ACR Meeting Abstracts

ACR Meeting Abstracts

Abstract Number: 0872

Usage of Corticosteroids and Hospitalisation Duration in Adult Patients with Systemic Lupus Erythematosus (SLE) in Latvia

Ilze Vinkalna1, Inita Bulina2, Natalija Vellere2, Kristine Ivanova2, Pauls Rubins2, Renate Diura2, Santa Mikena2, Julija Zepa2 and Daina Andersone2, 1Pauls Stradins Clinical University Hospital, Rīga, Latvia, 2Pauls Stradins Clinical University Hospital, Riga

Meeting: ACR Convergence 2020

Keywords: ,

Session Information

Date: Saturday, November 7, 2020

Title: SLE – Treatment Poster I

Session Type: Poster Session B

Session Time: 9:00AM-11:00AM

Background/Purpose: To determine the factors influencing hospitalisation duration, re – hospitalisation (more than 1 hospitalisation during the study period), frequency of the usage of corticosteroids (CS) and its correlation with SLEDAI, SLICC/ACR DI of systemic lupus erythematosus (SLE) patients.

Methods: A retrospective study performed from 01 January 2018 till 31 December 2019 analysed the data of 80 SLE patients, including hospitalisation episodes, in Pauls Stradins Clinical University Hospital.

Results: 70 (87.5 %) patients were females and 10 (12.5%) males. 44 (55 %) patients were admitted to the hospital due to SLE flare and 5 (6.3%) patients due to a new onset of SLE. The mean duration of hospitalisation was 6.8 days (SD 4,9). CS (the mean dosage of prednisolone was 12.6 mg (SD 16.1)) was used in 54 (67.5%) patients before hospitalisation. The proportion of re-hospitalised patients was higher among CS users in comparison with CS non-users (61.1% (n = 33) vs. 26.9% (n=7), p = 0.004). CS users were hospitalised due to infection in 9.3% vs. 0.0% in non-users. An overall infection rate as the reason of hospitalisation was increased in 24.4% CS users vs. 3.8% non-users, p< 0.05. The dose of CS correlated with SLICC/ACR DI (r=0.363, p=0.001), but did not correlate with SLEDAI (r=-0.192, p=0.089). Duration of hospitalisation was longer in case of infection (11.4 vs. 5.9 days, p = 0.000), serositis (9.4 vs. 6.2 days, p = 0.018), fever (8.9 vs. 4.7 days, p = 0.004) and neurolupus (7.4 vs. 3.4 days, p = 0.008). Hospitalisation duration had correlation with ESR (r = 0.284, p = 0.012), CRP (r = 0.323, p = 0.003), SLEDAI (r = 0.237, p =0.034),  total count of leukocytes (r = -0.317, p = 0.004), and neutrophils (r = -0.287, p = 0.01).

Conclusion: The most common cause of hospitalisation in SLE patients was a flare. More than half of SLE patients in long-term treament received CS with higher rate of hospitalisation and re-hospitalisation within a year due to infection.

Disclosure: I. Vinkalna, None; I. Bulina, None; N. Vellere, None; K. Ivanova, None; P. Rubins, None; R. Diura, None; S. Mikena, None; J. Zepa, None; D. Andersone, None.

To cite this abstract in AMA style:

Vinkalna I, Bulina I, Vellere N, Ivanova K, Rubins P, Diura R, Mikena S, Zepa J, Andersone D. Usage of Corticosteroids and Hospitalisation Duration in Adult Patients with Systemic Lupus Erythematosus (SLE) in Latvia [abstract]. Arthritis Rheumatol. 2020; 72 (suppl 10). https://acrabstracts.org/abstract/usage-of-corticosteroids-and-hospitalisation-duration-in-adult-patients-with-systemic-lupus-erythematosus-sle-in-latvia/. Accessed .

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