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Abstract Number: 1390

Vitamin D Deficiency Is Not Associated with Nor Does It Predict Progression of Coronary Artery Calcium or Carotid Intima-Media Thickness in Systemic Lupus Erythematosus

Adnan Kiani1, Hong Fang1, Ehtisham Akhter2, Laurence S. Magder3 and Michelle Petri1, 1Johns Hopkins University School of Medicine, Baltimore, MD, 2Div of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, 3Department of Epidemiology and Public Health, University of Maryland, Baltimore, MD

Meeting: 2012 ACR/ARHP Annual Meeting

Keywords: coronary artery disease and systemic lupus erythematosus (SLE)

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Session Information

Title: Systemic Lupus Erythematosus: Clinical Aspects

Session Type: Abstract Submissions (ACR)

Background/Purpose: :  In the general population, vitamin D deficiency is associated with cardiovascular disease including myocardial infarction and stroke.  In SLE, Vitamin D deficiency has been associated with carotid plaque.  We investigated whether low vitamin D would predict change in subclinical measures of atherosclerosis over 2 years.

Methods: 167 SLE patients (93% female, 63% Caucasian, 32% African-American, mean age 45 yrs) had measurement of coronary artery calcium and carotid intima-media thickness IMT (IMT)) and vitamin D.

Results:

Table 1 shows the baseline characteristics by vitamin D status.

Variable

Number (%) with the characteristic

Vitamin D <32 (n=133)               Vitamin D ≥32 (n=34)

p-value

Age 

 

 

 

  18-30

14 (11%)

4 (12%)

0.80

  31-49

75 (56%)

17 (50%)

 

  50+

44 (33%)

13 (38%)

 

Ethnicity

 

 

 

  Caucasian

79 (59%)

27 (79%)

0.066

  African-American

47 (35%)

5 (15%)

 

  Other

7 (5%)

2 (6%)

 

Gender

 

 

 

  Female

124 (93%)

31 (91%)

0.68

  Male

9 (7%)

3 (9%)

 

Table 2.  Changes in coronary artery calcium (CAC) and carotid intima-media thickness (IMT)

Measure

Mean at baseline

Mean after 2 years

Mean Change

p-value for change

Difference in change (95% CI)*

p-value for difference between groups**

Loge(CAC score+1)

 

 

 

 

 

 

    Vitamin D <32

1.18

1.23

0.05

0.63

-0.14 (-0.58, 0.30)

0.69

    Vitamin D ≥32

1.11

1.30

0.19

0.25

 

 

Carotid IMT

 

 

 

 

 

 

    Vitamin D <32

0.58

0.66

0.08

<0.0001

0.01 (-0.02, 0.04)

0.59

    Vitamin D ≥32

0.58

0.65

0.07

<0.0001

 

 

This table is based on the 123 patients with vitamin D <32 and the 32 patients with vitamin D ≥32 for whom there were both baseline and follow-up measures.

* Difference in change: measure in vitamin D <32 group minus measure in vitamin D ≥32 group.

** Adjusted for ethnicity.

Conclusion: Vitamin D deficiency was not associated with any measure of subclinical atherosclerosis in SLE.  Another study by Bruce et al (Rheumatology:2012) did not show an association of low Vitamin D in SLE with carotid IMT or plaque either.  Vitamin D deficiency did not predict progression of subclinical atherosclerosis over 2 years.  Future studies with larger sample size and longer follow up are needed to confirm our findings.


Disclosure:

A. Kiani,
None;

H. Fang,
None;

E. Akhter,
None;

L. S. Magder,
None;

M. Petri,
None.

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ACR Meeting Abstracts - https://acrabstracts.org/abstract/vitamin-d-deficiency-is-not-associated-with-nor-does-it-predict-progression-of-coronary-artery-calcium-or-carotid-intima-media-thickness-in-systemic-lupus-erythematosus/

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