ACR Meeting Abstracts

ACR Meeting Abstracts

  • Home
  • Meetings Archive
    • ACR Convergence 2022
    • ACR Convergence 2021
    • ACR Convergence 2020
    • 2020 ACR/ARP PRSYM
    • 2019 ACR/ARP Annual Meeting
    • 2018 ACR/ARHP Annual Meeting
    • 2017-2009 Meetings
    • Download Abstracts
  • Keyword Index
  • Advanced Search
  • Your Favorites
    • Favorites
    • Login
    • View and print all favorites
    • Clear all your favorites
  • Meeting Resource Center

Abstract Number: 2308

Thigh Muscle MRI Reveals Extensive Muscle Edema and Early Fatty Replacement in Patients with Immune-Mediated Necrotizing Myopathy

Iago Pinal-Fernandez1, Maria Casal-Dominguez2, John A. Carrino3, Arash Lahoutiharahdashti2, Pari Basharat4, Jemima Albayda2, Julie J. Paik2, Shivani Ahlawat5, Sonye K. Danoff6, Thomas E. Lloyd7, Andrew Mammen8 and Lisa Christopher-Stine6, 1Muscle Diseases Unit, National Institute of Arthritis and Musculoskeletal and Skin Diseases. National Institutes of Health, Bethesda, MD, 2Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, 3Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, 4Rheumatology, University of Western Ontario, London, ON, Canada, 5Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, 6Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, 7Neurology, Johns Hopkins, Baltimore, MD, 8National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD

Meeting: 2016 ACR/ARHP Annual Meeting

Date of first publication: September 28, 2016

Keywords: dermatomyositis and polymyositis, Immune-mediated Necrotizing Myopathy, Inclusion body myositis, MRI

  • Tweet
  • Email
  • Print
Session Information

Date: Tuesday, November 15, 2016

Session Title: Muscle Biology, Myositis and Myopathies - Poster II: Clinical

Session Type: ACR Poster Session C

Session Time: 9:00AM-11:00AM

Background/Purpose: The aim of this study was to define the pattern of muscle involvement in patients with immune-mediated necrotizing myopathy (IMNM).

Methods: All Johns Hopkins Myositis Longitudinal Cohort subjects with an available thigh magnetic resonance imaging (tMRI) who fulfilled criteria for IMNM, dermatomyositis (DM), polymyositis (PM), clinically amyopathic DM (CADM) or inclusion body myositis (IBM) were included in the study. Fifteen muscles were assessed by tMRI for the presence or absence of edema, atrophy, fatty replacement, and fascial edema. Disease subgroups were compared using univariate and multivariate analysis. Within IMNM, patients with anti-SRP and anti-HMGCR were also compared.

Results: The study included 666 subjects (101 IMNM, 176 PM, 219 DM, 17 CADM and 153 IBM). Compared to patients with DM or PM, IMNM was characterized by a higher proportion of thigh muscles with edema, atrophy, and fatty replacement (p<0.01), independent of other confounding variables. Compared with anti-SRP, anti-HMGCR patients showed a lesser proportion of muscles with atrophy (-9%, p=0.04). In IMNM, muscle abnormalities were especially common in the lateral rotator and gluteal groups. Fascial involvement was more widespread in DM. Interestingly, fatty replacement of muscle tissue began early during the course of IMNM as well as the other muscle diseases. Although it had a negative predictive value of 93%, an optimal combination of tMRI features had only a 55% positive predictive value for diagnosing IMNM.

Conclusion: Compared to patients with DM or PM, IMNM is characterized by more widespread muscle involvement. Compared with anti-HMGCR, anti-SRP patients seem to have more severe muscle involvement.


Disclosure: I. Pinal-Fernandez, None; M. Casal-Dominguez, None; J. A. Carrino, None; A. Lahoutiharahdashti, None; P. Basharat, None; J. Albayda, None; J. J. Paik, None; S. Ahlawat, None; S. K. Danoff, None; T. E. Lloyd, None; A. Mammen, None; L. Christopher-Stine, None.

To cite this abstract in AMA style:

Pinal-Fernandez I, Casal-Dominguez M, Carrino JA, Lahoutiharahdashti A, Basharat P, Albayda J, Paik JJ, Ahlawat S, Danoff SK, Lloyd TE, Mammen A, Christopher-Stine L. Thigh Muscle MRI Reveals Extensive Muscle Edema and Early Fatty Replacement in Patients with Immune-Mediated Necrotizing Myopathy [abstract]. Arthritis Rheumatol. 2016; 68 (suppl 10). https://acrabstracts.org/abstract/thigh-muscle-mri-reveals-extensive-muscle-edema-and-early-fatty-replacement-in-patients-with-immune-mediated-necrotizing-myopathy/. Accessed January 28, 2023.
  • Tweet
  • Email
  • Print

« Back to 2016 ACR/ARHP Annual Meeting

ACR Meeting Abstracts - https://acrabstracts.org/abstract/thigh-muscle-mri-reveals-extensive-muscle-edema-and-early-fatty-replacement-in-patients-with-immune-mediated-necrotizing-myopathy/

Advanced Search

Your Favorites

You can save and print a list of your favorite abstracts during your browser session by clicking the “Favorite” button at the bottom of any abstract. View your favorites »

ACR Pediatric Rheumatology Symposium 2020

© COPYRIGHT 2023 AMERICAN COLLEGE OF RHEUMATOLOGY

Wiley

  • Home
  • Meetings Archive
  • Advanced Search
  • Meeting Resource Center
  • Online Journal
  • Privacy Policy
  • Permissions Policies
  • Cookie Preferences