Date: Monday, October 22, 2018
Session Title: Systemic Lupus Erythematosus – Clinical Poster II: Biomarkers and Outcomes
Session Type: ACR Poster Session B
Session Time: 9:00AM-11:00AM
Background/Purpose: Periodontitis is common disease. Recently, it is pointed out that periodontitis was associated with systemic disease. There were a few studies of assessing the relationship between periodontitis and the disease activity of systemic lupus erythematosus(SLE). However, it was unclear that there was evidence to support the relationship. Our hypothesis is that periodontitis is associated with the disease activity of SLE. This study aimed to assess the association between periodontitis and the disease activity of SLE.
Design: A cross-sectional study.
Participants: SLE patients (according to the criteria revised in 1997 by the American College of Rheumatology) who diagnosed at Showa University Hospital, who were under 65-years-old and were collected from June 2016 to December 2016.
Exposure: Our main exposure was periodontitis assessed with
Statistical Analysis: In the main analysis, a multiple regression analysis using the score of SLEDAI-2000 as outcome was conducted to assess the association between periodontitis and the disease activity of SLE with adjustment for age, sex, current smoking status, current prednisolone(PSL) dose, the maximum dose of past PSL treatment and current immunosuppressant therapy. In the secondary analysis, a multiple regression analysis was conducted to analyze the association between periodontitis and the anti-dsDNA antibody level, complement level under the same conditions as above. In multivariable analysis, missing variables were replaced by multiple imputation．
Results: Among 119 SLE patients, mean age was 40.0 years, and 88.2% was female. The prevalence of periodontitis was 69% (1.7% in mild periodontitis, 58.8% in moderate periodontitis, 8.4% in severe periodontitis). Compared with non-periodontitis, the regression coefficients [95% Confident Interval] for SLEDAI of mild periodontitis, moderate periodontitis and severe periodontitis were -4.74 [-11.23 to 1.76], -1.07 [-2.99 to 0.83] and 0.54 [-4.08 to 3.01], respectively. In the secondary analysis, compared with non-periodontitis, the regression coefficients [95%CI] for SLEDAI of severe periodontitis for anti-dsDNA antibody titer was statistically significant (44.6 [7.3-81.9]).
Conclusion: This study demonstrated for the first time in Japan that the prevalence of periodontitis in SLE patients was remarkably high. Our data raise the important possibility that physicians pay attention to periodontitis in SLE practice. Our result did not provide a clear association between periodontitis and the disease activity of SLE. Further studies are needed to test our hypothesis in a longitudinal study in the future.
To cite this abstract in AMA style:Yajima N, Kamitani T, Saito M, Fukuma S, Koide Y, Okamatsu Y, Araki K, Matsuda Y, Fukuhara S. The Association between Periodontitis and the Disease Activity of Systemic Lupus Erythematosus: A Cross-Sectional Study [abstract]. Arthritis Rheumatol. 2018; 70 (suppl 9). https://acrabstracts.org/abstract/the-association-between-periodontitis-and-the-disease-activity-of-systemic-lupus-erythematosus-a-cross-sectional-study/. Accessed March 21, 2023.
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