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Abstract Number: 160 • 2013 ACR/ARHP Annual Meeting
Association Analysis Of The Organic Anion Transporter 4 and Urate Transporter 1 Locus With Gout In New Zealand Case-Control Sample Sets Reveals Multiple Ancestral-Specific Effects
Tony R. Merriman¹, Amanda Phipps-Green¹, Jade E. Hollis-Moffatt², Marilyn E. Merriman¹, Ruth Topless¹, Grant Montgomery³, Brett Chapman³, Lisa K. Stamp⁴, Nicola Dalbeth⁵ and Tanya Flynn², ¹Department of Biochemistry, University of Otago, Dunedin, New Zealand, ²University of Otago, Dunedin, New Zealand, ³Queensland Institute of Medical Research, Brisbane, Australia, ⁴University of Otago, Christchurch, New Zealand, ⁵Medicine, University of Auckland, Auckland, New Zealand
Background/Purpose: There are genetic variants in urate transporters SLC22A11 (OAT4) and SLC22A12 (URAT1) that influence serum urate levels in European Caucasian. However, there is no…
Abstract Number: 170 • 2013 ACR/ARHP Annual Meeting
Association Of BMI, 8 SNPs Reported To Be Related To Gout Phenotype and Their Interaction In Gout Incidence In Framingham Heart Study
Jasvinder A. Singh^1,2, Ana Vazquez³, Richard Reynolds³, Vinodh Srinivasasainagendra⁴, S. Louis Bridges Jr.⁵ and David Allison³, ¹Rheumatology, Birmingham VA, Birmingham, AL, ²Department of Medicine, University of Alabama, Tuscaloosa, AL, ³University of Alabama at Birmingham, Birmingham, AL, ⁴University of alabama at birmingham, birmingham, AL, ⁵Division of Clinical Immunology & Rheumatology, University of Alabama at Birmingham, Birmingham, AL
Background/Purpose: We aim to assess the association of 8 serum urate SNPs and BMI and their interactions with incident gout in a population-based cohort study. Methods:…
Abstract Number: 2743 • 2013 ACR/ARHP Annual Meeting
Targeted Activation Of The Metabolic Super-Regulator AMP-Activated Protein Kinase (AMPK) Blunts Gouty Inflammation
Ru L. Bryan¹, Robert Terkeltaub² and Yun Wang³, ¹Medicine-Rheumatology, VA Medical Center/University of California San Diego, San Diego, CA, ²Medicine-Rheumatology, VA Medical Ctr/University of California San Diego, San Diego, CA, ³Medicine-Rheumatology, VA Medical Ctr/UCSD, San Diego, CA
Background/Purpose: Gout is associated with both multiple dietary triggers and metabolic co-morbidities, including obesity, metabolic syndrome, and diabates. AMP-activated protein kinase (AMPK) is a master…
Abstract Number: 2661 • 2013 ACR/ARHP Annual Meeting
Physical Activity, Adiposity, and The Risk Of Gout In Women: The Nurses Health Study
Hyon Choi^1,2,3, Lindsay C Burns^4,5, Yuqing Zhang⁶, Sharan Rai¹ and Gary Curhan⁷, ¹Arthritis Research Centre of Canada, Richmond, BC, Canada, ²Section of Rheumatology and the Clinical Epidemiology Unit, Boston University School of Medicine, Boston, MA, ³Division of Rheumatology, Allergy, and Immunology Massachusetts General Hospital, Harvard Medical School, Boston, MA, ⁴Research, Arthritis Research Centre of Canada, Richmond, BC, Canada, ⁵Department of Dermatology and Skin Science, University of British Columbia, Vancouver, BC, Canada, ⁶Clinical Epidemiology Unit, Boston University School of Medicine, Boston, MA, ⁷German Research Center for Environmental Health, Harvard Medical School, Boston, MA
Background/Purpose: There is a remarkable, increasing disease burden of gout and its associated cardiovascular (CV)-metabolic comorbidities in the US. While the benefits of physical exercise…
Abstract Number: 2666 • 2013 ACR/ARHP Annual Meeting
Implementing a Personalized Health Plan To Improve Therapeutic Outcomes In Veterans With Gout
Astrud Lorraine Leyva¹, Una E. Makris² and Salahuddin Kazi³, ¹Division of Rheumatic Diseases, UT Southwestern Medical Center, Dallas, TX, ²Rheumatology, UT Southwestern Medical Center, VA Medical Center, Dallas, TX, ³Internal Medicine/Rheumatology, UT Southwestern Medical Center, Dallas, TX
Background: Gout is a chronic crystal-induced arthritis that predominantly occurs among men with rising prevalence with advancing age. Patients with uncontrolled gout present with recurrent…
