Vitamin D Deficiency in Rheumatoid Arthritis, Ankylosing Spondylitis and Psoriatic Arthritis. Results of the CARMA Study

Ana Urruticoechea¹, Maria Auxiliadora Martin², Santos Castañeda³, Carlos Alberto Sánchez-Piedra², Carlos González-Juanatey⁴, Javier Llorca⁵, Federico Díaz-González⁶ and Miguel Angel Gonzalez-Gay⁷, ¹Hospital Can Misses, Ibiza, Spain, ²Research Unit of Spanish Society of Rheumatology,, Madrid, Spain, ³Rheumatology, H.U. La Princesa, Madrid, Spain, ⁴Division or Cardiology, Hospital Lusus Augusti, Lugo, Spain, ⁵Department of Epidemiology and Computational Biology, School of Medicine, University of Cantabria, and CIBER Epidemiología y Salud Pública (CIBERESP), IDIVAL, Santander, Spain, ⁶Investigation Unit, Sociedad Española de Reumatológía, Madrid, Spain, ⁷Rheumatology, Hospital Universitario Marqués de Valdecilla. IDIVAL, Santander, Spain

Meeting: 2015 ACR/ARHP Annual Meeting

Date of first publication: September 29, 2015

Keywords: Psoriatic arthritis, rheumatoid arthritis (RA) and spondylarthritis, Vitamin D

Session Information

Date: Sunday, November 8, 2015

Title: Spondylarthropathies and Psoriatic Arthritis - Clinical Aspects and Treatment Poster I: Clinical Aspects and Assessments

Session Type: ACR Poster Session A

Session Time: 9:00AM-11:00AM

Background/Purpose:

To study the association between 25-hydroxyvitamin D (25(OH)D) levels and the clinical characteristics of patients with chronic inflammatory rheumatic diseases (CIRD).

Methods:

Cross section from the baseline visit of the CARMA project (CARdiovascular in rheuMAtology), a 10-year prospective study evaluating the risk of cardiovascular events in rheumatoid arthritis (RA), ankylosing spondylitis (AS) and psoriatic arthritis (PsA) patients, and non-CIRD patients who attended rheumatology outpatient clinics from 67 hospitals in Spain. Non-CIRD group was frequency matched by age with the joint distribution of the three CIRD groups included in the study. 25(OH)D deficiency was defined if 25(OH)D vitamin levels were < 20 ng/ml.

Results:

2.234 patients (775 RA, 738 AS and 721 PsA) and 677 non-CIRD subjects were assessed. The median [p25-p75] 25(OH)D levels were: 20.4 [14.4-29.2] ng/ml in RA, 20.9 [13.1-29.0] in AS, 20.0 [14.0-28.8] in PsA, and 24.8 [18.4-32.6] ng/ml in non-CIRD patients. 25(OH)D deficiency was detected in 40.5% RA, 39.7% AS, 40.9% PsA and 26.7% non-CIRD controls (p<0.001). A statistically significant positive association between RA and 25(OH)D deficiency was found (adjusted (adj.) OR=1.46; 95% CI=1.09-1.96); p= 0.012. This positive association did not reach statistical significance for AS (adj. OR 1.23; 95%CI=0.85-1.80) and PsA (adj. OR 1.32; 95%CI=0.94-1.84). When the parameters of disease activity, severity or functional impairment were assessed, a marginally significant association between 25(OH)D deficiency and ACPA positive in RA patients (adj. OR=1.45; 95%CI=0.99-2.12; p=0.056), and between 25(OH)D deficiency and BASFI in AS patients (adj. OR=1.08; 95%CI=0.99-1.17); p=0.07) was also found.

Conclusion:

Patients with CIRD, in particular those with RA, show an increased risk of having 25(OH)D deficiency compared to non-CIRD controls.

Disclosure: A. Urruticoechea, None; M. A. Martin, None; S. Castañeda, None; C. A. Sánchez-Piedra, None; C. González-Juanatey, None; J. Llorca, None; F. Díaz-González, None; M. A. Gonzalez-Gay, None.

To cite this abstract in AMA style:

Urruticoechea A, Martin MA, Castañeda S, Sánchez-Piedra CA, González-Juanatey C, Llorca J, Díaz-González F, Gonzalez-Gay MA. Vitamin D Deficiency in Rheumatoid Arthritis, Ankylosing Spondylitis and Psoriatic Arthritis. Results of the CARMA Study [abstract]. Arthritis Rheumatol. 2015; 67 (suppl 10). https://acrabstracts.org/abstract/vitamin-d-deficiency-in-rheumatoid-arthritis-ankylosing-spondylitis-and-psoriatic-arthritis-results-of-the-carma-study/. Accessed .

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