ACR Meeting Abstracts

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Abstracts tagged "ACPA"

  • Abstract Number: 2565 • 2015 ACR/ARHP Annual Meeting

    ACPA Specific IVIG Attenuate Collagen Induced Arthritis in Mice

    Shaye Kivity1, Nina Svetliscky1, Qusim Odeh1, Smadar Gertel1, Howard Amital1, Omer Gendelman1, Iris Barshack2, Alexander Volkov2, Eran Bar-Meir3, Miri Blank1 and Yehuda Shoenfeld4, 1Sheba Medical Center, Zabludowicz Center for Autoimmune Diseases, affiliated to Sackler Faculty of Medicine, Tel-Aviv University, Ramat Gan, Israel, 2Sheba Medical Center, Institute of Pathology, affiliated to Sackler Faculty of Medicine, Tel-Aviv University, Ramat Gan, Israel, 3Plastic surgeon Poria Medical Center affiliated to Faculty of medicine in the Galilee Bar-Ilan university, Poria, Israel, 4Sheba Medical Center, Zabludowicz Center for Autoimmune Diseases, affiliated to affiliated to Sackler Faculty of Medicine, Tel-Aviv University, Ramat Gan, Israel

    Background/Purpose: Administration of intravenous-immunoglobulin (IVIg) is a recognized safe and efficient immunomodulatore therapy for many autoimmune diseases. Anti-idiotypic antibody binding to pathogenic autoantibodies was proposed…
  • Abstract Number: 520 • 2015 ACR/ARHP Annual Meeting

    Antibody to Porphyromonas Gingivalis in Pre-Clinical Rheumatoid Arthritis

    Brian Coburn1, Kevin D. Deane2, Jess D. Edison3, Geoffrey M. Thiele1, Michael J. Duryee4, Carlos D. Hunter4, Jeffrey Payne5, Fang Yu6, Harlan Sayles6, V. Michael Holers2, Jill M. Norris7, William R Gilliland8, Jeremy Sokolove9, WH Robinson9 and Ted R. Mikuls1, 1Omaha VA Medical Center and University of Nebraska Medical Center, Omaha, NE, 2Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO, 3Walter Reed National Military Medical Center, Bethesda, MD, 4Internal Medicine Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE, 5College of Dentistry, University of Nebraska Medical Center, Lincoln, NE, 6University of Nebraska Medical Center, Omaha, NE, 7Epidemiology, University of Colorado Denver, Aurora, CO, 8Rheumatology Service, Walter Reed National Military Medical Center, Bethesda, MD, 9VA Palo Alto Healthcare System and Stanford University, Palo Alto, CA

    Background/Purpose: Periodontitis (PD) has been implicated as an etiologic risk factor in rheumatoid arthritis (RA), an association that is speculated to be related to the…
  • Abstract Number: 2570 • 2015 ACR/ARHP Annual Meeting

    Comparative Analysis of Collagen-Antibody Induced Arthritis and the  Arthritis Inhibitory Potential of Specific ACPA in Two Mouse Subspecies Genetically Separated about One Million Years Ago

    Christina Grimm1, Bianka Marklein1, Zoltan Konthur2, Gerd Burmester1 and Karl Skriner1, 1Department of Rheumatology and Clinical Immunology, Charité - Universitätsmedizin Berlin, Berlin, Germany, 2Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Berlin, Germany

    Background/Purpose: Rheumatoid arthritis (RA) is believed to be induced by environmental, genetic and immunological factors. Monoclonal Anti-citrullinated protein/peptide autoantibodies (ACPA) target different citrullinated proteins years…
  • Abstract Number: 1738 • 2014 ACR/ARHP Annual Meeting

    Prominent Role of CCR6+ T Helper Cells in the Pathogenesis of ACPA+ Patients with Early RA

