The Prevalence of Rheumatoid Arthritis and Allergic Diseases and Their Association : A Study of the Korean National Health and Nutrition Examination Survey (KNHANES)

Sang Hyun Joo¹, Eun Hye Park², Joongyub Lee³ and Yeong Wook Song^2,4, ¹Division of Rheumatology, Department of Internal Medicine, Jungang Medical Foundation, Jeju, Korea, Republic of (South), ²Division of Rheumatology, Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea, Republic of (South), ³Division of Clinical Epidemiology Medical Research Collaborating Center Biomedical Research Institution, Seoul National University Hospital, Seoul, Korea, Republic of (South), ⁴Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, Korea., Seoul, Korea, Republic of (South)

Meeting: 2017 ACR/ARHP Annual Meeting

Date of first publication: September 18, 2017

Keywords: Rheumatoid arthritis (RA)

Session Information

Date: Tuesday, November 7, 2017

Title: Epidemiology and Public Health Poster III: Rheumatic Disease Risk and Outcomes

Session Type: ACR Poster Session C

Session Time: 9:00AM-11:00AM

Background/Purpose:

Allergy and autoimmune disease are related to the immune system. It was not clear in the previous studies whether allergic disease (e.g., asthma, allergic rhinitis, and atopic dermatitis) are associated with rheumatoid arthritis (RA).

Methods:

We analyzed RA, allergic disease (asthma, allergic rhinitis, and atopic dermatitis) and the serum immunoglobulin E (IgE) against inhalant antigen (total IgE, IgE Dermatophagoides farina (df), IgE cockroach and IgE dog) from the data of KNHANES (N=8958, estimated population size=47933924). We analyzed the prevalence of RA and allergic diseases using general linear model and logistic regression with complex sample design method adjusted by age and sex and evaluated the association between RA and allergic diseases including serum IgE levels.

Results:

The prevalence of RA was 2.22 % [95% CI; 1.46-3.38]. The prevalence of allergic diseases was 22.89% [95% CI: 20.61-25.35]. The prevalence of RA with allergic disease (2.63 % [95% CI;1.68-4.10]) were significantly increased compared with that of RA without allergic diseases (1.91 % [95% CI; 0.99-3.67]) (p =0.02). Asthma (adjusted odds ratio (OR): 2.60 [1.89-3.58], p<0.001) and atopic dermatitis (adjusted OR: 2.22 [1.81-2.73], p<0.001]) were positively associated with RA.

Total IgE levels were increased in RA patients (RA vs. control: 561.99 ± 286.98 kU/L vs. 269.17 ± 16.37 kU/L, p=0.04). But serum IgE df were decreased in RA patients (RA vs. control: 1.39 ± 0.63 kU/L vs. 5.09 ± 0.43 kU/L, p<0.01). Serum IgE cockroach level (RA vs. control: 1.39 ± 0.87 kU/L vs. 0.52 ± 0.05 kU/L, p=0.06) and serum IgE dog levels (RA vs. control: 0.10 ± 0.04 kU/L vs. 0.34 ± 0.12 kU/L, p=0.15) were not different.

Conclusion:

We showed increased prevalence of RA patients in the individuals with the allergic diseases than those without allergic diseases. Serum total IgE levels was increased in RA patients of the KNHANES data of Korean populations.

Disclosure: S. H. Joo, None; E. H. Park, None; J. Lee, None; Y. W. Song, None.

To cite this abstract in AMA style:

Joo SH, Park EH, Lee J, Song YW. The Prevalence of Rheumatoid Arthritis and Allergic Diseases and Their Association : A Study of the Korean National Health and Nutrition Examination Survey (KNHANES) [abstract]. Arthritis Rheumatol. 2017; 69 (suppl 10). https://acrabstracts.org/abstract/the-prevalence-of-rheumatoid-arthritis-and-allergic-diseases-and-their-association-a-study-of-the-korean-national-health-and-nutrition-examination-survey-knhanes/. Accessed .

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