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Abstract Number: 2904

Utility of Untimed Single Urine Protein/Creatinine Ratio As a Substitute for the 24 Hour Proteinuria for the Assessment of Proteinuria in Systemic Lupus Erythematosus

Jorge Medina-Rosas1, Dafna Gladman2, Jiandong Su2, Arthy Sabapathy3 and Murray Urowitz2,4, 1Medicine, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, 2Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, 3University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, 4Rheumatology, U of Toronto, Toronto Western Hospital, Toronto, ON, Canada

Meeting: 2015 ACR/ARHP Annual Meeting

Date of first publication: September 29, 2015

Keywords: proteinuria and systemic lupus erythematosus (SLE)

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Session Information

Date: Tuesday, November 10, 2015

Session Title: Systemic Lupus Erythematosus - Clinical Aspects and Treatment Poster Session III

Session Type: ACR Poster Session C

Session Time: 9:00AM-11:00AM

Background/Purpose: To determine the
utility of an untimed Sample of Urine Protein/Creatinine ratio (S-UPCR) as a
screening test for proteinuria and its ability to accurately measure the level
of proteinuria in Systemic Lupus Erythematosus (SLE).

Methods:
Analysis
was performed on the data available from a single SLE cohort between May
2008-December 2014. Proteinuria was measured in a 24 hour urine sample
collection (24H-P) and with the S-UPCR. Based on the 24H-P, samples were
divided into: Group I: < 0.5, group II: 0.5-0.99, group III: 1-1.99, and
group IV: ≥2g/day. Correlation between 24H-P and S-UPCR was measured.
Agreement was determined by Intraclass Correlation Coefficient (ICC),
Concordance Correlation Coefficient (CCC) and Bland-Altman plot between 24H P/C
and S-UPCR. The best cut-offs for S-UPCR predicting a 24H-P of 0.5, 1.0 and 2.0
g/day were determined with the receiver operating characteristics curve.

Results:
The correlation of 24H-P and S-UPCR for all the samples overall was
high, but the correlation for groups I, II, III and IV was low-moderate. The
agreement for all urine samples overall was appropriate but poor for groups I,
II, III and IV. On the Bland-Altman plot, the dots corresponding for groups III
and IV are outside 2 Standard Deviations signifying poor agreement (Figure 1). S-UPCR
cut-offs for 24H-P of 0.5, 1.0 and 2.0 g/day were 0.08, 0.16 and 0.35 g/mmol

Conclusion:
S-UPCR
can be used as a screening test for proteinuria, and the best cut off value to
predict a 24H-P of 0.5 g/day is 0.08 g/mmol (800 mg/g). S-UPCR is not a valid
test to quantify proteinuria. The accurate level of proteinuria should be
measured by the gold standard test, 24H-P.

 

Figure
1.
Bland-Altman
plot for 24H-P/creatinine content and S-UPCR

 


Disclosure: J. Medina-Rosas, None; D. Gladman, None; J. Su, None; A. Sabapathy, None; M. Urowitz, None.

To cite this abstract in AMA style:

Medina-Rosas J, Gladman D, Su J, Sabapathy A, Urowitz M. Utility of Untimed Single Urine Protein/Creatinine Ratio As a Substitute for the 24 Hour Proteinuria for the Assessment of Proteinuria in Systemic Lupus Erythematosus [abstract]. Arthritis Rheumatol. 2015; 67 (suppl 10). https://acrabstracts.org/abstract/utility-of-untimed-single-urine-proteincreatinine-ratio-as-a-substitute-for-the-24-hour-proteinuria-for-the-assessment-of-proteinuria-in-systemic-lupus-erythematosus/. Accessed December 8, 2019.
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