Simple Search Results

Didn't find what you were looking for? Try the Advanced Search »

Search Again »

Abstract Number: 2463 • 2014 ACR/ARHP Annual Meeting
Stromal Cell Markers Are Differentially Expressed in the Synovial Tissue of Patients with Early Arthritis
Ivy Y.K. Choi¹, Olga N. Karpus², Jason D. Turner³, Debbie L. Hardie³, Maria J. H. de Hair¹, Karen I. Maijer¹, Paul-Peter Tak^1,4,5, Karim Raza^3,6, Jörg Hamann², Christopher Buckley³, Danielle Marie Gerlag^1,7 and Andrew Filer^3,8, ¹Division of Clinical Immunology and Rheumatology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands, ²Department of Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands, ³Rheumatology Research Group, MRC Centre for Immune Regulation, School of Immunity and Infection, University of Birmingham, Birmingham, United Kingdom, ⁴GlaxoSmithKline, Stevenage, United Kingdom, ⁵University of Cambridge, Cambridge, United Kingdom, ⁶Sandwell and West Birmingham Hospitals NHS Trust, Birmingham, United Kingdom, ⁷GlaxoSmithKline, Cambridge, United Kingdom, ⁸University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom
Background/Purpose Previous studies have shown increased expression of stromal markers in synovial tissue (ST) of patients with established rheumatoid arthritis (RA). Here, the expression of…
Abstract Number: 2307 • 2014 ACR/ARHP Annual Meeting
Cardiovascular Disease Prevention in Rheumatologic Disease: Assessing Screening in a Primary Care Setting
Micaela Bayard¹ and Magdalena Cadet², ¹Rheumatology, New York Hospital of Queens/ Weill Cornell Medical Center, New York, NY, ²Rheumatology and Immunology, Duke University School of Medicine, Durham, NC
Background/Purpose: To determine the proportion of patients diagnosed with rheumatologic disease receiving preventive health care according to US Preventive Services Task Force recommendations with emphasis…
Abstract Number: 2176 • 2014 ACR/ARHP Annual Meeting
Macrophages-Mediated Response to Uric Acid Crystals Is Modulated By Their Functional Polarization
Emma Garcia-Melchor¹, Monica Guma², Jordi Yagüe¹, Manel Juan¹ and Jacquie Harper³, ¹Immunology Department, Hospital Clinic Barcelona, Barcelona, Spain, ²Division of Rheumatology, Allergy and Immunology, University of California, San Diego, La Jolla, CA, ³Arthritis and Inflammation Group, Malaghan Institute of Medical Research, Wellington, New Zealand
Background/Purpose: Macrophages have been involved in both initiation and resolution of gout flares. Accordingly, these cells are characterized by their plasticity as the environment modulates…
Abstract Number: 2107 • 2014 ACR/ARHP Annual Meeting
Characterization of Social Stigma in Rheumatic Diseases and Correlation with Quality of Life and Medication Adherence
Gihyun Myung^1,2, Nancy D. Harada^3,4, Stephanie L. Fong¹, Cleopatra Aquino-Beaton^1,5 and Meika A Fang⁶, ¹VA Greater Los Angeles Healthcare System, Los Angeles, CA, ²Cedars-Sinai Medical Center, Los Angeles, CA, ³UCLA David Geffen School of Medicine, Long Beach, CA, ⁴VA Office of Academic Affiliations, Long Beach, CA, ⁵UCLA School of Nursing, Los Angeles, CA, ⁶Rheumatology, VA Greater Los Angeles Healthcare System, Los Angeles, CA
Background/Purpose Patients with rheumatoid arthritis and other rheumatic conditions may have physical deformities and functional limitations which make them vulnerable to health-related stigma. The objectives…
Abstract Number: 1875 • 2014 ACR/ARHP Annual Meeting
Can Allopurinol Survival Impact Reverse Depending on Patients’ Characteristics? a Propensity-Score-Based Subgroup Analysis
Na Lu¹, Hyon K. Choi², Maureen Dubreuil^3,4, Qiong Louie-Gao⁵ and Yuqing Zhang¹, ¹Boston University School of Medicine, Boston, MA, ²Division of Rheumatology, Allergy, and Immunology Massachusetts General Hospital, Harvard Medical School, Boston, MA, ³Rheumatology, Boston University Medical Center, Boston, MA, ⁴Rheumatology, Boston VA HealthCare System, Boston, MA, ⁵Clinical Epidemiology Research & Training Unit, Boston University School of Medicine, Boston, MA
