Session Type: ACR Poster Session A
Session Time: 9:00AM-11:00AM
Methods: All IMID patients commencing biological treatment from May 2012 through July 2015, were included. Screening consisted of a detailed medical history on risk factors for LTBI (e.g. previous diagnosis of TBC, close contact with a TBC-infected person, previous living outside Europe, North-America and/or Australia) and HBV infection (occupation, history of intravenous drug abuse, sexual behaviour), a Quantiferon test (QFT), serology for HBV (HBs-Ag, anti HB-core) and a
Results: In total, 547 of 549 patients (99.6%) starting biological therapy were screened. One patient (0.2%) tested positive for HBV without having reported any risk factor. Table 1 shows that 22 patients (4.0%) tested positive on QFT and were classified as LTBI patients. Of these, 14 did not report any risk factor, 18 had always lived in The Netherlands and 18 had never travelled outside of Europe, North America or Australia. Four patients had abnormalities on chest X-ray, 3 of them also tested positive on QFT and the other one turned out to have sarcoidosis, not LTBI. All LTBI patients were treated with isoniazid therapy. After a mean follow-up period of 19.8 ±8.8 months none of the patients had a reactivation of LTBI after the start of biological therapy.
|Medical history, N (%) Risk factors No risk factors||
|Chest X-ray, N (%) Positive Negative||
Conclusion: The overall prevalence of LTBI and HBV in patients
To cite this abstract in AMA style:de Jong M, Roosen D, Peters A, Verstraeten V, Pierik M, van Tubergen A. The Prevalence of Latent Tuberculosis and Hepatitis B Found after Systematic Screening of Patients Starting with Biological Therapy in a Low-Endemic Area [abstract]. Arthritis Rheumatol. 2016; 68 (suppl 10). https://acrabstracts.org/abstract/the-prevalence-of-latent-tuberculosis-and-hepatitis-b-found-after-systematic-screening-of-patients-starting-with-biological-therapy-in-a-low-endemic-area/. Accessed July 31, 2021.
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ACR Meeting Abstracts - https://acrabstracts.org/abstract/the-prevalence-of-latent-tuberculosis-and-hepatitis-b-found-after-systematic-screening-of-patients-starting-with-biological-therapy-in-a-low-endemic-area/