Session Information
Session Type: Abstract Submissions (ACR)
Background/Purpose: : In the general population, vitamin D deficiency is associated with cardiovascular disease including myocardial infarction and stroke. In SLE, Vitamin D deficiency has been associated with carotid plaque. We investigated whether low vitamin D would predict change in subclinical measures of atherosclerosis over 2 years.
Methods: 167 SLE patients (93% female, 63% Caucasian, 32% African-American, mean age 45 yrs) had measurement of coronary artery calcium and carotid intima-media thickness IMT (IMT)) and vitamin D.
Results:
Table 1 shows the baseline characteristics by vitamin D status.
|
Variable |
Number (%) with the characteristic Vitamin D <32 (n=133) Vitamin D ≥32 (n=34) |
p-value |
|
|
Age |
|
|
|
|
18-30 |
14 (11%) |
4 (12%) |
0.80 |
|
31-49 |
75 (56%) |
17 (50%) |
|
|
50+ |
44 (33%) |
13 (38%) |
|
|
Ethnicity |
|
|
|
|
Caucasian |
79 (59%) |
27 (79%) |
0.066 |
|
African-American |
47 (35%) |
5 (15%) |
|
|
Other |
7 (5%) |
2 (6%) |
|
|
Gender |
|
|
|
|
Female |
124 (93%) |
31 (91%) |
0.68 |
|
Male |
9 (7%) |
3 (9%) |
|
Table 2. Changes in coronary artery calcium (CAC) and carotid intima-media thickness (IMT)
|
Measure |
Mean at baseline |
Mean after 2 years |
Mean Change |
p-value for change |
Difference in change (95% CI)* |
p-value for difference between groups** |
|
Loge(CAC score+1) |
|
|
|
|
|
|
|
Vitamin D <32 |
1.18 |
1.23 |
0.05 |
0.63 |
-0.14 (-0.58, 0.30) |
0.69 |
|
Vitamin D ≥32 |
1.11 |
1.30 |
0.19 |
0.25 |
|
|
|
Carotid IMT |
|
|
|
|
|
|
|
Vitamin D <32 |
0.58 |
0.66 |
0.08 |
<0.0001 |
0.01 (-0.02, 0.04) |
0.59 |
|
Vitamin D ≥32 |
0.58 |
0.65 |
0.07 |
<0.0001 |
|
|
This table is based on the 123 patients with vitamin D <32 and the 32 patients with vitamin D ≥32 for whom there were both baseline and follow-up measures.
* Difference in change: measure in vitamin D <32 group minus measure in vitamin D ≥32 group.
** Adjusted for ethnicity.
Conclusion: Vitamin D deficiency was not associated with any measure of subclinical atherosclerosis in SLE. Another study by Bruce et al (Rheumatology:2012) did not show an association of low Vitamin D in SLE with carotid IMT or plaque either. Vitamin D deficiency did not predict progression of subclinical atherosclerosis over 2 years. Future studies with larger sample size and longer follow up are needed to confirm our findings.
Disclosure:
A. Kiani,
None;
H. Fang,
None;
E. Akhter,
None;
L. S. Magder,
None;
M. Petri,
None.
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ACR Meeting Abstracts - https://acrabstracts.org/abstract/vitamin-d-deficiency-is-not-associated-with-nor-does-it-predict-progression-of-coronary-artery-calcium-or-carotid-intima-media-thickness-in-systemic-lupus-erythematosus/