Abstract Number: 2190 • 2013 ACR/ARHP Annual Meeting
Clinical and Immunologic Description Of Pediatric Conditions With Interferon-Regulated Gene Signatures (Chronic Atypical Neutrophilic Dermatosis Lipodystrophy Elevated Tempature, Aicardi Goutieres Syndrome, Juvenile Dermatomyositis, Juvenile Systemic Lupus Erythematosus)
Hanna Kim¹, Adriana Almeida de Jesus², Yin Liu³, Yan Huang¹, Gina Montealegre⁴, Dawn Chapelle⁵, Nicole Plass¹, Wanxia Tsai⁶, Massimo Gadina⁷, Lisa G. Rider⁸, Adeline Vanderver⁹ and Raphaela Goldbach-Mansky¹, ¹Translational Autoinflammatory Diseases Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, MD, ²Translational Autoinflammatory Disease Section, NIAMS/NIH, Bethesda, MD, ³Translational Autoinflammatory Disease Section, Office of the Clinical Director, NIAMS/NIH, Bethesda, MD, ⁴Office of the Clinical DIrector, NIAMS / NIH, Bethesda, MD, ⁵Office of the Clinical Director, NIAMS / NIH, Bethesda, MD, ⁶Translational Immunology Section, NIAMS / NIH, Bethesda, MD, ⁷Translational Immunology Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, MD, ⁸Environmental Autoimmunity Group, NIEHS, NIH, Bethesda, MD, ⁹Pediatric Neurology, Children's National Medical Center, Washington, DC
Background/Purpose: Increased interferon (IFN) regulated gene (IRG) expression has been reported in juvenile systemic lupus (JSLE)1 and juvenile dermatomyositis (JDM)2. Recently, two monogenic conditions chronic…
Abstract Number: 2090 • 2013 ACR/ARHP Annual Meeting
The Effects of Commercially Available Footwear On Foot Pain and Disability in People With Gout: A Feasibility Study
Keith Rome¹, Sarah Stewart², Alain Vandal^3,4, Peter J. Gow⁵, Peter J. McNair² and Nicola Dalbeth⁶, ¹Health & Rehabilitation Research Institute, Auckland, New Zealand, AUT University, Auckland, New Zealand, ²Health & Rehabilitation Research Institute, AUT University, Auckland, New Zealand, ³Faculty of Health and Environmental Sciences, AUT University, Auckland, New Zealand, ⁴Counties Manukau District Health Board, Auckland, New Zealand, ⁵Rheumatology Dept, Middlemore Hospital, Auckland, New Zealand, ⁶Medicine, University of Auckland, Auckland, New Zealand
Background/Purpose: The non-pharmacological management goals for people with foot-related rheumatic diseases are pain management, preservation of foot function and patient mobility. One of the therapeutic…
Abstract Number: 2009 • 2013 ACR/ARHP Annual Meeting
Outcome Of Allopurinol Or Febuxostat Treatment In Gout Patients Naïve To Urate-Lowering Therapy
Puja Khanna¹, Hind Hatoum^2,3, Swu-Jane Lin^2,4, Aki Shiozawa⁵, Kasem Akhras⁶ and Dinesh Khanna¹, ¹Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, ²Hind T. Hatoum and Company, Chicago, IL, ³University of Illinois at Chicago, chicago, IL, ⁴University of Illinois at Chicago, Chicago, IL, ⁵Global Outcomes and Epidemiology Research, Takeda Pharmaceuticals International, Inc, Deerfield, IL, ⁶Global Outcomes Research, Formerly of Takeda Pharmaceuticals International, Inc, Deerfield, IL
Background/Purpose: In the US, 3.9% (8.3 million) of the population have self-reported gout, and 21.4% (43.3 million) have hyperuricemia. The 2012 ACR guidelines recommend febuxostat…
Abstract Number: 1991 • 2013 ACR/ARHP Annual Meeting
Gout In Ambulatory Care Settings In The US: 1993-2009
Eswar Krishnan and Linjun Chen, Medicine, Stanford University, Palo Alto, CA
Background/Purpose: Gouty arthritis (gout) is primarily cared for in ambulatory care settings. Yet, there are few nationally representative data on ambulatory health care utilization of…
Abstract Number: 1992 • 2013 ACR/ARHP Annual Meeting
Trends In Outpatient Treatment Of Gout In The US: From 1993 To 2009
Eswar Krishnan and Linjun Chen, Medicine, Stanford University, Palo Alto, CA
Background/Purpose: Gouty arthritis (gout) is primarily managed in the community by primary care providers. Relatively little is known about the treatment patterns as well as…
Abstract Number: 2000 • 2013 ACR/ARHP Annual Meeting
Changes In The Prevalence Of Gout In The United States General Population Between 1960 and 2010: The National Health and Nutrition Examination Surveys