    Sandra M.J. Paulissen1, Jan Piet van Hamburg2, Nadine Davelaar2, Heleen Vroman3, Johanna MW Hazes4, P.H.P. de Jong5 and Erik Lubberts2, 1Rheumatology, Erasmus Medical Center, Rotterdam, Netherlands, 2Immunology, Erasmus MC, University Medical Center, Rotterdam, Netherlands, 3Rheumatology and Pulmonary Medicine, Erasmus MC, University Medical Center, Rotterdam, Netherlands, 4Rheumatology, Erasmus MC University Medical Center Rotterdam, Rotterdam, Netherlands, 5Department of Rheumatology, Erasmus University Medical Center, Rotterdam, Netherlands

    Background/Purpose: Presence of serum anti-citrullinated protein antibodies (ACPAs) in patients with rheumatoid arthritis (RA) predicts worse disease course and a more erosive disease. In the…
  • Abstract Number: 453 • 2014 ACR/ARHP Annual Meeting

    In a Periodontal Disease Cohort without RA, Indeterminate or Low-Positive Anti-CCP-2 Antibodies Are Associated with Multiple Distinct ACPA

    Jerry A. Molitor1, Bryan S. Michalowicz2, Ryan T. Demmer3, Jane H. Buckner4, Mark H. Wener5 and William H. Robinson6, 1Rheumatology, University of Minnesota, Minneapolis, MN, 2Department of Developmental and Surgical Sciences, University of Minnesota School of Dentistry, Minneapolis, MN, 3Epidemiology, Columbia Univ. Mailman School of Public Health, New York, NY, 4Benaroya Research Institute at Virginia Mason, Seattle, WA, 5Rheumatology & Lab Med, University of Washington, Seattle, WA, 6Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA

    Background/Purpose: Periodontal disease (PD) and RA share the risk factors HLA DR B1 shared epitope (SE) and tobacco exposure (TE). PD may represent a risk…
  • Abstract Number: 1465 • 2014 ACR/ARHP Annual Meeting

    Follicular Helper T Cells Control Autoimmunity through IL-21/IL-21 Receptor Interaction in RA Patients

    Shikha Singla1, Minzi Chen2, Jerry Pounds Jr.2, Omar Khan2, Jerald M. Zakem2, Kismet Collins2, Tamika Webb-Detiege2, William E. Davis2, Robert Quinet2 and Xin Zhang3, 1Rheumatology, Ochner Medical Center, New Orleans, LA, 2Rheumatology, Ochsner Medical Center, New Orleans, LA, 3Institute of Translational Research, Ochsner Medical Center, New Orleans, LA

    Background/Purpose Rheumatoid Arthritis (RA) is an autoimmune disease characterized by chronic inflammation of the synovium, causing progressive joint destruction and reduction in quality of life…
  • Abstract Number: 423 • 2014 ACR/ARHP Annual Meeting

    Circulating Anti-Citrullinated Peptide Antibodies and Cytokines As Biomarkers of Response to Disease-Modifying Antirheumatic Drugs Therapy in Early Rheumatoid Arthritis

    Mahmood MTM Ally1, Pieter Meyer2, Bridget Hodkinson3, Eustasius Musenge4, Gregory Tintinger2, Mohammed Tikly5 and Ronald Anderson1, 1University of Pretoria, Pretoria, South Africa, 2university of pretoria, pretoria, South Africa, 3Rheumatology, University of the Witwatersrand, Johannesburg, South Africa, 4University of Witwatersrand, Johannesburg, South Africa, 5Rheumatology Wits University, C H Baragwanath Hospital, Johannesburg, South Africa

    Background/Purpose Serial measurement of circulating anti-citrullinated peptide antibodies (ACPA) and cytokines is of potential importance in the management of patients with rheumatoid arthritis (RA). However,…
  • Abstract Number: 1476 • 2014 ACR/ARHP Annual Meeting

    A Dose Response Relationship Between Shared Epitope and ACPA Level: But Not All SE Alleles Are Created Equal

