Session Information
Session Title: Epidemiology and Health Services Research: Epidemiology and Outcomes of Rheumatic Disease II
Session Type: Abstract Submissions (ACR)
Background/Purpose: Patients with more severe cutaneous lupus activity have poorer quality of life. The main objective of the current study was to evaluate the impact that lupus-related disease damage had on skin-specific quality of life and the differences observed within a population of CLE patients from different racial backgrounds with respect to disease damage and its impact on quality of life.
Methods: Patients were enrolled into our prospective database and evaluated with a validated cutaneous lupus-scoring tool (CLASI). Data collected included sex, race, diagnosis, Cutaneous Lupus Area Activity and Severity Index (CLASI) scores, and Skindex-29 QoL scores. These parameters were analyzed at the initial and last visits. CLASI damage scores (dyspigmentation and scarring) and CLASI activity scores were collected, grouped by race, and correlated with Skindex-29 domains.
Results: 223 patients were analyzed at baseline, with 141 of these patients completing more than one study visit. The majority of patients were Caucasians (63.7%), followed by African Americans (29.1%) and Asian Americans (4.0%). African Americans accounted for a disproportionate percentage of both localized (50% of cases) and generalized (48.9% of cases) DLE. Median CLASI damage scores significantly differed between African Americans, Caucasians, and Asian Americans, at both first (8.5, 4.0, 7.0) (Kruskal-Wallis p<0.0001) and last visit (10.0, 6.0, 8.5) (Kruskal-Wallis p<0.01), (Dunn’s Multiple Comparison p<0.0001, p<0.01). CLASI damage scores in African Americans correlated with CLASI activity scores (Spearman’s r=0.45, p=0.0003). There was no significant correlation between CLASI damage scores and Skindex domains overall. Individually, dyspigmentation and scarring also did not have a significant effect on Quality of Life.
Conclusion: In conclusion, disease damage does not affect quality of life, as measured by the Skindex-29. Differences were found in CLE patients of different races: African American patients with CLE, do exhibit a high rate of DLE, experience damage early in their disease course, frequently in conjunction with disease activity
Disclosure:
S. M. Verma,
None;
J. Okawa,
None;
K. Propert,
None;
V. P. Werth,
None.
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ACR Meeting Abstracts - https://acrabstracts.org/abstract/the-impact-of-dyspigmentation-and-scarring-in-cutaneous-lupus-on-quality-of-life/