ACR Meeting Abstracts

ACR Meeting Abstracts

  • Meetings
    • ACR Convergence 2024
    • ACR Convergence 2023
    • 2023 ACR/ARP PRSYM
    • ACR Convergence 2022
    • ACR Convergence 2021
    • ACR Convergence 2020
    • 2020 ACR/ARP PRSYM
    • 2019 ACR/ARP Annual Meeting
    • 2018-2009 Meetings
    • Download Abstracts
  • Keyword Index
  • Advanced Search
  • Your Favorites
    • Favorites
    • Login
    • View and print all favorites
    • Clear all your favorites
  • ACR Meetings

Abstract Number: 1125

The Mitochondrial Genome Influences the Risk of Incident Knee OA. DATA from the Osteoarthritis Initiative

Angel Soto-Hermida1, Ignacio Rego-Pérez1, Juan Fernández-Tajes1, Mercedes Fernandez Moreno1, María Eugenia Vázquez-Mosquera1, Estefanía Cortés-Pereira1, Sonia Pértega-Díaz2, Natividad Oreiro-Villar1, Carlos Fernandez-Lopez1 and Francisco J. Blanco Garcia1, 1Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC), A Coruña, Spain, 2Unidad de Epidemiología Clínica y Bioestadística. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC), A Coruña, Spain

Meeting: 2014 ACR/ARHP Annual Meeting

Keywords: Genome, mitochondria and risk, OA

  • Tweet
  • Click to email a link to a friend (Opens in new window) Email
  • Click to print (Opens in new window) Print
Session Information

Title: Genetics, Genomics and Proteomics II

Session Type: Abstract Submissions (ACR)

Background/Purpose

Previous studies by our group showed a significant influence of the mtDNA haplogroups on both radiographic progression and cartilage integrity of knee OA patients from the Osteoarthritis Initiative (OAI). The aim of this study is to analyze the influence of the mitochondrial variants on the risk of incident knee OA in patients with pre-radiographic OA of the OAI.

Methods

We assessed the mtDNA haplogroups in 2374 Caucasian samples of the OAI to analyze their influence on incident knee OA. Incidence of knee OA was defined as a KL score <2 at baseline and a KL≥2 at 4 years follow-up of the same knee. We also included individuals with unilateral KOA, since they were at risk of developing incident OA at the other knee. Statistical analyses included chi-square contingency tables and logistic regression models considering age, gender, body mass index (BMI), contralateral knee OA and mtDNA variants as variables of interest. Further, the area under the receiving operative characteristic (ROC) curve (AUC) of the model was also calculated.

Results

After 4 years of follow-up, a total of 214 patients developed incident knee OA, meanwhile 1323 did not. The rest of patients (n=837) had a KL score≥2 at baseline in both knees, therefore did not meet the selection criteria and were subsequently excluded from further analyses. Patients belonging to mtDNA cluster HV were significantly overrepresented in the incident knee OA group (OR=1.395; CI=1.044-1.8636; p=0.024) meanwhile patients in cluster TJ were less represented in the incident group (OR=0.692; CI=0.466-1.026;p=0.065). The logistic regression model showed that female gender (p<0.001), higher BMI (p<0.001) and contralateral knee OA (p<0.001) were risk factors to develop incident OA; additionally, OA patients in cluster HV were at higher risk for incident knee OA than patients in cluster TJ (p=0.016). The AUC of this regression model was 0.707

Conclusion

The mitochondrial genome contributes to the development of incident knee OA. The assignment of the mtDNA haplogroups could be used as complementary genetic biomarkers to predict the risk of incident knee OA.


Disclosure:

A. Soto-Hermida,
None;

I. Rego-Pérez,
None;

J. Fernández-Tajes,
None;

M. Fernandez Moreno,
None;

M. E. Vázquez-Mosquera,
None;

E. Cortés-Pereira,
None;

S. Pértega-Díaz,
None;

N. Oreiro-Villar,
None;

C. Fernandez-Lopez,
None;

F. J. Blanco Garcia,
None.

  • Tweet
  • Click to email a link to a friend (Opens in new window) Email
  • Click to print (Opens in new window) Print

« Back to 2014 ACR/ARHP Annual Meeting

ACR Meeting Abstracts - https://acrabstracts.org/abstract/the-mitochondrial-genome-influences-the-risk-of-incident-knee-oa-data-from-the-osteoarthritis-initiative/

Advanced Search

Your Favorites

You can save and print a list of your favorite abstracts during your browser session by clicking the “Favorite” button at the bottom of any abstract. View your favorites »

All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].

Wiley

  • Online Journal
  • Privacy Policy
  • Permissions Policies
  • Cookie Preferences

© Copyright 2025 American College of Rheumatology