The Prevalence of Autoimmune Disease in Families of Patients with Systemic Lupus Erythematosus (SLE). a Single Centre Study

Oseme Etomi¹, Andrea Cove-Smith², Ravindra Rajakariar³, Myles J. Lewis^2,4,5,6, Angela Pakozdi² and Debasish Pyne², ¹heumatology Department, Barth Health NHS foundation trust, London, United Kingdom, ²Barts Lupus Centre, Barts Health NHS Trust, London, United Kingdom, ³Bart's Lupus Center, Barts Health NHS Foundation Trust, London, United Kingdom, ⁴Experimental Medicine & Rheumatology, Queen Mary University of London, London, United Kingdom, ⁵Myles Lewis ([email protected]), London, United Kingdom, ⁶Rheumatology, Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Barts and The London, School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom

Meeting: 2017 ACR/ARHP Annual Meeting

Date of first publication: September 18, 2017

Keywords: autoimmune diseases, Family studies and systemic lupus erythematosus (SLE)

Session Information

Date: Tuesday, November 7, 2017

Title: Systemic Lupus Erythematosus – Clinical Aspects and Treatment Poster III: Therapeutics and Clinical Trial Design

Session Type: ACR Poster Session C

Session Time: 9:00AM-11:00AM

Background/Purpose:

Studies to date have reported that up to 30% of lupus patient have a first degree relative with an autoimmune disorder (AD). The most recent study from the Danish registry (1) reports an increase in risk of lupus, rheumatoid arthritis (RA) , type 1 diabetes (T1DM) and inflammatory bowel disease in individuals with an SLE-affected first-degree relative . Here we describe the prevalence of ADs amongst family members in a multi ethnic lupus cohort.

Methods:

Questionnaires were distributed to consecutive lupus patients attending our Lupus clinic between April 2017 and June 2017. All patients fulfilled the 2012 SLICC ACR criteria for lupus. Patients were asked about their family history with specific questions on the presence of a range of ADs.

Results:

74 patients completed questionnaires. 24 were incomplete, the remaining 50 were analysed. The average age of patients with SLE was 41.6years (21- 78) 90% of the patients were female. South east Asians (40%) and afro- Caribbean (36%) represented the majority of our cohort. Others included Caucasian (14%), Turkish (4%), oriental (2%), Malaysian (2%) and one mixed race (2%) Caucasian-afro Caribbean.

13 (26%) patients with SLE had another autoimmune condition with RA the most common (n= 7 ,14%), followed by antiphospholipid syndrome (APS) (n =4 , 8%) , sjogrens (n=1) and hashimotos (n=1).

The prevalence of a second AD in lupus patients was highest in Afro-Caribbeans (n=16, 89%). Afro-Caribbean patients were significantly more likely to have another AD than South East Asians (n=7, 35%) (p=0.001) and Caucasians (n=1, 14%) (p=0.001).

A family history of AD was found in 17 patients (34%). SLE was the most prevalent AD in relatives with 8 cases (16%) identified, followed by RA in 5 (10%), T1DM (n=3), graves’ disease (n=3) and multiple sclerosis (n =2 ). Other AD identified were sjogrens, hashimotos and psoriasis (n=1). In 54% the family history was in a first degree relative, second degree relative in 37.5% and 3^rd degree relatives in 8.3%. The majority of relatives with an autoimmune history were female ( 70.8%). There was no significant difference in the incidence of a family history of autoimmune disease between the various ethnic groups.

Conclusion:

Within our multi ethnic cohort of patients with SLE, RA was the most common second AD followed by APS. Afro-Caribbean were more likely to have a second AD than either south east Asians or Caucasians. SLE, RA, T1DM and Graves’ disease were the most common ADs found in family members. Ethnicity did not affect the likelihood of patients having a relative with an AD. Larger sampling is warranted for future studies.

Disclosure: O. Etomi, None; A. Cove-Smith, None; R. Rajakariar, None; M. J. Lewis, None; A. Pakozdi, None; D. Pyne, None.

To cite this abstract in AMA style:

Etomi O, Cove-Smith A, Rajakariar R, Lewis MJ, Pakozdi A, Pyne D. The Prevalence of Autoimmune Disease in Families of Patients with Systemic Lupus Erythematosus (SLE). a Single Centre Study [abstract]. Arthritis Rheumatol. 2017; 69 (suppl 10). https://acrabstracts.org/abstract/the-prevalence-of-autoimmune-disease-in-families-of-patients-with-systemic-lupus-erythematosus-sle-a-single-centre-study/. Accessed .

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