Eswar Krishnan and Linjun Chen, Medicine, Stanford University, Palo Alto, CA
Background/Purpose: Despite the widely shared impression that the prevalence of gouty arthritis (gout) has increased over time in the US few population data are available.…
Abstract Number: 1989 • 2013 ACR/ARHP Annual Meeting
Determinants Of Functional Disability In Patients With Gout: Longitudinal Analysis From a Multicentre Observational Study Of The Italian Society For Rheumatology
Carlo Alberto Scirè¹, Maria Manara¹, Greta Carrara¹, Marco A. Cimmino², Marcello Govoni³, Fausto Salaffi⁴, Leonardo Punzi⁵, Carlomaurizio Montecucco⁶, Marco Matucci-Cerinic⁷ and Giovanni Minisola⁸, ¹Epidemiology Unit -Italian Society for Rheumatology, Milano, Italy, ²Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, Genoa, Italy, ³Clinical and Experimental Medicine, Section of Rheumatology, University of Ferrara, Ferrara, Italy, ⁴Rheumatology Unit - Polytechnic University of the Marche, Jesi, Italy, ⁵Department of Medicine - DIMED, University of Padova, Padova, Italy, ⁶Rheumatology, University and IRCCS Policlinico S. Matteo Foundation, Pavia, Italy, ⁷Rheumatology, University of Florence, Azienda Ospedaliera Careggi, Florence, Italy, ⁸Rheumatology Unit, San Camillo-Forlanini Hospital, Rome, Italy
Background/Purpose: Gout is the most prevalent arthritis and significantly impacts on function. Beside the influence of concurrent comorbidities, identifying disease-related prognostic factors may help to…
Abstract Number: 1990 • 2013 ACR/ARHP Annual Meeting
Treatment Of ACUTE Gout In The Emergency Department Evaluated According To The 2012 American College Of Rheumatology Guidelines
Naomi Schlesinger¹, Tina Chang Young², Diane C. Radvanski³, Dirk Moore⁴ and Robert Eisenstein⁵, ¹Medicine, UMDNJ-Robert Wood Johnson Medical School, New Brunswick, NJ, ²Department of Biostatistics, UMDNJ/School of Public Health, Piscataway, NJ, ³Department of Medicine, Division of Rheumatology, Robert Wood Johnson Medical School, New Brunswick, NJ, ⁴Department of Biostatistics, UMDNJ - School of Public Health, Piscataway, NJ, ⁵, Department of Emergency Medicine, UMDNJ- Robert Wood Johnson Medical School, New Brunswick, NJ
Background/Purpose: Acute gout attacks account for a substantial number of emergency department (ED) visits. Our aim was to record acute gout treatment in the ED…
Abstract Number: 1993 • 2013 ACR/ARHP Annual Meeting
Geographic Variations Of Gout Epidemiology In The United Kingdom: A Nationwide Population Study
Chang-Fu Kuo^1,2, Michael Doherty³, Matthew J. Grainge⁴ and Weiya Zhang¹, ¹Academic Rheumatology, School of Clinical Sciences, University of Nottingham, Nottingham, United Kingdom, ²Division of Rheumatology, Allergy and Immunology, Chang Gung Memorial Hospital, Taipei, Taiwan, ³Academic Rheumatology, University of Nottingham, Nottingham, United Kingdom, ⁴Division of Epidemiology and Public Health, School of Community Health Sciences,, University of Nottingham, Nottingham, United Kingdom
Background/Purpose: To examine geographic variations of gout prevalence, incidence and management in the United Kingdom. Methods: We used the Clinical Practice Research Data-link (CPRD) to…
Abstract Number: 1994 • 2013 ACR/ARHP Annual Meeting
Performance Of Gout Impact Scale Of The Gout Assessment Questionnaire In a Longitudinal Observational Study Of Patients With Gout
Puja Khanna¹, Cleopatra Aquino-Beaton², Jasvinder A. Singh³, Erin Duffy⁴, David Elashoff⁵ and Dinesh Khanna⁶, ¹Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, ²Rheumatology, VA Greater Los Angeles Healthcare System, Los Angeles, CA, ³Department of Medicine, University of Alabama, Tuscaloosa, AL, ⁴Medicine, University of California Los Angeles, Los Angeles, CA, ⁵Medicine- Statistic Core, UCLA Department of Medicine Statistics Core, Los Angeles, CA, ⁶University of Michigan Health System, Ann Arbor, MI
Background/Purpose: Gout Assessment Questionnaire (GAQ2.0) is a validated disease-specific measure used to evaluate patient reported outcomes in gout studies. The objective was to evaluate the…

