Validity of Simplified Ankylosing Spondylitis Disease Activity Scores (SASDAS) in Indian As Patients

Nagma Bansal¹, Lalit Duggal², Neeraj Jain², Amit Dua³ and Appu Patil¹, ¹Department of Rheumatology and Clinical Immunology, Sir Ganga Ram Hospital, DNB trainee, New Delhi, India, ²Department of Rheumatology and Clinical Immunology, Sir Ganga Ram Hospital, Consultant, New Delhi, India, ³Department of Rheumatology and Clinical Immunology, Sir Ganga Ram Hospital, Fellow, New Delhi, India

Meeting: 2015 ACR/ARHP Annual Meeting

Date of first publication: September 29, 2015

Keywords: Ankylosing spondylitis (AS)

Session Information

Date: Sunday, November 8, 2015

Title: Epidemiology and Public Health Poster I: Comorbidities and Outcomes of Systemic Inflammatory Diseases

Session Type: ACR Poster Session A

Session Time: 9:00AM-11:00AM

Background/Purpose:

Ankylosing Spondylitis Disease Activity Score (ASDAS) is a complex score for monitoring disease activity and ASDAS calculator is required for estimation. This study aimed to develop a simplified version which may be useful in AS patients in India.

Methods:

Consenting AS patients (modified New York and/or Assessment in Ankylosing Spondylitis 2009 criteria) were recruited between Jan 2012 and Dec 2014; n=254. Sociodemographic data and disease characteristics (Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), Bath Ankylosing Spondylitis Functional Index (BASFI), and Ankylosing Spondylitis Quality of Life (ASQoL), erythrocyte sedimentation rate (ESR) by Westergren’s method, and C-reactive protein (CRP)by nephelometry were collected. Simplified ASDAS (SASDAS) was calculated as the simple sum ofpatient global assessment (using visual analogue scale), back pain (BASDAI question no. 2), peripheral pain and swelling (BASDAI question no. 3), morning stiffness (BASDAI question no. 6), and either ESR in millimeters per hour (for SASDAS-ESR) or, CRP in mg/L (for SASDAS-CRP); this sum was divided by 10 to obtain the final score.

Results:

Most patients (224/254, 88.18 %) were males with median age of 30 years. Median disease duration was 4 years. SASDAS-ESR and SASDAS-CRP showed excellent correlation with the ASDAS-ESR and ASDAS-CRP respectively (r²=0.78 and 0.58 respectively; p<0.0001). SASDAS-ESR showed good correlation with back pain (r=0.19), morning stiffness (r=0.21), peripheral pain (r=0.21), and CRP (r=0.50); SASDAS-CRP showed good correlation with BASFI (r=0.32), and ESR (r=0.55) (all p<0.0001). Using established ASDAS cut-off values, the corresponding cut-off points between inactive disease, moderate disease activity, high disease activity, and very high disease activitywith optimum sensitivity and specificity for SASDAS-ESR were 1.83, 2.45 and 4.45; the corresponding points for SASDAS-CRP were 0.79, 1.50, and 3.26. While SASDAS-ESR agreed with ASDAS-ESR in the extremes of the condition only, SASDAS-CRP agreed with ASDAS-CRP throughout the range of disease activity. Both the SASDAS scores showed excellent correlation with BASDAI scores.

Conclusion:

SASDAS-ESR and SASDAS-CRP are reliable scores for assessment of disease activity in Indian AS patients. These are easy to calculate and can be useful in daily clinical practice in resource constraint countries.

Disclosure: N. Bansal, None; L. Duggal, None; N. Jain, None; A. Dua, None; A. Patil, None.

To cite this abstract in AMA style:

Bansal N, Duggal L, Jain N, Dua A, Patil A. Validity of Simplified Ankylosing Spondylitis Disease Activity Scores (SASDAS) in Indian As Patients [abstract]. Arthritis Rheumatol. 2015; 67 (suppl 10). https://acrabstracts.org/abstract/validity-of-simplified-ankylosing-spondylitis-disease-activity-scores-sasdas-in-indian-as-patients/. Accessed .

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