Session Information
Date: Thursday, May 18, 2017
Session Type: Abstract Submissions
Session Time: 5:30PM-7:00PM
Methods: MSAs (anti-TIF-1, anti-MJ, anti-ARS , and anti-MDA-5), and MAAs were evaluated with above clinical information.
Results: Among 12 JIIM children,MSAs and MAAs were detected in 9 (anti-TIF-1 (n=3), anti-MJ (n=3), anti-MDA-5 (n=2), and anti-ARS (n=1))and 1(anti-Ku). The other two were
negative.Eleven except anti-Ku positive child were consistent with juvenile dermatomyositis.Three patients with anti-TIF-1 mainly had skin
manifestations, 2 of the 3 were diagnosed clinically amyopathic dermatomyositis.Typical skin manifestations and myositis were noted in another 3 patients with anti-MJ.Of the two children with anti-MDA-5, one developed interstitial pneumonia successfully treated intravenous cyclophosphamide pulse therapy,and the other had arthritis intractable to conventional treatments and improved by adalimumab.
Conclusion: The MSAs were highly detected in JIIM patients. Myositis was most severe in anti-MJ positive patients, whereas the skin and extra-skeletal muscles symptoms were mainly noted in patients with anti-TIF-1 and anti-MDA-5.
To cite this abstract in AMA style:
Miyamae T, Kishi T, Yamanaka H. The myositis-specific autoantibody and myositis-associated autoantibody phenotypes in Japanese juvenile idiopathic inflammatory myopathies [abstract]. Arthritis Rheumatol. 2017; 69 (suppl 4). https://acrabstracts.org/abstract/the-myositis-specific-autoantibody-and-myositis-associated-autoantibody-phenotypes-in-japanese-juvenile-idiopathic-inflammatory-myopathies/. Accessed .ACR Meeting Abstracts - https://acrabstracts.org/abstract/the-myositis-specific-autoantibody-and-myositis-associated-autoantibody-phenotypes-in-japanese-juvenile-idiopathic-inflammatory-myopathies/