Background/Purpose: In Japan, we have a criteria for BD since 1988. (International Journal of Tissue Reactions. 1988: 10; 59-65.) In Japanese patients diagnosed according to this Japanese BD criteria, the recent number of patients with the ocular lesions decreased compared with those with of the passed time; however, those the intestinal lesions increased. Moreover, a new international criteria for Behcet’s disease (ICBD) was proposed in 2006. (Clinical and Experimental Rheumatology. 2006: 24; S13, S14-15.) In ICBD the intestinal lesions were excluded as well as the criteria of international study group (ISG) in 1990 (Lancet. 1990: 335; 1078-80.).The purposes of this study are to analyze the clinical features of BD with comparison among four 5-year-patient groups, and to search which criteria was useful for Japanese BD patients between ISG and ICBD.

Methods: We enrolled our 264 (67.2%) BD patients out of 393. We diagnosed the patients having BD with Japanese BD criteria. We divided our patients to four groups with ones arriving period of 5 years: 49 BD patients were arrived at our clinic and started following until 2000, 70 patients from 2001 to 2005, 77 from 2006 to 2010, and 69 from 2011 to 2015, and compared symptoms of BD among four groups. We then analyzed the escape rate of our Japanese BD patients when we evaluated between ISG and ICBD. Moreover, we compared each rate, which criteria will be more usefull for Japanese BD patients comparing escape rate with chi square test.

Results: The characteristics of our 264 BD patients were as described below: 264 recurrent oral aphtous ulcers (100.0%), 206 genital ulcers (78.0%), 103 ocular manifestations (39.0%), 246 skin manifestations (93.2%), 161 arthritis (61.0%), 7 pathergy tests (2.7%), 71 intestinal lesions (26.9%), 23 neural lesions (8.7%), 22 vascular (8.3%), 11 epidemititis (4.20%), 75 male (28.4%), 136 HLA-B5 (51.5%), 86 HLA-B51 (32.6%), 16 HLA-A26 (6.1%). There was no significant differentiations among periods. The escape rate of our BD patients using ISG was 12.9% (n=34) and that using ICBD was 23.4% (n=15), and statistical analyses showed that ICBD may be useful criteria for Japanese BD patient (chi’s P<0.005: p=0.0044).

Conclusion: The clinical features of our BD patients did not change among four 5-year periods. In our BD patients diagnosed with Japanese BD criteria, the diagnosing criteria for BD called ICBD was better item than ISG.

« Back to 2017 ACR/ARHP Annual Meeting

ACR Meeting Abstracts - https://acrabstracts.org/abstract/the-difference-between-international-criteria-for-bd-icbd-and-the-bd-criteria-of-international-study-group-isg-in-our-behcets-disease-bd-patients-who-fulfilled-japanese-bd-criteria/