ACR Meeting Abstracts

ACR Meeting Abstracts

Abstract Number: 1844

The Contribution of Disease Activity, Depression, and Anxiety to Health-Related and Non-Health-Related Quality of Life in US and Filipino Patients with SLE

Alexandra Watts1, Desiree Azizoddin 2, Shadi Gholizadeh 3, Sarah Mills 4, Geraldine Zamora 5, Daniel Wallace 6, Meenakshi Jolly 7, Michael Weisman 8 and Perry Nicassio 9, 1University of California, Los Angeles, Los Angeles, CA, 2Dana-Farber Cancer Institute, Boston, MA, 3McGill University, Montreal, Canada, 4Lineberger Comprehensive Cancer Center, Chapel Hill, NC, 5Manila Doctors Hospital, Manila, Philippines, 6Cedars-Sinai Medical Center/University California at Los Angeles, Los Angeles, CA, 7Rush University Medical Center, Chicago, IL, 8David Geffen School of Medicine at UCLA, Los Angeles, CA, 9David Geffen School of Medicine, Los Angeles, CA

Meeting: 2019 ACR/ARP Annual Meeting

Keywords: , , ,

Session Information

Date: Monday, November 11, 2019

Title: 4M127: Pain, Anxiety, & Depression (1842–1847)

Session Type: ARP Abstract Session

Session Time: 2:30PM-4:00PM

Background/Purpose: It is well known that patients with SLE are often afflicted with deficits in quality of life and problems with physical impairment and psychosocial functioning. The present study sought to determine the variables associated with both health-related quality of life (HRQOL) and non-health-related quality of life (NHRQOL) in SLE.

Methods: Data from Patients with SLE from medical centers in an urban clinic in the United States and a rural-based clinic in the Philippines were analyzed. The US sample consisted of 136 patients from Los Angeles ages 18-81 (μ=49), and the Filipino sample was comprised of 100 patients ages 19-77 (μ=35) from Manila. Data on demographic factors (illness duration, age, income, and education), along with disease activity depression, anxiety, and quality of life (assessed using LupusPro) were collected. A series of multiple regression analyses were conducted to examine the contribution of demographic factors, disease duration and activity, and psychological factors to health-related quality of life (HRQOL) and non-health related quality of life (NHRQOL) in each sample.

Results: HRQOL. For the US sample, the regression equation was highly significant (F=22.88, p< .001), accounting for 57% of the variance. Anxiety (be=.-32, p< .001) and depression (be=-.46, p< .001) were each associated with lower HRQOL. No other variable was a significant predictor. For the Filipino sample, the regression equation accounted for 16% of the variance (F=2.49, p< .05).   Depression was a significant predictor of lower HRQOL (be=-.28, p< .05). Disease activity (be=.20, p=.06) and anxiety (be=-.19, p=.08) both approached significance. NHRQOL. For the US sample, the regression equation accounted for 19% of the variance in NHRQOL (F=4.16, p< .001). Anxiety individually predicted lower NHRQOL (be=-.28, p< .001), while depression (be=-.16, p=.03) and age (be=-.19, p=.06) approached significance. For the Filipino sample, the regression equation accounted for 10% of the variance in NHRQOL but was not significant (F=1.40, p=.22). Higher income was associated with higher NHRQOL (be=.23, p< .05) but since the overall model was not significant, the importance of income as an individual predictor could not be determined.

Conclusion: The findings illustrated the importance of depression in HRQOL for patients with SLE in the Philippines and the US, and anxiety for patients in the U.S. The results were more robust in general for the Cedars sample. More research on Filipino patients with SLE is needed to identify the predictors and potential intervention targets for quality of life in this population.

Disclosure: A. Watts, None; D. Azizoddin, None; S. Gholizadeh, None; S. Mills, None; G. Zamora, None; D. Wallace, Amgen, 5, 9, Eli Lilly and Co, 9, Eli Lilly and Company, 5, EMD Merck Serono, 5, EMD Serono, 9, Pfizer, 5, 9; M. Jolly, LupusPRO, 7; M. Weisman, AbbVie, 9, Boehringer Ingelheim, 9, Eli Lilly, 5, Lilly, 5, 9, Novartis, 5, Paul Hastings, 9, SetPoint Medical, 9, Takeda, 9, Tharpe & Howell LLP, 9, UCB, 5; P. Nicassio, None.

To cite this abstract in AMA style:

Watts A, Azizoddin D, Gholizadeh S, Mills S, Zamora G, Wallace D, Jolly M, Weisman M, Nicassio P. The Contribution of Disease Activity, Depression, and Anxiety to Health-Related and Non-Health-Related Quality of Life in US and Filipino Patients with SLE [abstract]. Arthritis Rheumatol. 2019; 71 (suppl 10). https://acrabstracts.org/abstract/the-contribution-of-disease-activity-depression-and-anxiety-to-health-related-and-non-health-related-quality-of-life-in-us-and-filipino-patients-with-sle/. Accessed .

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