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Abstracts tagged "abatacept and biomarkers"

  • Abstract Number: 1381 • 2019 ACR/ARP Annual Meeting

    High Serum IgA and High Proportion of Activated Th17 and Activated Treg Cells Are Predictive Biomarkers for Remission Achievement with Abatacept in Patients with Early, Seropositive Rheumatoid Arthritis

    Jun Inamo1, Yuko Kaneko 2, Jun Kikuchi 3 and Tsutomu Takeuchi 4, 1Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Tokyo, Japan, 2Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Shinjuku, Tokyo, Japan, 3Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan, 4Keio University School of Medicine, Tokyo, Japan

    Background/Purpose: Abatacept (ABT) is a soluble fusion protein, which links cytotoxic T-lymphocyte-associated protein 4 to the modified Fc portion of IgG1. Seropositivity and a shorter…
  • Abstract Number: 1390 • 2019 ACR/ARP Annual Meeting

    Prediction of Clinical Response to Abatacept in Rheumatoid Arthritis Patients Through the Determination of Anti-Carbamylated Proteins Antibodies Levels

    Silvia Piantoni1, Michele Boldini 1, Rajesh Kumar 1, Emirena Garrafa 1, Chiara Bazzani 2, Micaela Fredi 3, Ilaria Cavazzana 1, Angela Tincani 3 and Franco Franceschini 3, 1ASST Spedali Civili and University of Brescia, Brescia, Italy, 2Rheumatology and Clinical Immunology, Spedali Civili, Brescia, Italy, Brescia, Italy, 3Rheumatology and Clinical Immunology, Spedali Civili and Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy, Brescia, Italy

    Background/Purpose: Carbamylation is a non-enzymatic irreversible post-translational modification of proteins. The presence of anti-carbamylated protein antibodies (anti-CarP) has been observed in rheumatoid arthritis (RA). In…
  • Abstract Number: 2067 • 2015 ACR/ARHP Annual Meeting

    De-Convolution of Whole Blood Transcriptomic Data from a Phase IIb, Randomized, Double-Blind, Placebo-Controlled Trial of Abatacept in Systemic Lupus Erythematosus

    S Bandyopadhyay1, SE Connolly1, O Jabado1, S Kelly1, M Maldonado1, R Westhovens2, P Nash3, JT Merrill4 and R Townsend1, 1Bristol-Myers Squibb, Princeton, NJ, 2University Hospitals KU Leuven, Leuven, Belgium, 3University of Queensland, Brisbane, Australia, 4Oklahoma Medical Research Foundation, Oklahoma City, OK

    Background/Purpose: The Phase IIb IM101-042 trial was a randomized, double-blind, placebo-controlled trial of abatacept (ABA) in systemic lupus erythematosus patients (pts) with polyarthritis, discoid lesions…
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