Background/Purpose: Several studies have reported that allopurinol use is associated with a decreased risk of death or cardiovascular outcomes. While these studies reported the overall…
Abstract Number: 1834 • 2014 ACR/ARHP Annual Meeting
Uptake of the American College of Rheumatology’s (ACR) Rheumatology Clinical Registry (RCR): Quality Measure Summary Data
Natalie Fisk¹, Melissa Francisco², Jinoos Yazdany³ and Salahuddin Kazi⁴, ¹Registry, American College of Rheumatology, Atlanta, GA, ²American College of Rheumatology, Atlanta, GA, ³Medicine, University of California, San Francisco, San Francisco, CA, ⁴Internal Medicine/Rheumatology, UT Southwestern Medical Center, Dallas, TX
Background/Purpose: The RCR is designed to provide ACR members with an infrastructure for quality reporting related to rheumatoid arthritis, gout, osteoarthritis, osteoporosis, and drug safety.…
Abstract Number: 1686 • 2014 ACR/ARHP Annual Meeting
DUAL Energy Computed Tomography for the Evaluation of Calcinosis in Systemic Sclerosis
Vivien Hsu¹, Mark Bramwit² and Naomi Schlesinger³, ¹Rheumatology, RWJ Med Schl Scleroderma Prog, New Brunswick, NJ, ²Radiology, Robert Wood Johnson University Hospital, New Brunswick, NJ, ³Rutgers-Robert Wood Johnson Medical School, New Brunswick, NJ
Background/Purpose: To better characterize the soft tissue details of systemic sclerosis--related (SSc) calcinosis of the hands using dual-energy computer tomography (DECT). DECT is an imaging…
Abstract Number: 1516 • 2014 ACR/ARHP Annual Meeting
TNF-Alpha Inhibitors Normalizes Melanocortin Receptor Subtype 2, 3 and 4 Expression in CD8+, CD14+ and CD19+ Leukocyte Subsets in Rheumatoid Arthritis
Marlene Andersen¹, Michael Kruse Meyer², Ivan Nagaev³, Olga Nagaeva³, Jarl E.S. Wikberg⁴, Lucia Mincheva-Nilsson³ and Grethe N. Andersen², ¹Department of Rheumatology, Aalborg University, Hjørring, Denmark, ²Clinic of Rheumatology, Hospital of Vendsyssel/Aalborg University, Hjørring, Denmark, ³Department of Clinical Immunology, University of Umeå, Umeå, Sweden, ⁴Department of Pharmaceutical Biosciences, Department of Pharmaceutical Pharmacology, Uppsala, Sweden
Background/Purpose: We examined Adalimumab´s effects on melanocortin receptor subtype (MC)1-5 gene expression in important leukocyte subsets in rheumatoid arthritis (RA). The melanocortin system is a…
Abstract Number: 1446 • 2014 ACR/ARHP Annual Meeting
Utility of Ultrasound in the Nuffield Orthopaedic Centre Emergency Rheumatology Clinic: Survey of Clinical Effectiveness
Kuljeet Bhamra¹, Catherine Swales¹, Matthew Seymour¹, Catherine McClinton¹ and Peter C. Taylor², ¹Nuffield Department of orthopaedics,rheumatology and musculosketal sciences, University of Oxford, Oxford, United Kingdom, ²NDORMS, Botnar Research Centre, University of Oxford, Oxford, United Kingdom
Background/Purpose The aim of the survey was to evaluate the impact of clinic-based musculoskeletal ultrasonography (MSUS) on diagnosis and management of cases seen in the…
Abstract Number: 1224 • 2014 ACR/ARHP Annual Meeting
Pegloticase for Tophus Debulking: Comparison of Dual Energy Computerized Tomography (DECT), Musculoskeletal Ultrasound (MSK-US) and Topographic Caliper Measurement for Assessing Debulking Rate
Dodji Modjinou¹, Elaine Karis², Soterios Gyftopoulos³, Jonathan Samuels⁴, Robert T. Keenan⁵, Daisy Bang⁶, Kristen Lee⁴, Svetlana Krasnokutsky-Samuels⁷, Daria B. Crittenden⁸ and Michael H. Pillinger⁸, ¹Internal Medicine/Rheumatology, NYU/HJD, New York, NY, ²pending, pending, NY, ³Radiology, NYU Langone Medical Center/NYU Hospital for Joint Diseases, New York, NY, ⁴Rheumatology, NYU Langone Medical Center, New York, NY, ⁵Rheumatology, Duke University, Durham, NC, ⁶Division of Rheumatology, NYU School of Medicine, New York, NY, ⁷Rheumatology, NYU School of Medicine, New York, NY, ⁸NYU School of Medicine, Division of Rheumatology, New York, NY
Background/Purpose: Pegloticase is approved for lowering serum urate (sUA) in chronic refractory tophaceous gout (CRTG), but the rate of tophus resolution is not well defined,…
Abstract Number: 1223 • 2014 ACR/ARHP Annual Meeting
