoid arthritisSeokchan Hong1 Jae Hyung Jung1,2, Jung Sun Lee1, Jae Bum Won1, Doo-Ho Lim3, Yong-Gil Kim1, Chang-Keun…
  • Abstract Number: 2777 • 2018 ACR/ARHP Annual Meeting

    Dynamics in Peripheral Blood Cell Counts in Giant Cell Arteritis before Treatment, during Treatment and in Treatment-Free Remission

    Jacoba C. Graver1, Yannick van Sleen2, Wayel H. Abdulahad2, Annemieke M.H. Boots2, Maria Sandovici2 and Elisabeth Brouwer3, 1Rheumatoloy and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, 2Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, 3University of Groningen University Medical Center, Groningen, Netherlands

    Background/Purpose: Giant cell arteritis (GCA) is an inflammatory disease of large vessels requiring long-term treatment with glucocorticoids. The immunopathology is characterized by vessel infiltrating innate…
  • Abstract Number: 1793 • 2017 ACR/ARHP Annual Meeting

    Interleukin-17 Is Not a Determinant for the Pro- or Anti-Inflammatory Character of Interleukin-22 in Experimental Arthritis

    Debbie M. Roeleveld1, Loreto Parga Vidal2, Monique M. Helsen2, Birgitte Walgreen3, Bianka Marklein4, Karl Skriner5, Martin Hegen6, Peter L. van Lent2, Fons A.J. van de Loo2, Wim B. van den Berg2, Peter M. van der Kraan2 and Marije I. Koenders2, 1Experimental Rheumatology, Radboud University Medical Center, Nijmegen, Netherlands, 2Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands, 3Experimental, Radboud university medical center, Nijmegen, Netherlands, 4Humboldt University and Free University, Berlin, Germany, 5Department of Rheumatology and Clinical Immunology, Charité - University Medicine Berlin, Free University and Humboldt University Berlin, Berlin, Germany, 6Inflammation and Immunology Research Unit, Pfizer, Cambridge, MA

    Background/Purpose: High interleukin-22 (IL-22) levels are detected in serum and synovial fluid of rheumatoid arthritis (RA) patients and have been shown to positively correlate with…
  • Abstract Number: 1922 • 2017 ACR/ARHP Annual Meeting

    Cell Type Specific Gene Expression Analysis of Early Systemic Sclerosis Skin Shows a Prominent Activation Pattern of Innate and Adaptive Immune System in the Prospective Registry for Early Systemic Sclerosis (PRESS) Cohort

    Shervin Assassi1, Dinesh Khanna2, Monique Hinchcliff3, Virginia D. Steen4, Faye Hant5, Jessica K. Gordon6, Ami A. Shah7, Jun Ying8, William Swindell9, Wenjin Zheng10, Lisha Zhu10, Victoria K. Shanmugam11, Robyn T. Domsic12, Flavia V. Castelino13, Elana J. Bernstein14 and Tracy M. Frech15, 1University of Texas McGovern Medical School, Houston, TX, 2University of Michigan, Ann Arbor, MI, 3Rheumatology, Northwestern Medicine, Chicago, IL, 4Rheumatology, MedStar Georgetown University Hospital, Washington, DC, 5Medicine/Rheumatology & Immunology, Medical University of South Carolina, Charleston, SC, 6Rheumatology, Hospital for Special Surgery, New York, NY, 7Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, 8Department of Internal Medicine - Rheumatology, University of Texas McGovern Medical School, Houston, TX, 9Dermatology, University of Michigan - Ann Arbor, Ann Arbor, MI, 10University of Texas - School of Biomedical Informatics, Houston, TX, 11Rheumatology, The George Washington University, Washington, DC, 12Rheumatology, University of Pittsburgh, Pittsburgh, PA, 13Rheumatology, Harvard Medical School, Boston, MA, 14Rheumatology, Columbia University, New York, NY, 15Division of Rheumatology, University of Utah, Salt Lake City, UT

    Background/Purpose: To examine the global gene expression profile in patients with very early diffuse systemic sclerosis (SSc). Methods: Skin biopsies were obtained from patients enrolled…
  • Abstract Number: 3165 • 2016 ACR/ARHP Annual Meeting

    HLA-B27 Expression Is Accompanied By a Profoundly Altered IgA Response to the Intestinal Microbiota and Microbial Translocation to the Joint

