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Abstract Number: 2720 • 2019 ACR/ARP Annual Meeting
Implementation of an Evidence-based Transition Clinic in a Pediatric Rheumatology Academic Institution
Rebecca Overbury¹, John Bohnsack ², CJ Inman ³, Sara Stern ³, Karen James ³, Daniel Clegg ³, Tracy Frech ⁴ and Aimee Hersh ³, ¹Assisstant Professor, University of Utah, Salt Lake City, UT, ²University of Utah School of Medicine, Salt Lake City, UT, ³University of Utah, Salt Lake City, UT, ⁴Division of Rheumatology, University of Utah and Salt Lake VAMC, Salt Lake City, UT
Background/Purpose: Transition from pediatric to adult rheumatology care is more likely to be successful if a transition program is in place. Previously successful interventions to…
Abstract Number: 2837 • 2019 ACR/ARP Annual Meeting
Asymptomatic Monosodium Urate Crystal Deposition Associates with Increased Expression of Pro-Inflammatory Genes
Gabriela Sandoval-Plata¹, Kevin Morgan ², Tamar Guetta-Baranes ², Ana Valdes ³, Michael Doherty ⁴ and Abhishek Abhishek ⁵, ¹Human Genomics and Molecular Genetics, School of Life Sciences, University of Nottingham / Academic Rheumatolog, School of Medicine, University of Nottingham, Nottingham, England, United Kingdom, ²Human Genomics and Molecular Genetics, School of Life Sciences, University of Nottingham, Nottingham, England, United Kingdom, ³Academic Rheumatology, School of Medicine, University of Nottingham / Nottingham NIHR BRC, Nottingham UK, Nottingham, England, United Kingdom, ⁴Academic Rheumatology, Division of Rheumatology,School of Medicine, University of Nottingham, Nottingham, UKArthritis Research UK Pain Centre, Nottingham, UKNational Institute for Health Research, Nottingham Biomedical Research Centre, Nottingham, UK, Nottingham, England, United Kingdom, ⁵Academic Rheumatology, School of Medicine, University of Nottingham,Nottingham,UK National Institute for Health Research, Nottingham Biomedical Research Centre, Nottingham,UK, Nottingham, England, United Kingdom
Background/Purpose: Persistent hyperuricaemia is a prerequisite for gout. However, only 10% of people with hyperuricaemia develop symptomatic gout, whereas 25-35% have asymptomatic monosodium urate (MSU)…
Abstract Number: 234 • 2018 ACR/ARHP Annual Meeting
Population-Based Estimates of Fatigue Prevalence Among Adults Aged >18 Years with and without Arthritis, United States, 2015-2016
Jennifer M. Hootman¹, Louise Murphy¹, Michael Boring¹ and Dana Guglielmo², ¹Arthritis Program, Centers for Disease Control and Prevention, Atlanta, GA, ²Oak Ridge Institute for Science and Education, Oak Ridge, TN
Background/Purpose: Fatigue is a common symptom among adults with arthritis and can severely impact quality-of life. This study’s two objectives were to estimate the national…
Abstract Number: 354 • 2018 ACR/ARHP Annual Meeting
Rheumatic Complications of Immune Checkpoint Inhibitor Therapy: A Single Center Experience
Mazen Nasrallah¹, Meghan Mooradian², Eli Miloslavsky³, Justine Cohen², Justin Gainor², Donald Lawrence², Kerry Reynolds², Minna Kohler⁴, Ryan Sullivan² and Sara Schoenfeld¹, ¹Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ²Division of Hematology and Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ³Division of Rheumatology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ⁴Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA
Background/Purpose: Immune checkpoint inhibitors (ICIs) have led to improved outcomes in multiple cancers, but they are associated with immune-related adverse events (irAEs), including inflammatory arthritis.…
Abstract Number: 433 • 2018 ACR/ARHP Annual Meeting
Impact of Bariatric Surgery on Rheumatic Diseases: A Systematic Review and Meta-Analysis
Marie Moly¹, Bernard Combe¹, Thomas Barnetche², Claire Daien¹, Jacques Morel³, Cédric Lukas¹, Cécile Gaujoux-Viala⁴ and Charlotte Hua⁴, ¹Rheumatology, University Hospital Lapeyronie, Montpellier, Montpellier, France, ²Rheumatology, University Hospital Pellegrin, Bordeaux, Bordeaux, France, ³Department of Rheumatology, University Hospital Lapeyronie, Montpellier, Montpellier, France, ⁴Rheumatology, University Hospital Carémeau , Nimes, Nimes, France