Enhancement of Proinflammatory Cytokine Production By Uric Acid in Human Cells Via Down Regulation of IL-1Ra
Tania Crisan¹, Maartje Cleophas², Heidi Lemmers³, Helga Toenhake-Dijkstra¹, Mihai Netea¹, Tim Jansen⁴ and Leo Joosten¹, ¹Internal Medicine, Radboud University Medical Center, Nijmegen, Netherlands, ²Internal Medicine, Radboud Unversity Medical Center, Nijmegen, Netherlands, ³Internal Medicine, Radboud Univeristy Medical Center, Nijmegen, Netherlands, ⁴Rheumatology, Radboud University Medical Center, Nijmegen, Netherlands
Background/Purpose Gout is an autoinflammatory disease characterized by the deposition of monosodium urate (MSU) crystals in the joints of hyperuricaemic patients and subsequent attacks of…
Abstract Number: 1222 • 2014 ACR/ARHP Annual Meeting
Suppressive Effect of Butyrate on Monosodium Urate (MSU) Crystal-Induced IL-1beta Production Is Mediated Via Inhibition of Class I Histone Deacetylases
Maartje Cleophas¹, Tania Crisan², Heidi Lemmers³, Helga Toenhake-Dijkstra², Gianluca Fossati⁴, Tim Jansen⁵, Charles Dinarello⁶, Mihai Netea² and Leo Joosten², ¹Internal Medicine, Radboud Unversity Medical Center, Nijmegen, Netherlands, ²Internal Medicine, Radboud University Medical Center, Nijmegen, Netherlands, ³Internal Medicine, Radboud Univeristy Medical Center, Nijmegen, Netherlands, ⁴Department of Preclinical Research and Development, Italfarmaco, Cinisello Balsamo, Italy, ⁵Rheumatology, Radboud University Medical Center, Nijmegen, Netherlands, ⁶Department of Medicine, Division of Infectious Diseases, University of Colorado, Denver, CO
Background/Purpose Gouty arthritis is triggered by endogenously formed monosodium urate (MSU) crystals. MSU crystals alone are unable to induce cytokine production and therefore a second…
Abstract Number: 1206 • 2014 ACR/ARHP Annual Meeting
Low Dose Colchicine Anti-Inflammatory Effects Are Transduced By AMP-Activated Protein Kinase (AMPK)
Ru Bryan¹, Robert Terkeltaub² and Yun Wang³, ¹Medicine-Rheumatology, VA Medical Center/University of California San Diego, San Diego, CA, ²Medicine-Rheumatology, VA Medical Ctr/University of California San Diego, San Diego, CA, ³Medicine-Rheumatology, VA Medical Ctr/UCSD, San Diego, CA
Background/Purpose AMPK is a master metabolic energy regulator, whose tissue activity drops in response to nutritional excesses, alcohol consumption, and in obesity, metabolic syndrome and…
Abstract Number: 1218 • 2014 ACR/ARHP Annual Meeting
The Reduction of Serum Uric Acid Level Might Prevent Atherosclerosis in Mice
Yoshitaka Kimura^1,2, Tamiko Yanagida³, Akiko Onda⁴, Hajime Kono², Maki Takayama², Kurumi Asako², Akiko Okamoto², Hirotoshi Kikuchi² and Toshihiro Nanki⁵, ¹Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan, ²Department of Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan, ³Depart ment of Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan, ⁴Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan, ⁵Department of Clinical Research Medicine, Teikyo University, Tokyo, Japan
Background/Purpose: Excess amount of uric acid in human body causes acute inflammation, gout. In addition, uric acid is identified as a danger signal and is…
Abstract Number: 1197 • 2014 ACR/ARHP Annual Meeting
Febuxostat Inhibits Monosodium Urate Crystal-Induced IL-1beta Secretion and Cell Death Via ROS- and Intracellular ATP-Dependent Pathways
Johji Nomura¹, Nathalie Busso², Mizuho Tamura¹, Tsunefumi Kobayashi¹ and Alexander So³, ¹Pharmaceutical Development Research Laboratories, Teijin Institute for Bio-Medical Research, Teijin Pharma Limited, Tokyo, Japan, ²Centre Hospitalier Universitaire Vaudois, University of Lausanne, Lausanne, Switzerland, ³Rheumatology, Centre Hospitalier Universitaire Vaudois, University of Lausanne, Lausanne, Switzerland
Background/Purpose: In gout, monosodium urate (MSU) crystals trigger acute inflammation. MSU has been reported to activate NLRP3 inflammasome via ROS-dependent pathways, which result in IL-1beta…

Search Again »

Didn't find what you were looking for? Try the Advanced Search »

All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].