Trabecular Bone Score Is Severely Affected in Male Patients with Chronic Obstructive Pulmonary Disease

Marta Arévalo Salaet¹, Enrique Casado Burgos¹, M Gallego¹, Luis Del Rio², Marta Larrosa³ and Jordi Gratacos⁴, ¹Hospital Universitari Parc Taulí, Sabadell, Spain, ²CETIR Medical Centre, Terrassa, Spain, ³Rheumatology, Hospital Parc Taulí, Sabadell, Spain, ⁴Rheumatology, Hospital de Sabadell, Sabadell, Spain

Meeting: ACR/ARHP Annual Meeting 2015

Date of first publication: September 29, 2015

Keywords: Copd and osteoporosis

Session Information

Date: Sunday, November 8, 2015

Title: Osteoporosis and Metabolic Bone Disease - Clinical Aspects and Pathogenesis Poster

Session Type: ACR Poster Session A

Session Time: 9:00AM-11:00AM

Background/Purpose:

Patients with chronic obstructive pulmonary disease (COPD) have a high risk of osteoporosis and fractures. In a cohort of male patients with COPD we reported 33% of vertebral fractures, with 27% of fractures in patients with normal bone mineral density (BMD)¹. Trabecular Bone Score (TBS) has been described as an index of bone microarquitecture, and could be a new assessment tool to detect bone quality impairment in these patients.

Analysis of TBS in a sub-cohort of male patients with COPD and its possible association with BMD, corticoid use, COPD severity or vertebral fractures.

¹Casado E, et al. JBMR 2007; 22 (S1): S202.

Methods:

Male patients, older than 50 years, with COPD defined according to ATS/ERS classification (FEV₁/FVC<70%) were included. Exclusion criteria: Other concomitant pulmonary disease, rheumatologic and/or vertebral disease that may lead to missinterpretation of BMD by DXA. BMD was determined by dual-energy X-ray absorptiometry (DXA) at lumbar spine and proximal femur. Vertebral fractures were assessed by thoracic and lumbar X-ray. Corticosteroid use in the previous five years and number of hospitalizations were recorded in all patients.

Results:

We included 98 patients. Mean age 67.8±7.5 years. 38% patients had a mild pulmonar disease, 39% moderate and 23% had a severe disease ((FEV₁/FVC<30%). 29 patients (30%) had morphometric vertebral fractures. Mean BMD T-score at lumbar spine -1.67±1.55, at femoral neck -1.81±1.04, and al total hip -1.31±1.14. Mean TBS was 1.035±0,135 (T-score -2.85±1.18). TBS was lower in fractured patients (T -2.59±1.16 vs -2.34±1.22; p=NS). According to COPD severity TBS was lower in patients with modereate disease (T-2.57±1.34) and severe disease (T -2.54±1.34) than in patients with mild disease (T -2.19±1.32), although without reaching significant differences. We didn’t find any significant assotiation between TBS and corticosteroid use.

Conclusion:

TBS is severely affected in male patients with chronic obstructive pulmonary disease, especially in patients with moderate and severe pulmonar disease. Low TBS seems to be associated with vertebral fractures in this population.

Disclosure: M. Arévalo Salaet, None; E. Casado Burgos, None; M. Gallego, None; L. Del Rio, None; M. Larrosa, None; J. Gratacos, None.

To cite this abstract in AMA style:

Arévalo Salaet M, Casado Burgos E, Gallego M, Del Rio L, Larrosa M, Gratacos J. Trabecular Bone Score Is Severely Affected in Male Patients with Chronic Obstructive Pulmonary Disease [abstract]. Arthritis Rheumatol. 2015; 67 (suppl 10). https://acrabstracts.org/abstract/trabecular-bone-score-is-severely-affected-in-male-patients-with-chronic-obstructive-pulmonary-disease/. Accessed .

ACR Meeting Abstracts - https://acrabstracts.org/abstract/trabecular-bone-score-is-severely-affected-in-male-patients-with-chronic-obstructive-pulmonary-disease/