Takayasu's Arteritis and Pregnancy - ACR Meeting Abstracts

Cloé Comarmond¹, Tristan Mirault², Lucie Biard³, Jacky Nizard⁴, Marc Lambert⁵, Bertrand Wechsler⁶, Eric Hachulla⁵, Laurent Chiche⁷, Fabien Koskas⁸, Julien Gaudric⁹, Philippe Cluzel¹⁰, Emmanuel Messas¹¹, Mathieu Resche Regon¹², Jean-Charles Piette¹³, Patrice Cacoub¹³ and David Saadoun¹⁴, ¹DHU 2iB Internal Medicine Referal Center for Autoimmune diseases Pitie Hospital, Paris, France, ²Service de Médecine Vasculaire HEGP, Paris, France, ³Biostatistics, Saint-Louis Hospital, Paris, France, ⁴Department of obstetrics and gynaecology, Pitié-Salpêtrière Hospital, Paris, France, ⁵CHU Lille, Lille, France, ⁶Department of Internal Medicine 2. Referal center for SLE/APS, CHU Pitié-Salpêtrière, Paris, France, ⁷Service de Chirurgie Vasculaire, Groupe Hospitalier Pitié-Salpêtrière, Paris, France, ⁸Department of Internal Medicine and 2Laboratory I3 « Immunology, Immunopathology, Immunotherapy », UMR CNRS 7211, INSERM U959, Groupe Hospitalier Pitié-Salpetrière, Université Pierre et Marie Curie, Paris 6, Paris, France, Paris, France, ⁹Department of Vascular surgery GHPS, Paris, France, ¹⁰Cadiovascular Imaging and Interventional Radiology, Pitié-Salpétrière, Paris, France, ¹¹HEGP hospital Vascular and cardiology Department, paris, France, ¹²biostatistics Saint Louis Hospital, paris, France, ¹³Department of Internal Medicine, Pitié-Salpêtrière Hospital, Paris, France, ¹⁴Department of Internal Medicine and clinical Immunology. French National Reference Center for Autoimmune Diseases. DHU I2B (Inflammation, Immunotherapy and Biotherapy), UPMC, Paris VI, Hôpital Pitié Salpétrière, AP-HP, UPMC, Univ Paris 06, Paris, France

Meeting: 2015 ACR/ARHP Annual Meeting

Date of first publication: September 29, 2015

Keywords: Pregnancy and takayasu arteritis

Session Information

Date: Tuesday, November 10, 2015

Title: Vasculitis Poster III

Session Type: ACR Poster Session C

Session Time: 9:00AM-11:00AM

Background/Purpose:

To assess the relation between Takayasu’s arteritis (TA) and pregnancy outcome.

Methods: This study included 240 pregnancies in 96 patients fulfilling ACR and/or Ishikawa criteria. Obstetrical and maternal outcomes in pregnant women before or concomitant with or after TA diagnosis were analyzed. Factors associated with complicated pregnancy were assessed.

Results:

One hundred and forty two pregnancies occurred in 52 patients before TA diagnosis [median age at pregnancy 26 [23-30] years] and 98 pregnancies occurred in 52 patients concomitantly or after TA diagnosis [median age at pregnancy 28 [26-31] years]. Pregnancies concomitant with or after TA diagnosis had 13 times higher rates of obstetrical complications compared to pregnancies before TA diagnosis (OR=13, 95% CI [5-33], p<0.0001). TA was associated with 40% obstetrical complications and include preeclampsia/eclampsia [n=24, (24%)], prematurity [n=8 (8%)] and intrauterine fetal growth restriction or death [n=5 (5%)]. Specific TA complications during pregnancy occurred in 39% and include mainly new onset or worsening hypertension [n=26, (26%)]. In multivariate analysis, smoker (OR=6.15 [1.31-28.8]) and disease activity of TA (i.e. NIH score >1) (OR=28.7 [7.89-104.7]) were independently associated with obstetrical and maternal complications.

Conclusion:

TA negatively impacts pregnancy outcomes. Disease activity increases the risk of obstetrical and maternal complications mainly due to arterial hypertension.

Disclosure: C. Comarmond, None; T. Mirault, None; L. Biard, None; J. Nizard, None; M. Lambert, None; B. Wechsler, None; E. Hachulla, None; L. Chiche, None; F. Koskas, None; J. Gaudric, None; P. Cluzel, None; E. Messas, None; M. Resche Regon, None; J. C. Piette, None; P. Cacoub, None; D. Saadoun, None.

To cite this abstract in AMA style:

Comarmond C, Mirault T, Biard L, Nizard J, Lambert M, Wechsler B, Hachulla E, Chiche L, Koskas F, Gaudric J, Cluzel P, Messas E, Resche Regon M, Piette JC, Cacoub P, Saadoun D. Takayasu’s Arteritis and Pregnancy [abstract]. Arthritis Rheumatol. 2015; 67 (suppl 10). https://acrabstracts.org/abstract/takayasus-arteritis-and-pregnancy/. Accessed .

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