    Mark Asquith1, Sean Davin1, Patrick Stauffer1, Claire Mitchell2 and James T. Rosenbaum1, 1Oregon Health & Science University, Portland, OR, 2Division of Arthritis and Rheumatology, Oregon Health & Science University, Portland, OR

    Background/Purpose:  HLA-B27 is the strongest known genetic risk factor for ankylosing spondylitis and other spondyloarthropathies (SpAs). We have shown previously that Fisher 344 rats that…
  • Abstract Number: 1165 • 2015 ACR/ARHP Annual Meeting

    Age-Dependent Effects of HLA-B27/β2m Expression on Host Immunity and the Intestinal Microbiota

    Mark Asquith1, Phoebe Lin2, Sean Davin3, Patrick Stauffer4, Stephen R. Planck5 and James T. Rosenbaum6, 1OHSU, Portland, OR, 2Casey Eye Institute, Oregon Health and Science University, Portland, OR, 3Oregon Health and Science University, Portland, OR, 4Oregon Health & Science University, Portland, OR, 5Casey Eye Institute, Oregon Health & Science University, Portland, OR, 6Devers Eye Institute, Legacy Hospital system, Portland, OR

    Background/Purpose: The HLA-B27/β2m transgenic rat is a leading model of Anklylosing Spondylitis (AS) and other B27-associated spondyloarthopathies. The development of both bowel and joint inflammation…
  • Abstract Number: 2999 • 2015 ACR/ARHP Annual Meeting

    Maternal Microchimerism Is Increased in Multiple Cellular Subsets of Patients with Systemic Sclerosis Compared to Healthy Controls

    Sami B. Kanaan1, Whitney Harrington2,3, Laurence S. Loubiere4, Tessa M. Aydelotte1 and J. Lee Nelson1,5, 1Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, 2Seattle Children's Hospital, Seattle, WA, 3Department of Pediatrics, University of Washington School of Medicine, Seattle, WA, 4University of Birmingham, Birmingham, United Kingdom, 5University of Washington, Seattle, WA

    Background/Purpose: Microchimerism (Mc) is naturally acquired through bi-directional exchange of small amounts of cells or DNA between mother and fetus during pregnancy. Higher amounts of…
  • Abstract Number: 2784 • 2014 ACR/ARHP Annual Meeting

    Contribution at the Spinal Level of Innate and Adaptive Immunity to the Development of Persistent Post-Inflammatory Mechanical Allodynia in Arthritic Mice

    Sarah Woller1, Cody Ocheltree2, Tony Yaksh1 and Marpiat Corr3, 1Anesthesiology, UCSD, La Jolla, CA, 2Division of Rheumatology, Allergy, and Immunology, UCSD, La Jolla, CA, 3University of California at San Diego, La Jolla, CA

    Background/Purpose Individuals with arthritis frequently develop persistent pain despite adequate treatment of synovitis. There is a need to better understand the mechanisms underlying pain occurring…
  • Abstract Number: 2714 • 2013 ACR/ARHP Annual Meeting

    Commensal Intestinal Microbiota Drives Spontaneous Interleukin-1- and T Helper 17-Mediated Arthritis In Mice

    Shahla Abdollahi-Roodsaz1, Rebecca Rogier2, Tom Ederveen2, Harm Wopereis3, Raish Oozeer3, Marije I. Koenders2 and Wim B. van den Berg1, 1Rheumatology Research and Advanced Therapeutics, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, 2Rheumatology Research and Advanced Therapeutics, Radboud University Nijmegen Medical Center, Nijmegen, Netherlands, 3Danone Research, Wageningen, Netherlands

    Background/Purpose: Altered composition of intestinal microbiota in recent-onset rheumatoid arthritis (RA) and possible efficacy of oral antibiotics suggest a role of intestinal microbiota in RA.…
  • Abstract Number: 1691 • 2013 ACR/ARHP Annual Meeting

    The STAT1 Signaling Pathway In Giant Cell Arteritis

    Bjorn Hartmann1, Joyce Liao2, Michael H. Weisman3, Kenneth J. Warrington4, Jorg J. Goronzy1 and Cornelia M. Weyand5, 1Medicine: Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA, 2Byers Eye Institute at Stanford, Stanford University, Palo Alto, CA, 3Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, 4Division of Rheumatology, Mayo Clinic, Rochester, MN, 5Medicine, Stanford University School of Medicine, Stanford, CA

    Background/Purpose: In giant cell arteritis (GCA), CD4 T cells, macrophages and multinucleated giant cells form granulomatous lesions in the walls of medium and large arteries.…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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