Date: Sunday, November 8, 2015
Session Type: ACR Poster Session A
Session Time: 9:00AM-11:00AM
To study the association between 25-hydroxyvitamin D (25(OH)D) levels and the clinical characteristics of patients with chronic inflammatory rheumatic diseases (CIRD).
Cross section from the baseline visit of the CARMA project (CARdiovascular in rheuMAtology), a 10-year prospective study evaluating the risk of cardiovascular events in rheumatoid arthritis (RA), ankylosing spondylitis (AS) and psoriatic arthritis (PsA) patients, and non-CIRD patients who attended rheumatology outpatient clinics from 67 hospitals in Spain. Non-CIRD group was frequency matched by age with the joint distribution of the three CIRD groups included in the study. 25(OH)D deficiency was defined if 25(OH)D vitamin levels were < 20 ng/ml.
2.234 patients (775 RA, 738 AS and 721 PsA) and 677 non-CIRD subjects were assessed. The median [p25-p75] 25(OH)D levels were: 20.4 [14.4-29.2] ng/ml in RA, 20.9 [13.1-29.0] in AS, 20.0 [14.0-28.8] in PsA, and 24.8 [18.4-32.6] ng/ml in non-CIRD patients. 25(OH)D deficiency was detected in 40.5% RA, 39.7% AS, 40.9% PsA and 26.7% non-CIRD controls (p<0.001). A statistically significant positive association between RA and 25(OH)D deficiency was found (adjusted (adj.) OR=1.46; 95% CI=1.09-1.96); p= 0.012. This positive association did not reach statistical significance for AS (adj. OR 1.23; 95%CI=0.85-1.80) and PsA (adj. OR 1.32; 95%CI=0.94-1.84). When the parameters of disease activity, severity or functional impairment were assessed, a marginally significant association between 25(OH)D deficiency and ACPA positive in RA patients (adj. OR=1.45; 95%CI=0.99-2.12; p=0.056), and between 25(OH)D deficiency and BASFI in AS patients (adj. OR=1.08; 95%CI=0.99-1.17); p=0.07) was also found.
Patients with CIRD, in particular those with RA, show an increased risk of having 25(OH)D deficiency compared to non-CIRD controls.
To cite this abstract in AMA style:Urruticoechea A, Martin MA, Castañeda S, Sánchez-Piedra CA, González-Juanatey C, Llorca J, Díaz-González F, Gonzalez-Gay MA. Vitamin D Deficiency in Rheumatoid Arthritis, Ankylosing Spondylitis and Psoriatic Arthritis. Results of the CARMA Study [abstract]. Arthritis Rheumatol. 2015; 67 (suppl 10). https://acrabstracts.org/abstract/vitamin-d-deficiency-in-rheumatoid-arthritis-ankylosing-spondylitis-and-psoriatic-arthritis-results-of-the-carma-study/. Accessed July 6, 2020.
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ACR Meeting Abstracts - https://acrabstracts.org/abstract/vitamin-d-deficiency-in-rheumatoid-arthritis-ankylosing-spondylitis-and-psoriatic-arthritis-results-of-the-carma-study/