ACR Meeting Abstracts

ACR Meeting Abstracts

  • Meetings
    • ACR Convergence 2024
    • ACR Convergence 2023
    • 2023 ACR/ARP PRSYM
    • ACR Convergence 2022
    • ACR Convergence 2021
    • ACR Convergence 2020
    • 2020 ACR/ARP PRSYM
    • 2019 ACR/ARP Annual Meeting
    • 2018-2009 Meetings
    • Download Abstracts
  • Keyword Index
  • Advanced Search
  • Your Favorites
    • Favorites
    • Login
    • View and print all favorites
    • Clear all your favorites
  • ACR Meetings

Abstract Number: 1900

The Clinical and the Functional Impact of Central Sensitization on Patients with Axial Spondyloarthritis

Feyza Nur Yücel1 and Mehmet Tuncay Duruöz2, 1Marmara University School of Medicine PMR Department, Istanbul, Turkey, 2Marmara University School of Medicine, PMR Department, Rheumatology Division, Istanbul, Turkey

Meeting: ACR Convergence 2020

Keywords: Ankylosing spondylitis (AS), functional status, pain, quality of life, spondyloarthritis

  • Tweet
  • Click to email a link to a friend (Opens in new window) Email
  • Click to print (Opens in new window) Print
Session Information

Date: Monday, November 9, 2020

Title: Spondyloarthritis Including Psoriatic Arthritis – Diagnosis, Manifestations, & Outcomes Poster III: Axial SpA

Session Type: Poster Session D

Session Time: 9:00AM-11:00AM

Background/Purpose:

To evaluate the impact of central sensitization (CS) on axial spondyloarthritis (AxSpA) patients’ clinical and functional situation and quality of life.

Methods: Subjects with axSpA according to ASAS criteria and healthy controls were recruited. The central sensitization (CS) was evaluated by the central sensitization inventory (CSI). Quantitative sensory testing, which consists of pressure pain threshold (PPT), temporal summation (TS), and conditioned pain modulation (CPM), were applied. The algometer was used in all kinds of pain parameters’ assessment. The spinal hyperalgesia was evaluated from C3 and C7; T6 and T2; L3 and L5 levels. The sacroiliac PPT scores were obtained from 4 points. Trapezius muscle was used to evaluate distant control point. TS scores were evaluated over the trapezius muscle, sacroiliac joints, C7, T6, and L3 spine.  In the evaluation of TS, a  pressure as much the PPT value of each point was applied with pain pressure algometer ten times with a 1-second interstimulus interval. TS  was calculated was by subtracting the rating at 0 seconds from the rating at 10 seconds. For the assessment of conditioned pain modulation (CPM), the first stimulus was applied to trapezius with the pressure that induced a pain intensity of 4/10 points on a VAS. After that, the right hand of the patient was immersed in 7 0C water for 20 seconds to create a conditioning stimulus. The second stimulus was applied to the trapezius.  The ratio between the first and second VAS values was defined as CPM. Disease activity (BASDAI), disability (Istanbul Low Back Pain Disability Index: ILBPDI), quality of life (Ankylosing Spondylitis Quality of Life Questionnaires: ASQoL), sleep quality (Pittsburg Sleep Quality Index: PSQI), VASpain, depression (Beck Depression Inventory: BDI) and fatigue (Fatigue Severity Scale: FSS) were assessed. Comorbidities, fibromyalgia (Fibromyalgia Rapid Screening Tool: FIRST) were noted.

Results: One hundred patients (64 female) and 50 controls (32 female) were recruited. The mean age of patients and healthy controls were 42.31 (SS: 1.0) and 43.64 (SS:1.5), respectively. Central sensitization was detected in 60 of 100 AxSpA patients. When QST results were compared between the patient and control groups, all PPT scores were found lower (p< 0.05) in patients, but there was no significant difference between TS values. Regarding the comparison of the patients with and without CS, sacroiliac, and trapezius PPT scores were found lower in the patients with CS (p< 0.05). On the other hand, there was no significant difference between the groups in the mean measures of the other PPT and TS scores (p >0.05). CPM scores were significantly lower (p=0.048) and BASDAI, ASQoL, BDI, ILBPDI, PSQI, FSS, and FIRST scores were significantly higher (p< 0.001) in the patients with CS (Table). In regression analysis, female gender, morning stiffness duration, CPM, BDI, and FSS scores were detected as related parameters with CSI scores.

Conclusion: Central sensitization is an essential entity in axSpA patients, which affects their clinical and functional situation and quality of daily life negatively. The central sensitization assessment should be taken into consideration to determine the treatment strategy in axSpA patients.


Disclosure: F. Yücel, None; M. Duruöz, None.

To cite this abstract in AMA style:

Yücel F, Duruöz M. The Clinical and the Functional Impact of Central Sensitization on Patients with Axial Spondyloarthritis [abstract]. Arthritis Rheumatol. 2020; 72 (suppl 10). https://acrabstracts.org/abstract/the-clinical-and-the-functional-impact-of-central-sensitization-on-patients-with-axial-spondyloarthritis/. Accessed .
  • Tweet
  • Click to email a link to a friend (Opens in new window) Email
  • Click to print (Opens in new window) Print

« Back to ACR Convergence 2020

ACR Meeting Abstracts - https://acrabstracts.org/abstract/the-clinical-and-the-functional-impact-of-central-sensitization-on-patients-with-axial-spondyloarthritis/

Advanced Search

Your Favorites

You can save and print a list of your favorite abstracts during your browser session by clicking the “Favorite” button at the bottom of any abstract. View your favorites »

All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].

Wiley

  • Online Journal
  • Privacy Policy
  • Permissions Policies
  • Cookie Preferences

© Copyright 2025 American College of Rheumatology