Background/Purpose: Obesity increase the incidence of rheumatic diseases (1-3). Bariatric surgery (BS) improve obesity-related comorbidities (4). The aim of our study was to assess currently…
Abstract Number: 871 • 2018 ACR/ARHP Annual Meeting
Estimates of Diet Quality Explain Less Variability in Serum Urate Levels Than Genetic Factors
Tanya J. Major¹, Ruth Topless¹, Nicola Dalbeth² and Tony R. Merriman¹, ¹University of Otago, Dunedin, New Zealand, ²University of Auckland, Auckland, New Zealand
Background/Purpose: Hyperuricaemia (elevated serum urate) is a central risk factor for gout, an acute inflammatory form of arthritis. The balance between the hepatic production of…
Abstract Number: 1151 • 2018 ACR/ARHP Annual Meeting
Comparison of Methodologic Approaches to Maximize the Validity of Fitbit Device Data for Arthritis-Related Research Purposes
Jeffrey R. Curtis¹, Shuo Yang¹, Lang Chen¹, Nada Elmagboul¹, David T. Redden², Amy S. Mudano¹, Phillip J. Foster³, Filby Cooper¹, Ted R. Mikuls⁴, Justin K Owensby¹ and Kenneth Saag⁵, ¹University of Alabama at Birmingham, Birmingham, AL, ²Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL, ³Department of Medicine, Division of Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ⁴Internal Medicine, Division of Rheumatology, VA Nebraska-Western Iowa Health Care System and University of Nebraska Medical Center, Omaha, NE, ⁵UAB, Birmingham, AL
Background/Purpose: Health activity tracker devices (e.g. Fitbit) are increasingly used component of medical evaluation. However, the validity and suitability of the data from such devices…
Abstract Number: 1201 • 2018 ACR/ARHP Annual Meeting
Finger Extensor Tendon Involvement Is Frequent in Early Rheumatoid Arthritis
Mihaela Maruseac¹, Patrick Durez^2,3, Adrien Nzeusseu Toukap⁴ and Maria Stoenoiu⁵, ¹Rheumatology, Cliniques Universitaires Saint-Luc, Brussels, Belgium, ²Pôle de Maladies Rhumatismales, Institut de Recherche Expérimentale et Clinique, Université catholique de Louvain, Brussels, Belgium, ³Pôle de Recherche en Rhumatologie, Institut de Recherche Expérimentale et Clinique, Université Catholique de Louvain, Brussels, Belgium, ⁴Department of Rheumatology, Rheumatology - Cliniques universitaires Saint-Luc - Université Catholique de Louvain - Institut de Recherche Expérimentale et Clinique (IREC), Brussels, Belgium, ⁵Rheumatology, Cliniques Universitaires Saint-Luc, Institut de Recherche Expérimentale et Clinique (IREC), Brussels, Belgium
Background/Purpose: Finger extensor involvement (FET) at ultrasound examination (US) was previously described in patients suffering from early psoriatic arthritis. Contradictory results were published in patients…
Abstract Number: 1202 • 2018 ACR/ARHP Annual Meeting
Tenosynovial Aspiration By Ultrasound Guidance: Even Small Volumes Can Have a Big Impact
Fawad Aslam¹, Amy C. Cannella², Veronika Sharp³, Lily Kao⁴, Jon Arnason⁵, Jemima Albayda⁶, Catherine Bakewell⁷, Shruti B Sanghvi⁸, Robert Fairchild⁹, Karina Torralba¹⁰, Amy M. Evangelisto¹¹, Paul DeMarco¹² and Eugene Y. Kissin¹³, ¹Rheumatology, Mayo Clinic, Scottsdale, AZ, ²Section of Rheumatology, University of Nebraska Medical Center, Omaha, NE, ³Rheumatology, Santa Clara Valley Medical Center, San Jose, CA, ⁴Evergreen Medical Group, Santa Clara Valley Medical Center, San Jose, CA, ⁵University of Wisconsin Hospital and Clinics, Madison, WI, ⁶Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, ⁷Rheumatology, Intermountain Healthcare, Salt Lake City, UT, ⁸Intermountain Healthcare, Salt Lake City, UT, ⁹Stanford University, Palo Alto, CA, ¹⁰Division of Rheumatology, Department of Internal Medicine, Loma Linda University, Loma Linda, CA, ¹¹Arthritis, Rheumatic and Back Disease Associates, Moorestown, NJ, ¹²Arthritis & Rheumatism Associates PC, Wheaton, MD, ¹³Rheumatology, Boston University, Boston, MA
Background/Purpose: Rheumatologists commonly use synovial fluid analysis to help establish a diagnosis in patients with joint effusions. Although tenosynovial (TS) effusions are common in rheumatic…
Abstract Number: 1205 • 2018 ACR/ARHP Annual Meeting
Musculoskeletal Ultrasound and Conventional Radiography Evaluation of the Hip in Patients with Calcium Pyrophosphate Deposition Disease