    Jeremy Sokolove1, Lauren J. Lahey1, Catriona Wagner2, Irene Smolik3, David B. Robinson4, Elizabeth D. Ferucci5, Marianna Newkirk6, Marvin Fritzler7, William H. Robinson8 and Hani El-Gabalawy9, 1VA Palo Alto Healthcare System and Stanford University, Palo Alto, CA, 2VA Palo Alto Heatlh Care System and Stanford University, Palo Alto, CA, 3Arthritis Center, University of Manitoba, Winnipeg, MB, Canada, 4Arthritis Centre, University of Manitoba, Winnipeg, MB, Canada, 5Division of Community Health Services, Alaska Native Tribal Health Consortium, Anchorage, AK, 6McGill University, Montreal, QC, Canada, 7Medicine, University of Calgary, Calgary, AB, Canada, 8VA Palo Alto Health Care System and Stanford University, Palo Alto, CA, 9University of Manitoba, Winnipeg, MB, Canada

    Background/Purpose:  Indigenous North American populations have high prevalence of seropositive RA.  The Cree/Ojibway population in Central Canada and the Alaska Native population have a high prevalence…
  • Abstract Number: 434 • 2014 ACR/ARHP Annual Meeting

    Characterization of Lung Inflammation in the Lungs of Early Rheumatoid Arthritis

    Gudrun Reynisdottir1, Vijay Joshua2, Aase Haj Hensvold2, Lars Klareskog3 and Anca I Catrina2, 1Medicine, Rheumatology Unit, Karolinska University Hospital, Karolinska Institutet,, Stockholm, Sweden, 2Medicine, Rheumatology Unit, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, 3Medicine, Rheumatology Unit, Karolinska University Hospital, Karolinska institutet, Stockholm, Sweden

    Background/Purpose We have previously demonstrated that lung abnormalities are present already at disease onset in ACPA positive RA patients. We aimed to further investigate lung…
  • Abstract Number: 1475 • 2014 ACR/ARHP Annual Meeting

    Porphyromonas Gingivalis and Bone Turnover Biomarkers in Rheumatoid Arthritis

    Manpreet Sethi1, Anand Dusad1, Harlan Sayles2, Geoffrey Thiele3, Jeffrey Payne4, Michael J. Duryee5, Bart Hamilton6 and Ted R. Mikuls7, 1Rheumatology, University of Nebraska Medical Center, Omaha, NE, 2Omaha VA Medical Center and University of Nebraska Medical Center, Omaha, NE, 3Int Med/Sec of Rheum/Immun, Omaha VA Medical Center and University of Nebraska Medical Center, Omaha, NE, 4College of Dentistry, University of Nebraska Medical Center, Lincoln, NE, 5Internal Medicine Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE, 6University of Nebraska Medical Centre and Omaha VA Medical Center, Omaha, NE, 7Veteran Affairs Nebraska Western Iowa Health Care System and University of Nebraska Medical Center, Omaha, NE

    Background/Purpose: Periodontitis (PD) associated with P. gingivalis has been implicated as a risk factor for rheumatoid arthritis (RA).  We have previously demonstrated that RA patients…
  • Abstract Number: 433 • 2014 ACR/ARHP Annual Meeting

    Bronchiectasis: A Model for Chronic Bacterial Infection Inducing Autoimmunity in Rheumatoid Arthritis

    Anne-Marie Quirke1, Elizabeth Perry2, Alison Cartwright1, Clive Kelly3, Anthony De Sozya4,5, Paul Eggleton6, David Hutchinson2 and Patrick Venables7, 1Kennedy Institute, Nuffield Department of Orthopaedics, Rheumatology & Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom, 2Rheumatology, Royal Cornwall Hospital, Truro, United Kingdom, 3Rheumatology, Queen Elizabeth Hospital, Gateshead, United Kingdom, 4Institute for Cellular Medicine, Newcastle University, Newcastle, United Kingdom, 5Sir William Leech Centre, The Freeman Hospital, Newcastle, United Kingdom, 6Medical School, University of Exeter, Exeter, United Kingdom, 7Kennedy Institute of Rheumatology, University of Oxford, Oxford, United Kingdom

    Background/Purpose Anti-citrullinated peptide antibodies (ACPA) are associated with smoking in patients with rheumatoid arthritis (RA). Bronchiectasis (BR), which tends to occur in non-smokers, has been…
  • Abstract Number: 1433 • 2014 ACR/ARHP Annual Meeting

