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Abstract Number: 240

The Relationship Between Serum Cholinesterase, Number of Organ Involvement and Fibrotic Markers in Japanese Patients with IgG4-Related Disease

Satoshi Inotani1, Yoshinori Taniguchi2, Mitsuhiro Kawano3, Natsuki Maeda4, Hirofumi Nishikawa5, Mio Matsuura5, Kosuke Inoue6, Taro Horino5, Shimpei Fujimoto5 and Yoshio Terada6, 1Rheumatic Disease Center, Kurashiki Medical Center, Kurashiki, Japan, 2Endocrinology, Metabolism,Nephrology and Rheumatology, Kochi University, Kochi, Japan, 3Division of Rheumatology, Kanazawa University Graduate School of Medicine, Kanazawa, Japan, 4Endocrinology,Metabolism,Nephrology and Rheumatology, Kochi Medical School, Nankoku, Japan, 5Endocrinology, Metabolism, Nephrology and Rheumatology, Kochi Medical School, Nankoku, Japan, 6Kochi University, Nankoku, Japan

Meeting: ACR/ARHP Annual Meeting 2016

Date of first publication: September 28, 2016

Keywords:

Session Information

Date: Sunday, November 13, 2016

Title: Miscellaneous Rheumatic and Inflammatory Diseases - Poster I

Session Type: ACR Poster Session A

Session Time: 9:00AM-11:00AM

Background/Purpose:  To evaluate the relationship between serum cholinesterase (ChE) level, number of organ involvement, serum fibrotic markers and imaginational outcome in Japanese patients with IgG4-related disease (IgG4-RD).

Methods:  The clinical symptoms, laboratory, pathological and FDG-PET/CT findings of Japanese patients with IgG4-RD (n=20) were assessed. Several laboratory data of IgG4-RD with multiple organs’ involvements (IM) (n=10), IgG4-RD with limited organ’s involvement (IL) (n=10), ANCA-associated vasculitis (AAV) (n=10) and Sjogren syndrome (SjS) (n=10) were comparatively examined. Furthermore, we studied the relationship between the numbers of organ involvement (NOI), several fibrotic markers (ELF score and serum Dkk-1) and imaginational outcome in IgG4-RD group.

Results:  Serum ChE levels were significantly lower in IM group than IL, AAV and SjS groups. In total IgG4-RD cases, ChE levels inversely correlated with NOI and fibrotic score, and fibrotic score positively correlated with NOI. Finally, Dkk-1, one of Wnt inhibitors, levels in IM were significantly lower than IL and healthy subjects (p<0.05). Moreover, low level of Dkk-1 before and after treatment tended to predict the progression of organ atrophy.

Conclusion: The ELF score and serum Dkk-1 level might be clinically useful indicators of active fibrosis and the extent of IgG4-RD. Notably, continuous lower levels of Dkk-1 were related to organ atrophy and serum ChE levels could predict these phenomena.

Disclosure: S. Inotani, None; Y. Taniguchi, None; M. Kawano, None; N. Maeda, None; H. Nishikawa, None; M. Matsuura, None; K. Inoue, None; T. Horino, None; S. Fujimoto, None; Y. Terada, None.

To cite this abstract in AMA style:

Inotani S, Taniguchi Y, Kawano M, Maeda N, Nishikawa H, Matsuura M, Inoue K, Horino T, Fujimoto S, Terada Y. The Relationship Between Serum Cholinesterase, Number of Organ Involvement and Fibrotic Markers in Japanese Patients with IgG4-Related Disease [abstract]. Arthritis Rheumatol. 2016; 68 (suppl 10). https://acrabstracts.org/abstract/the-relationship-between-serum-cholinesterase-number-of-organ-involvement-and-fibrotic-markers-in-japanese-patients-with-igg4-related-disease-2/. Accessed .

ACR Meeting Abstracts - https://acrabstracts.org/abstract/the-relationship-between-serum-cholinesterase-number-of-organ-involvement-and-fibrotic-markers-in-japanese-patients-with-igg4-related-disease-2/