Andrea Di Matteo¹, Emilio Filippucci¹, Edoardo Cipolletta¹, Alice Musca², Marina Carotti³, Riccardo Mashadi Miza⁴, Diogo Jesus⁵, Marco Di Carlo¹, Fausto Salaffi¹ and Walter Grassi¹, ¹Polytechnic University of Marche, Rheumatology Clinic, Jesi, Italy, ²Internal Medicine and Rheumatology Department, Bucharest, Romania, ³Polytechnic University of Marche, Radiology Unit, Ancona, Italy, ⁴Dipartimento Diagnostica per Immagini, Ospedale di Cittadella, ULSS 6 Euganea, Cittadella (PD), Italy, ⁵Rheumatology Department, Centro Hospitalar e Universitario de Coimbra, Coimbra, Portugal
Background/Purpose: Conventional radiography (CR) and, more recently, US play a key role in the diagnosis of CPPD. To date, only a very few studies have…
Abstract Number: 1253 • 2018 ACR/ARHP Annual Meeting
Lipid Screening and Treatment Patterns Among Patients with Rheumatic Diseases
Alexander Peck¹, Gilbert Ortega², Jawad Bilal³, Ella Starobinska², Phan Saligrama² and Dominick Sudano⁴, ¹Division of Internal Medicine, University of Arizona College of Medicine, Tucson, AZ, ²Internal Medicine, University of Arizona, Tucson, Tucson, AZ, ³Internal Medicine, University of Arizona, Tucson, AZ, ⁴University of Arizona Arthritis Center, University of Arizona, Tucson, AZ
Background/Purpose: The importance of lipid management is well recognized in rheumatic diseases. In fact, annual cardiovascular risk assessment is especially recommended for individuals with rheumatoid…
Abstract Number: 1286 • 2018 ACR/ARHP Annual Meeting
Pretreatment and Coadministration with Methotrexate Improved Durability of Pegloticase (Krystexxa) Response: A Prospective, Proof-of-Concept, Case Series
John Botson¹ and Jeff Peterson², ¹Orthopedic Physicians Alaska, Anchorage, AK, ²Western Washington Arthritis Clinic, Bothell, WA
Background/Purpose: Pegloticase is a recombinant DNA-produced porcine-like uricase enzyme which metabolizes relatively insoluble urate to highly soluble allantoin. It is used in the treatment of…
Abstract Number: 1292 • 2018 ACR/ARHP Annual Meeting
HLA-B*58:01 Genotype and the Risk of Allopurinol-Associated Severe Cutaneous Adverse Reactions in a Predominately Black or African American Population with Advanced Chronic Kidney Disease
Sarah Ford¹, Pamela Kimball¹, Gaurav Gupta¹ and Nehal Shah², ¹Virginia Commonwealth University, Richmond, VA, ²Medicine/Rheumatology, Virginia Commonwealth University, Richmond, VA
Background/Purpose: Allopurinol is the first line urate lowering drug used for treatment of gout. Its most feared side effect includes development of hypersensitivity drug reactions…
Abstract Number: 1296 • 2018 ACR/ARHP Annual Meeting
A Novel Potent and Selective Urate Transporter 1 Inhibitor, NC-2700, with pH-Raising Effect on Low Urinary pH
Masuharu Hirano¹, Takafumi Muto¹, Toshitake Hirai², Promsuk Jutabha³, Naohiko Anzai⁴, Toru Horie⁵, Hitoshi Endou⁶ and Tomio Yamakawa⁷, ¹Discovery Research Laboratories, Nippon Chemiphar Co., Ltd., Misato, Saitama Prefecture, Japan, ²Nippon Chemiphar Co., Ltd., Misato, Saitama Prefecture, Japan, ³Dokkyo Medical University School of Medicine, Tochigi, Japan, ⁴Chiba University Graduate School of Medicine, Chiba, Japan, ⁵Dethree Res Lab Inc., Tsukuba, Japan, ⁶J-Pharma Co., Ltd., Yokohama, Japan, ⁷Discovery Research Laboratories, Nippon Chemiphar Co., Ltd., Misato, Saitama prefecture, Japan
Background/Purpose: In most patients with gout, renal underexcretion of uric acid is the main mechanism for hyperuricemia. However, for the risk of uric acid kidney…
Abstract Number: 1299 • 2018 ACR/ARHP Annual Meeting
A Novel Recombinant Oral Urate Oxidase (UrOx) Alln-346 Reduces Severe Hyperuricemia and Normalizes Hyperuricosuria in Nephropathic Urox Knockout (UrOxKO) Mice
Danica Grujic¹, Aditi Desphande¹, Robert Terkeltaub², Nadia Mosiichuk³, Kateryna Goncharva⁴ and Stefan Pirzynowski⁴, ¹R&D, Allena Pharmaceuticals, Newton, MA, ²VA San Diego Healthcare System, San Diego, CA, ³SGPlus and Lund University, Lund, Sweden, ⁴Lund University and SGPlus, Lund, Sweden
A novel recombinant oral urate oxidase (UrOx) ALLN-346 reduces severe hyperuricemia and normalizes hyperuricosuria in nephropathic UrOx knockout (UrOxKO) miceBackground/Purpose: Limitations in efficacy and/or tolerance…

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