    Clinical Characterization of Subclinical Rheumatoid Arthritis-Associated Interstitial Lung Disease

    Masaomi Yamasaki, Rheumatology, Shin-Yokohama Yamasaki Clinic, Yokohama, Japan

    Background/Purpose Rheumatoid arthritis-associated interstitial lung disease (RA-ILD) is a common manifestation of rheumatoid lung disease.  Subclinical RA-ILD is most commonly identified on HRCT imaging. In…
  • Abstract Number: 408 • 2014 ACR/ARHP Annual Meeting

    14-3-3η Auto-Antibody Positivity Informs Better Clinical Outcomes in RA

    D. van Schaardenburg1, Mairead Murphy2, Samina Turk3, Walter P. Maksymowych4 and Anthony Marotta5, 1Jan van Breemen Research Institute, Amsterdam, Netherlands, 2Augurex Life Sciences Corp., North Vancouver, BC, Canada, 3Reade, Amsterdam, Netherlands, 4University of Alberta, Edmonton, AB, Canada, 51423 Dempsey Road, Augurex Life Sciences Corp., North Vancouver, BC, Canada

    Background/Purpose We have previously reported pilot data that patients who are only positive for 14-3-3η auto-antibodies (AAb) and negative for the 14-3-3η protein have a…
  • Abstract Number: 1248 • 2014 ACR/ARHP Annual Meeting

    Serologic and Clinical Overlap Between Sarcoidosis and the Rheumatic Autoimmume Diseases

    Sabrina Qazi1 and Marie Claire Maroun2, 1Internal Medicine-Rheumatology, Wayne State University, Detroit, MI, 2Rheumatology, Wayne State University, Detroit, MI

    Background/Purpose Sarcoidosis is a systemic inflammatory disorder of unknown etiology, characterized pathologically by noncaseating epithelioid cell granulomas, primarily affecting the lungs, the eye, the skin,…
  • Abstract Number: 370 • 2014 ACR/ARHP Annual Meeting

    Double Positivity of RA Serologies More Prevalent Yet Associated with Clinical Response in Ethnic Minority Patients with Rheumatoid Arthritis

    Mercedes Quinones1, Sharon Dowell2, Ignacio Garcia-Valladares3, Gail S. Kerr4, Christopher Swearingen5, Luis R. Espinoza6, Yusuf Yazici7, Edward L. Treadwell8, Theresa Lawrence Ford9, Yvonne Sherrer10, Angelia Mosley-WIlliams11, Rodolfo Perez Alamino12, Chunqiao Luo13, Akgun Ince14, Adrian Godoy2 and John Amatruda15, 1Division of Rheumatology, Howard University Hospital, Washington, DC, 2Division of Rheumatology, Howard University, Washington, DC, 3Immunology and Rheumatology, Hospital General de Occidente, Zapopan, Jal., Mexico, 4Rheumatology, Washington DC VAMC, Georgetown and Howard University, Washington, DC, 5Pediatrics and Biostatistics, University of Arkansas, Little Rock, AR, 6Medicine-Section of Rheum, LSU Medical Center, New Orleans, LA, 7Department of Medicine, Division of Rheumatology, New York University School of Medicine, New York, NY, 8Dept Medicine Div of Rheum, East Carolina University, Greenville, NC, 9North Georgia Rheumatology Group, PC, Lawrenceville, GA, 10Rheum/Immunology, Centre Rheum Immunol Arthritis, Fort Lauderdale, FL, 11Rheumatology, Detroit VAMC, Detroit, MI, 12internal Medicine, LSUHSC, New Orleans, LA, 13University of Arkansas for Medical Sciences, Little Rock, AR, 14Arthitis Consultants Inc, St. Louis University, St. Louis, MO, 15Rheumatology, Howard University, Washington, DC

    Double Positivity of RA Serologies More Prevalent But Associated with Clinical Response in a Diverse Ethnic Cohort with Rheumatoid ArthritisBackground/Purpose:  The presence of both the…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

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