ACR Meeting Abstracts

ACR Meeting Abstracts

Abstract Number: 1882

Vessels Under Fire: National Mortality Trends in Systemic Vasculitides in the United States, 1999–2020

Aziz-ur-Rahman Khalid1, Ghassan Makhoul2, Hasan Munshi2, Islam Rajab2, Emmanuel Olumuyide3, MD Walid Akram Hussain2, Ahmed Huzien2 and Robert Lahita4, 1St. Joseph's University Medical Center, wayne, 2St. Josephs University Medical Center, Paterson, 3Advocate Illinois Masonic Medical Center, Chicago, 4St. Josephs University Medical Center, Wayne, NJ

Meeting: ACR Convergence 2025

Keywords: , , ,

Session Information

Date: Tuesday, October 28, 2025

Title: (1877–1913) Epidemiology & Public Health Poster III

Session Type: Poster Session C

Session Time: 10:30AM-12:30PM

Background/Purpose: Systemic vasculitides are rare but potentially life-threatening inflammatory disorders affecting blood vessels. Despite therapeutic advances, national mortality trends across vasculitis subtypes remain poorly defined. We analyzed U.S. mortality trends from 1999–2020 using CDC WONDER, focusing on 10 vasculitis-related ICD-10 codes.

Methods: CDC WONDER Multiple Cause of Death data (1999–2020) were queried using ICD-10 codes: D69.0 (Allergic purpura), M30.0 (Polyarteritis nodosa), M30.1 (Churg-Strauss), M30.3 (Kawasaki disease), M31.3 (Wegener granulomatosis), M31.4 (Takayasu arteritis), M31.5 (Giant cell arteritis with polymyalgia rheumatica), M31.6 (Other giant cell arteritis), M31.7 (Microscopic polyangiitis), and M35.2 (Behçet disease). Age-adjusted mortality rates (AAMRs) were calculated using the 2000 U.S. standard population. Analyses were stratified by age, sex, race/ethnicity, urbanization, state, and place of death.

Results: A total of 11,602 vasculitis-related deaths occurred from 1999–2020. The overall AAMR was 0.15 per 100,000, declining from 0.20 in 1999 to 0.09 in 2020. The highest age-specific mortality occurred in adults ≥85 years (AAMR: 1.69), with the lowest in children 5–14 years (AAMR: 0.004). Females accounted for 56% of deaths, with AAMRs nearly equal between sexes (0.149 vs. 0.147). By race, American Indian/Alaska Native (0.165) and White (0.161) individuals had the highest AAMRs, while Black (0.068) and Asian/Pacific Islander (0.070) individuals had the lowest. Hispanic individuals had an AAMR of 0.117. The highest mortality occurred in micropolitan (0.205) and noncore rural areas (0.178). Regarding place of death, 54.3% occurred in inpatient medical facilities, followed by 20.0% at home and 13.3% in nursing homes.

Conclusion: Vasculitis-related mortality in the U.S. has declined substantially since 1999. However, disparities persist among older adults, rural populations, and American Indian/Alaska Native individuals. These findings highlight the need for improved access to rheumatologic care and early detection strategies in high-risk populations.

Supporting image 1Graphs showing state, urbanization, gender, race, age, and year mortality from Vasculitis

Disclosures: A. Khalid: None; G. Makhoul: None; H. Munshi: None; I. Rajab: None; E. Olumuyide: None; M. Hussain: None; A. Huzien: None; R. Lahita: None.

To cite this abstract in AMA style:

Khalid A, Makhoul G, Munshi H, Rajab I, Olumuyide E, Hussain M, Huzien A, Lahita R. Vessels Under Fire: National Mortality Trends in Systemic Vasculitides in the United States, 1999–2020 [abstract]. Arthritis Rheumatol. 2025; 77 (suppl 9). https://acrabstracts.org/abstract/vessels-under-fire-national-mortality-trends-in-systemic-vasculitides-in-the-united-states-1999-2020/. Accessed .

« Back to ACR Convergence 2025

ACR Meeting Abstracts - https://acrabstracts.org/abstract/vessels-under-fire-national-mortality-trends-in-systemic-vasculitides-in-the-united-states-1999-2020/