Session Type: ACR Poster Session C
Session Time: 9:00AM-11:00AM
To assess the relation between Takayasu’s arteritis (TA) and pregnancy outcome.
Methods: This study included 240 pregnancies in 96 patients fulfilling ACR and/or Ishikawa criteria. Obstetrical and maternal outcomes in pregnant women before or concomitant with or after TA diagnosis were analyzed. Factors associated with complicated pregnancy were assessed.
One hundred and forty two pregnancies occurred in 52 patients before TA diagnosis [median age at pregnancy 26 [23-30] years] and 98 pregnancies occurred in 52 patients concomitantly or after TA diagnosis [median age at pregnancy 28 [26-31] years]. Pregnancies concomitant with or after TA diagnosis had 13 times higher rates of obstetrical complications compared to pregnancies before TA diagnosis (OR=13, 95% CI [5-33], p<0.0001). TA was associated with 40% obstetrical complications and include preeclampsia/eclampsia [n=24, (24%)], prematurity [n=8 (8%)] and intrauterine fetal growth restriction or death [n=5 (5%)]. Specific TA complications during pregnancy occurred in 39% and include mainly new onset or worsening hypertension [n=26, (26%)]. In multivariate analysis, smoker (OR=6.15 [1.31-28.8]) and disease activity of TA (i.e. NIH score >1) (OR=28.7 [7.89-104.7]) were independently associated with obstetrical and maternal complications.
TA negatively impacts pregnancy outcomes. Disease activity increases the risk of obstetrical and maternal complications mainly due to arterial hypertension.
To cite this abstract in AMA style:Comarmond C, Mirault T, Biard L, Nizard J, Lambert M, Wechsler B, Hachulla E, Chiche L, Koskas F, Gaudric J, Cluzel P, Messas E, Resche Regon M, Piette JC, Cacoub P, Saadoun D. Takayasu’s Arteritis and Pregnancy [abstract]. Arthritis Rheumatol. 2015; 67 (suppl 10). https://acrabstracts.org/abstract/takayasus-arteritis-and-pregnancy/. Accessed February 25, 2020.
« Back to 2015 ACR/ARHP Annual Meeting
ACR Meeting Abstracts - https://acrabstracts.org/abstract/takayasus-arteritis-and-pregnancy/