Abstracts tagged "adam17"

Abstract Number: 1487 • ACR Convergence 2021
Type I Interferon Modulates Langerhans Cell ADAM17 in Lupus to Contribute to Photosensitivity
Thomas Li¹, Keila Veiga², Noa Schwartz³, Jose Lora⁴, Yong Liu⁴, Ali Jabbari⁵, William Shipman¹, Mehdi Rashighi⁶, James Krueger⁷, Niroshana Anandasabapathy⁴, David Oliver⁸, Yurii Chinenov⁸, Carl Blobel¹ and Theresa Lu¹, ¹Hospital for Special Surgery, New York, NY, ²New York Medical College, Hawthorne, NY, ³Albert Einstein College of Medicine/Montefiore Medical Center, New York, NY, ⁴Weill Cornell Medicine, New York, NY, ⁵University of Iowa, Iowa City, IA, ⁶University of Massachusetts Medical School, Worcester, MA, ⁷Rockefeller University, New York, NY, ⁸David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY
Background/Purpose: Photosensitivity is a common feature in the autoimmune disease lupus erythematosus (LE) where patients develop inflammatory skin lesions in response to ultraviolet radiation (UVR).…
Abstract Number: 168 • 2020 Pediatric Rheumatology Symposium
Examining the Role of IFN-I and Langerhans Cell ADAM17 in Lupus Photosensitivity
Keila Veiga¹, Noa Schwartz ², William Shipman ¹, Marvin Sandoval ³, Thomas Li ¹, Yurii Chinenov ¹, David Oliver ¹, Ali Jabbari ⁴, James Krueger ⁵, Sarah Taber ¹, Niroshana Anandasabapathy ⁶ and Theresa Lu ¹, ¹Hospital for Special Surgery, New York, ²Albert Einstein College of Medicine/Montefiore Medical Center, New York, ³Weill Cornell Graduate School of Medical Sciences, New York, ⁴University of Iowa, Iowa City, ⁵Rockefeller Center, New York, ⁶Weill Cornell Medicine, New York
Background/Purpose: Photosensitivity resulting in inflammatory skin lesions is a hallmark of cutaneous lupus. Lesions can be disfiguring and have a negative impact on quality of…