ACR Meeting Abstracts

ACR Meeting Abstracts

Abstract Number: 2296

The Influence of Androgen Deprivation Therapy on Serum Uric Acid Level

Jae Hyun Lee1, Eun Hye Park2, Sang Wan Chung3, Jaehyung Hur3, You Jung Ha3, Yeong Wook Song1,4 and Yun Jong Lee5,6, 1Division of Rheumatology, Department of Internal Medicine, Seoul National University Hospital, Seoul, South Korea, 2Division of Rheumatology, Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea, The Republic of, 3Division of Rheumatology, Department of Internal Medicine, Division of Rheumatology, Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, South Korea, 4Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea, 5Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea, 6Division of Rheumatology, Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, South Korea

Meeting: 2016 ACR/ARHP Annual Meeting

Date of first publication: September 28, 2016

Keywords: ,

Session Information

Date: Tuesday, November 15, 2016

Title: Metabolic and Crystal Arthropathies - Poster II: Epidemiology and Mechanisms of Disease

Session Type: ACR Poster Session C

Session Time: 9:00AM-11:00AM

Background/Purpose: The prevalence of hyperuricemia and gout suggests that sex hormones play a role in the gender difference with gout. Estrogen has been thought to reduce serum uric acid levels by increasing renal urate elimination. However, studies on the relationship between testosterone and uric acid levels showed conflicting results. We performed this study to define whether anti-androgen treatment affects serum uric acid levels in men.

Methods: This retrospective study reviewed the medical records of 178 patients who underwent anti-androgen treatment for advanced prostate cancer from January 2004 to December 2013 at Seoul National University Bundang Hospital. We enrolled 92 patients with available pre- and post-treatment (3 or 6-month) uric acid levels among them. An age-matched control included 46 prostate cancer patients who underwent surgical treatment only and had available pre- and post-treatment uric acid levels. The change of serum uric acid levels was compared by generalized estimation equation (GEE) model between patients with and without anti-androgen treatment.

Results: Compared to the control group, patients with anti-androgen treatment showed a more pronounced reduction of uric acid levels at both 3 and 6 months (estimation = -0.765 at 3-month and -0.739 at 6-month after anti-androgen treatment, both p-value < 0.001, Figure 1A). After further adjusting with hemoglobin, blood urea nitrogen, serum creatinine and serum protein levels, the difference was still significant (estimation = -0.831 at 3-month and -0.766 at 6-month, both p-value < 0.001, Figure 1B). When patients were stratified according to pre-treatment uric acid level (uric acid > 7 mg/dL versus <= 7 mg/dL), patients with hyperuricemia showed a more decrease in uric acid levels at 3-month compared to those with normouricemia (estimation = -1.072, p < 0.001, Figure 2).

Conclusion: These results showed that serum uric acid levels significantly decreased after anti-androgen therapy and suggest that male sex hormone could partially explain the gender difference in gout and hyperuricemia prevalence.

Keywords: Uric acid, hyperuricemia, gout, anti-androgen treatment

 

Disclosure: J. H. Lee, None; E. H. Park, None; S. W. Chung, None; J. Hur, None; Y. J. Ha, None; Y. W. Song, None; Y. J. Lee, None.

To cite this abstract in AMA style:

Lee JH, Park EH, Chung SW, Hur J, Ha YJ, Song YW, Lee YJ. The Influence of Androgen Deprivation Therapy on Serum Uric Acid Level [abstract]. Arthritis Rheumatol. 2016; 68 (suppl 10). https://acrabstracts.org/abstract/the-influence-of-androgen-deprivation-therapy-on-serum-uric-acid-level/. Accessed .

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