Session Title: Patient Outcomes, Preferences, and Attitudes Poster III
Session Type: ACR Poster Session C
Session Time: 9:00AM-11:00AM
Background/Purpose: To describe the work productivity and activity impairment in adult patients diagnosed with primary Sjögren´s Syndrome (pSS). To evaluate the association between activity impairment and clinical manifestations, depression and anxiety. To compare the activity impairment according to educational level and site of care (public or private centers) as surrogates of socio-economic status.
Methods: We included patients with diagnosis of pSS according to the American-European criteria (2002) treated in 11 private and public argentine rheumatologic centers between November 2013 and December 2016. All patients with another autoimmune rheumatic or chronic disease were excluded. The WPAI questionnaire was used. Design: observational, analytic, cross-sectional study. For the descriptive analysis, continuous variables were informed as mean and SD. Categorical variables were reported in percentage. A multiple linear regression model was performed, taking impaired activity due to health as the dependent variable, adjusted by potential confounders. The performance of the model was evaluated (assumptions, atypical observations, multicollinearity). If linearity and/or homoscedasticity was not fulfilled, transformation of variables or robust regression was performed, as appropriate.
Results: 252 patients were included, 98.38% were female, mean age of 52.64 years (+/-14.84). The mean percentage of working time lost due to health was 15.74% (+/-30.12.CI95%:9.58- 21.90); disability work due to health was 27.18% (+/-30.19. CI95%:21.25-33.11), the total disability percentage due to health was 33.70% (+/-35.76.CI95%: 26.39-41.01) and impaired activity due to health was 34.17% (+/-30.94.CI95%:30.35-37.99). The following variables showed significantly and independent association in the multivariable analysis of robust regression: xerostomy (β coefficient: 0.25. CI 95%: 0.13-0.37), arthritis (β coefficient: 11.15.CI 95%:0.55-21.74), mild depression (β coefficient: 8.77. CI 95%: 1.43-16.12), moderate depression (β coefficient: 25.47. CI 95%: 13.84-37.10), moderately severe depression (β coefficient: 36.92. CI 95%: 26.91-46.93), severe depression (β coefficient: 32.12. CI 95%: 16.31- 48.10). The mean impaired activity due to health was 38.24% (+/- 30.67) in patients treated in public centers vs 28.04% (+/-30.61) on private centers, being this difference statistically significant. No statistically significant differences were found between patients with full or higher secondary education ((32.96% (+/- 31.03)) vs patients with lower educational level ((35.73% (+/-31.08)).
Conclusion: We found a decrease in the score of all WPAI scales. Arthritis, xerostomy and depression were significantly and independently associated with impaired activity due to health. The patients treated in public centers presented a greater impaired activity. This could be an expression of the impact of the socio-economic status in these aspects.
To cite this abstract in AMA style:Bejarano M, Secco A, Catalan Pellet A, Mamani M, Papasidero S, Demarchi J, Asnal C, Crow C, Nitsche A, Encinas L, Caeiro F, Gobbi C, Albiero E, Gomez A, Barreira JC, Aguila Maldonado R, Garcia M, Gallardo M, Soriano ER, Raiti L, Salvatierra G, Eimon A. Work Productivity and Activity Impairment in Primary Sjögren’s Syndrome [abstract]. Arthritis Rheumatol. 2017; 69 (suppl 10). https://acrabstracts.org/abstract/work-productivity-and-activity-impairment-in-primary-sjogrens-syndrome/. Accessed November 20, 2018.
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