Association Analysis Of The Organic Anion Transporter 4 and Urate Transporter 1 Locus With Gout In New Zealand Case-Control Sample Sets Reveals Multiple Ancestral-Specific Effects

Association Of BMI, 8 SNPs Reported To Be Related To Gout Phenotype and Their Interaction In Gout Incidence In Framingham Heart Study

Targeted Activation Of The Metabolic Super-Regulator AMP-Activated Protein Kinase (AMPK) Blunts Gouty Inflammation

Physical Activity, Adiposity, and The Risk Of Gout In Women: The Nurses Health Study

Implementing a Personalized Health Plan To Improve Therapeutic Outcomes In Veterans With Gout

Clinical and Immunologic Description Of Pediatric Conditions With Interferon-Regulated Gene Signatures (Chronic Atypical Neutrophilic Dermatosis Lipodystrophy Elevated Tempature, Aicardi Goutieres Syndrome, Juvenile Dermatomyositis, Juvenile Systemic Lupus Erythematosus)

The Effects of Commercially Available Footwear On Foot Pain and Disability in People With Gout: A Feasibility Study

Outcome Of Allopurinol Or Febuxostat Treatment In Gout Patients Naïve To Urate-Lowering Therapy

Gout In Ambulatory Care Settings In The US: 1993-2009

Trends In Outpatient Treatment Of Gout In The US: From 1993 To 2009

Changes In The Prevalence Of Gout In The United States General Population Between 1960 and 2010: The National Health and Nutrition Examination Surveys

Determinants Of Functional Disability In Patients With Gout: Longitudinal Analysis From a Multicentre Observational Study Of The Italian Society For Rheumatology

Treatment Of ACUTE Gout In The Emergency Department Evaluated According To The 2012 American College Of Rheumatology Guidelines

Geographic Variations Of Gout Epidemiology In The United Kingdom: A Nationwide Population Study

Performance Of Gout Impact Scale Of The Gout Assessment Questionnaire In a Longitudinal Observational Study Of Patients With Gout

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