ACR Meeting Abstracts

ACR Meeting Abstracts

Abstract Number: 1728

Takayasu’s Arteritis and Pregnancy: A Meta-analysis

Aine Gorman1, Leah Rooney2, Matthew Turk1, Louise Moore3, Jared Bierbrier4, Celine O'Brien5, Anne Clohessy6, Eamonn Molloy7, Lorraine O Neill8, Fionnuala McAuliffe9 and Douglas Veale10, 1St Vincents Hospital, Dublin, Ireland, 2St Vincent's University Hospital, Dublin, Ireland, 3Our Lady's Hospice and Care Services, Harold's Cross, Dublin 6W, Kinnegad, Ireland, 4McMaster University, Hamilton, ON, Canada, 5Perinatal Research Centre, Obstetrics and Gynaecology, School of Medicine, University College Dublin and National Maternity Hospital, Dublin, Dublin, Ireland, 6National Maternity Hopistal, Dublin, Ireland, 7St Vincent's Healthcare Group, Dublin, Ireland, 8St. Vincent's Hospital, Dublin, Ireland, 9National Maternity Hopsital Dublin, Dublin, Ireland, 10University College Dublin, Dublin, Ireland

Meeting: ACR Convergence 2021

Keywords: , , ,

Session Information

Date: Tuesday, November 9, 2021

Title: Reproductive Issues in Rheumatic Disorders Poster (1711–1731)

Session Type: Poster Session D

Session Time: 8:30AM-10:30AM

Background/Purpose: Takayasu’s arteritis is a systemic autoimmune disease characterised by large vessel vasculitis. It usually affects women of childbearing age, with 90% of patients diagnosed < 30 years of age, and previous studies suggest it is associated with adverse pregnancy outcomes. There is a vast discrepancy within the literature; some studies suggest preeclampsia occurring in 4.5% of patients, while others suggest a rate of 61%. The purpose of our work was to determine the prevalence of both maternal and fetal outcomes in patients with Takayasu’s arteritis through a systematic review and meta-analysis.

Methods: We performed a systematic review of the literature using Medline, Web of Science, and the Cochrane library from their inceptions until March 26, 2021, to identify studies that reported pregnancy outcomes in patients with Takayasu’s arteritis. Demographic information, maternal outcomes, foetal outcomes, prednisolone use, and information on disease activity were extracted from studies. Two authors independently selected the studies, extracted the data and assessed for risk of bias.

Results: Our systematic review identified 6638 abstracts, of which 23 articles were included. The miscarriage rate was 11 [7-16] % and an intrauterine death rate of 1[0-3] %. Preeclampsia was reported in 10[7-12] % of patients (Figure 1). Preterm delivery occurred in 15[12-19] %. New hypertension in pregnancy was reported in 12[8-16] %. Intrauterine growth restriction occurred in 16[10-21] % of pregnancies. The prevalence of caesarean sections among Takayasu patients was 28 [22-28] % (Figure 2). In terms of fetal outcomes, low birth weight was associated with 16[10-21] % of live births (Figure 3). Flares of vasculitis occurred in 11[8-15] % of patients.

Conclusion: There is a high prevalence of both maternal and fetal adverse outcomes in pregnant patients with Takayasu’s arteritis, who require careful management by a multidisciplinary team during pregnancy.

Figure 1: Prevalence of preeclampsia in Takayasu’s arteritis patients

Figure 2: Prevalence of caesarean section in Takayasu patients

Figure 3: Prevalence of low birth weight among Takayasu patients

Disclosures: A. Gorman, None; L. Rooney, None; M. Turk, None; L. Moore, None; J. Bierbrier, None; C. O'Brien, None; A. Clohessy, None; E. Molloy, None; L. O Neill, None; F. McAuliffe, None; D. Veale, Abbvie, 1, 5, 6, BMS, 1, 5, Pfizer, 1, 5, 6, Janssen, 1, 5, 6, Eli Lilly, 1, 5, 6, UCB, 1, 5, 6, Novartis, 1, 5, 6, Galapagos/Gilead, 1, 6.

To cite this abstract in AMA style:

Gorman A, Rooney L, Turk M, Moore L, Bierbrier J, O'Brien C, Clohessy A, Molloy E, O Neill L, McAuliffe F, Veale D. Takayasu’s Arteritis and Pregnancy: A Meta-analysis [abstract]. Arthritis Rheumatol. 2021; 73 (suppl 9). https://acrabstracts.org/abstract/takayasus-arteritis-and-pregnancy-a-meta-analysis/. Accessed .

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