ACR Meeting Abstracts

ACR Meeting Abstracts

Abstract Number: 2095

Two Novel Serum Urate Levels Associated Genetic Loci Identified By GWAS in European Were Confirmed in Chinese Han Population

Minhui Hua1, Wenfeng Tan2 and Miaojia Zhang3, 1the first affliated hospital with Nanjing medical university, nanjing, China, 2RHEUMATOLOGY DEPT. 300 GUANGZH, THE FIRST AFFILIATED HOSPITAL OF NANJING MEDI, NANJING, China, 3the first affliated hospital with nanjing medical univercity, nanjing, China

Meeting: 2014 ACR/ARHP Annual Meeting

Keywords:

Session Information

Title: Genetics, Genomics and Proteomics

Session Type: Abstract Submissions (ACR)

Background/Purpose

Previous GWAS have identified four novel loci (SNP rs11264341, rs6770152, rs2941484 and rs7224610) were significant with serum urate levels in European . Here, we further assess the association of these 4 loci in the phenotypic expression of hyperuricemia in Chinese Han population.

Methods

A total of 1341 unrelated participants (701 hyeruricemia participants and 640 healthy individuals) were enrolled into our study．All individuals of this study participated from Jiangsu and Anhui Province. DNA samples were genotyped using TaqMan probes that specifically target the alternate alleles. We used χ2-test to determine whether the genotypes of cases and controls of all SNPs deviated from Hardy-Weinberg equilibrium. Differences in allele frequencies between dichotomous traits were calculated employing the same method. Differences in continuous variables between groups were calculated using a two-tailed unpaired t-test. Power analysis was carried out using QUANTO1.2.4.

Results

SNP rs11264341 and rs7224610 were newly discoverred susceptible loci in mainland Chinese Han hyperuriccemia population. The distributions of SNP rs11264341 and rs7224610 were significantly different in hyperuricemia participants and healthy controls. The study also confirmed the association of SNP rs11264341 and rs7224610 with hyperuricemia (p<0.05) in Chinese Han population. C-allele in SNP rs11264341 seemed to be a risk factor in the influence of serum uric acid level. C-allele in SNP rs7224610 played a role of protection in the mean serum urate concentration (p<0.05).

Conclusion

This study confirmed 2 newly SNP rs11264341 and SNP rs7224610 were significant associated hyperuricemia susceptibly in Chinese Han and the genetic variation of these two SNPs could affect the serum urate concentration in Chinese Han population.

Disclosure:

M. Hua,
None;

W. Tan,
None;

M. Zhang,
None.

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