Session Title: Rheumatoid Arthritis - Clinical Aspects Poster Session III
Session Type: ACR Poster Session C
Session Time: 9:00AM-11:00AM
Background/Purpose: In course of rheumatoid arthritis (RA) ther is often impaired glucose metabolism, which leads to the development of diabetes mellitus (DM). One of the parameters allowing to assess the risk of DM and cardiovascular disease (CVD) is the concentration of advanced glycation end products (AGE). In rheumatoid arthritis patients increase in the level of AGE also occurs due to the underlying disease. The aim of the study was to assess correlation of AGE skin concentration with other laboraotry tests and to compare the levels of AGE concentration between RA patients and healthy subjects.
Methods: The study involved 148 patients divided into three groups: Group I – patients with RA (n = 102, 79F / 23M, average age 51.5), group II – patients with RA and DM (n = 21, 14F / 7M average age: 51.9), group III – healthy persons (n = 25, 16F / 9M, average age 48.8). Each patient had a skin test using the AGE Reader, which allows the assessment of AGE skin concentration by evaluation of skin autofluorescence (SAF) signal and a laboratory tests panel including total cholesterol, HDL, LDL, triglycerides and HbA1C and the calculated body mass index (BMI).
Results: Average SAF value in arbitrary units [au] was: group I 2.54 au and group II 2.74 au, group III 1.96 au. The average SAF value in the group III differed significantly from the average SAF value in group I and II (p <0.1 and p <0.05 respectively). There was no statistically significant difference between the mean AF values for Groups I and II. Based on AGE Reader tests risk groups of developing DM and CVD can also be separated. Significant differences in the distribution of patients in each risk group between the group III and group I and II (p <0.001) was observed. There was a correlation between an increased SAF value in groups I and II and the following laboratory results compared to the group III: HDL (mean values in the groups were as follows: 60.52 mg/dl, 57.48 mg/dl, 84.08 mg/dl) and Hb1AC (mean values in the groups were respectively 5.5 mm/hr, 5.6 mm/h and 5.3 mm/h) (p <0.01). In case of groups II and III a significant differences between the results of ESR (average values were 24 mm/h and 13 mm/h) and triglycerides concentration (mean values were 135 mg/dl and 95 mg/dL) (p < 0.01. were also observed.
Conclusion: These results confirm that the value of AGE skin concentration is associated with increased RA activity and may be an important indicator in the assessment of disease progression and its potential complications.
To cite this abstract in AMA style:Jeka S, Zuchowski P, Kolossa K, Dura M, Wojciechowski R. The Measurement of the Skin Autofluorescence As an Indicator of Disease Progression in Rheumatoid Arthritis Patients [abstract]. Arthritis Rheumatol. 2015; 67 (suppl 10). https://acrabstracts.org/abstract/the-measurement-of-the-skin-autofluorescence-as-an-indicator-of-disease-progression-in-rheumatoid-arthritis-patients/. Accessed August 13, 2020.
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