Abstract Number: 2254 • 2018 ACR/ARHP Annual Meeting
Update of SEL-212 Phase 2 Clinical Data in Symptomatic Gout Patients: Svp-Rapamycin Combined with Pegadricase Mitigates Immunogenicity and Enables Sustained Reduction of Serum Uric Acid Levels, Low Rate of Gout Flares and Monthly Dosing
Background/Purpose: Pegylated uricases are promising therapies for the treatment of severe chronic gout, but are limited by their immunogenicity. We have previously shown that synthetic…Abstract Number: 2255 • 2018 ACR/ARHP Annual Meeting
Increased Cost Burden in an Early Diagnosed Cohort of Uncontrolled Versus Controlled Gout: Analysis of a Large US Payer Database
Background/Purpose: Gout is a progressive systemic inflammatory disease that is widely prevalent, estimated to effect 3.9% or 8.3 million people of the United State (US)…Abstract Number: 2352 • 2018 ACR/ARHP Annual Meeting
Predictors of Patient and Physician Perceptions of Gout Disease Activity
Background/Purpose: It is unknown what factors contribute to patient and physician perceptions of gout disease activity, and how these perceptions align. The aim of this…Abstract Number: 2362 • 2018 ACR/ARHP Annual Meeting
Understanding Patients’ Perceptions of Gout
Background/Purpose: Past research has shown that patients’ (pts’) knowledge of their disease influences health-related behavior. The objective of this study is to explore gout pts’…Abstract Number: 2962 • 2018 ACR/ARHP Annual Meeting
Diagnostic Accuracy of Gout in Electronic Health Records and the Role of Rheumatology Electronic Consults
Background/Purpose: Gout is the most prevalent inflammatory arthritis globally. Despite treatment advances, it still has a significant effect on quality of life and healthcare costs.…Abstract Number: 2964 • 2018 ACR/ARHP Annual Meeting
Detection of Uric Acid Crystals in the Vasculature of Patients with Gout Using Dual-Energy Computed Tomography
Background/Purpose: Many recent studies have shown an association between gout and increased cardiovascular risk, however the mechanism by which this occurs is unclear. Dual-Energy Computed…Abstract Number: 2965 • 2018 ACR/ARHP Annual Meeting
Targeting Glucose Metabolism in the Murine Air Pouch Model of Acute Gouty Inflammation
Background/Purpose: Emerging evidence indicates that macrophage activation is critically supported by glucose metabolic shifts. Although macrophages are key contributors to inflammation, little is known about…Abstract Number: 2966 • 2018 ACR/ARHP Annual Meeting
Ultrasound Shows Rapid Reduction of Uric Load during Treat-to-Target Approach in Gout Patients: Results from a Longitudinal Study
Background/Purpose: Uric monosodium urate (MSU) depositions are detected by ultrasound (US), and US is included in the ACR/EULAR classification criteria for gout. OMERACT definitions for…Abstract Number: 2968 • 2018 ACR/ARHP Annual Meeting
Role of Choline in Gouty Inflammation
Background/Purpose: Gout is characterized by deposition of monosodium urate (MSU) crystals in articular joints, where they activate macrophages inducing NLRP3 inflammasome activation and bioactive IL-1β…Abstract Number: 2969 • 2018 ACR/ARHP Annual Meeting
Allopurinol Dose Escalation Slows Progression of CT Bone Erosion in People with Gout: Imaging Sub-Study of a Randomized Control Trial
Background/Purpose: Bone erosion is a frequent complication of severe gout. Computed tomography (CT) is considered the gold standard for measurement of bone erosion. CT studies…Abstract Number: 60 • 2017 ACR/ARHP Annual Meeting
Low and Moderate Intensity Exercise Suppresses Inflammatory Responses in an Acute Mouse Model of Gout and Suggests Therapeutic Efficacy
Background/Purpose: Little is known regarding the potential benefits of exercise on managing acute gout. Consequently, recent clinical practice guidelines released by the American College of…Abstract Number: 99 • 2017 ACR/ARHP Annual Meeting
A Pilot Study of the Use of a Validated Gout Script Concordance Test Assessment in an Interdisciplinary Musculoskeletal Education Program
Background/Purpose: A validated script concordance assessment (SCT) for gout was created for use in the internal medicine residency program at the University of Maryland Medical…Abstract Number: 117 • 2017 ACR/ARHP Annual Meeting
Using Goutpro to Make Medical Trainees Gout Pros- a Single Blinded Randomized Control Study
Background/Purpose: Gout is the most common type of inflammatory arthritis in the U.S., affecting 4% of the population. Despite modern advancements and the availability of…Abstract Number: 170 • 2017 ACR/ARHP Annual Meeting
Genome-Wide Association Study of Clinically-Ascertained Gout and Subtypes Identifies Multiple Susceptibility Loci Including Transporter Genes
Background/Purpose: We performed a genome-wide association study (GWAS) of gout and its subtypes to identify novel gout loci including those that are subtype-specific. Methods: Putative…Abstract Number: 187 • 2017 ACR/ARHP Annual Meeting
Improved Identification of Pseudogout in Electronic Medical Records By Adding Text String Searching to a Billing Code Algorithm
Background/Purpose: Calcium pyrophosphate deposition disease (CPPD) has a spectrum of manifestations, of which pseudogout is the most acute inflammatory phenotype. To facilitate clinical research on…
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