Session Title: Miscellaneous Rheumatic and Inflammatory Diseases - Poster I
Session Type: ACR Poster Session A
Session Time: 9:00AM-11:00AM
Background/Purpose: To evaluate the relationship between serum cholinesterase (ChE) level, number of organ involvement, serum fibrotic markers and imaginational outcome in Japanese patients with IgG4-related disease (IgG4-RD).
Methods: The clinical symptoms, laboratory, pathological and FDG-PET/CT findings of Japanese patients with IgG4-RD (n=20) were assessed. Several laboratory data of IgG4-RD with multiple organs’ involvements (IM) (n=10), IgG4-RD with limited organ’s involvement (IL) (n=10), ANCA-associated vasculitis (AAV) (n=10) and Sjogren syndrome (SjS) (n=10) were comparatively examined. Furthermore, we studied the relationship between the numbers of organ involvement (NOI), several fibrotic markers (ELF score and serum Dkk-1) and imaginational outcome in IgG4-RD group.
Results: Serum ChE levels were significantly lower in IM group than IL, AAV and SjS groups. In total IgG4-RD cases, ChE levels inversely correlated with NOI and fibrotic score, and fibrotic score positively correlated with NOI. Finally, Dkk-1, one of Wnt inhibitors, levels in IM were significantly lower than IL and healthy subjects (p<0.05). Moreover, low level of Dkk-1 before and after treatment tended to predict the progression of organ atrophy.
Conclusion: The ELF score and serum Dkk-1 level might be clinically useful indicators of active fibrosis and the extent of IgG4-RD. Notably, continuous lower levels of Dkk-1 were related to organ atrophy and serum ChE levels could predict these phenomena.
To cite this abstract in AMA style:Inotani S, Taniguchi Y, Kawano M, Maeda N, Nishikawa H, Matsuura M, Inoue K, Horino T, Fujimoto S, Terada Y. The Relationship Between Serum Cholinesterase, Number of Organ Involvement and Fibrotic Markers in Japanese Patients with IgG4-Related Disease [abstract]. Arthritis Rheumatol. 2016; 68 (suppl 10). https://acrabstracts.org/abstract/the-relationship-between-serum-cholinesterase-number-of-organ-involvement-and-fibrotic-markers-in-japanese-patients-with-igg4-related-disease-2/. Accessed February 23, 2020.
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