Session Information
Date: Tuesday, November 9, 2021
Session Title: Vasculitis – Non-ANCA-Associated & Related Disorders Poster II (1862–1888)
Session Type: Poster Session D
Session Time: 8:30AM-10:30AM
Background/Purpose: Gastrointestinal involvement (GI) is associated with significant morbidity in acute IgA vasculitis (IgAV). Besides the abdominal pain, bowel ischemia could lead to bleeding, perforation, or ileus among others. Our aim was to investigate the role of faecal calprotectin measurement in patients with adult IgAV.
Methods: Faecal calprotectin was determined at presentation in 70 patients with histologically proven adult IgAV diagnosed at our secondary/tertiary rheumatology center. Based on the calprotectin level, patients were stratified into two groups – those with elevated vs. normal level (the cut off >50 μg/g). Clinical features of patients with elevated vs. normal faecal calprotectin were compared. Logistic regression was used to determine factors associated with elevated faecal calprotectin in IgAV.
Results: Our cohort consisted of 45 males (64.3%) and 25 females (35.7%), median (IQR) age 63.9 (45.9; 69.2) years, with median (IQR) IgAV symptom duration time 7 (4; 21) days. Seventeen patients (24.3%) had GI involvement (abdominal pain, overt GI bleeding, occult GI bleeding, diarrhoea, ileus developed in 15, 4, 12, 6 and 1 patient, respectively). Twenty-eight out of 70 patients (40.0%) had elevated faecal calprotectin, with median (IQR) level of 86.3 (64.0; 192.8) μg/g, of them 8 had clinically GI involvement. We found no significant association between clinical GI involvement and elevated faecal calprotectin (p=0.574). Characteristics of IgAV patients with elevated vs. normal faecal calprotectin are presented in Table 1. Multivariate analysis showed that elevated calprotectin was associated with increasing patient age (OR 1.04 (95%CI 1.01-1.08); p=0.018), purpura above waistline (OR 3.37 (95%CI 1.07-10.58); p=0.037) and C-reactive protein (OR 1.02 (95%CI 1.00-1.03); p=0.017
Conclusion: Our result show that the role of faecal calprotectin measurements in evaluating GI involvement adult IgAV is rather limited.
Table 1. Characteristics of IgA vasculitis patients with elevated vs. normal fecal calprotectin
To cite this abstract in AMA style:
Hocevar A, Bajzelj M, Tomšič M, Lakota K. The Role of Faecal Calprotectin in IgA Vasculitis [abstract]. Arthritis Rheumatol. 2021; 73 (suppl 9). https://acrabstracts.org/abstract/the-role-of-faecal-calprotectin-in-iga-vasculitis/. Accessed September 25, 2022.« Back to ACR Convergence 2021
ACR Meeting Abstracts - https://acrabstracts.org/abstract/the-role-of-faecal-calprotectin-in-iga-vasculitis/