Session Information
Session Title: Biology and Pathology of Bone and Joint (Bone and Arthritis)
Session Type: Abstract Submissions (ACR)
Background/Purpose: Osteocalcin (bone Gla protein), one of the basic markers for bone matabolism, has not been thoroughly studied on patients with DISH and AS. It is a specific product of the osteoblasts, in bones it connects with hydroxyapatite and in the presence of calcium it plays the role of a promoter of the accumulation of calcium in the bone matrix. That’s how osteocalcin takes part in the regulation of bone ossification.
The aim of the study is to estimate the serum levels of osteocalcin on patients with DISH and AS.
Methods: s-OC is estimated on 55 patients with DISH, 25 patients with AS, 50 patients with spondylosis and 15 particularly healthy people aged 55-65, 10 particularly healthy people aged 20-25. The measuring of the s-OC is done by ELISA „sandwitch“ method, with a kit of eBioscience, Austria. The statistic processing is done with SPSS 19 programme (p<0.001) .
Results:
The average measurements of s-OC of patients with DISH and AS are higher in comparison with the results of patients with spondylosis and healthy people, regardless of their age (p<0.05). (table 1)
Table 1: Results of average measurements of s-OC of patients with DISH, spondylosis, AS, young and old controlled in ng/ml
|
Disease |
Number of patients |
|
Referent measurments |
|
|
Min |
Max |
|||
|
DISH |
55 |
6,37±0,619 |
0,80 |
23.90 |
|
Spondylitis |
50 |
1,19±0,024 |
0,70 |
1.90 |
|
AS |
23 |
7,27±1,80 |
0,40 |
41.50 |
|
Young people |
10 |
1,22±0,236 |
0,50 |
3.20 |
|
Old control group |
15 |
1,78±0,226 |
1,20 |
3.60 |
Conclusion: s-OC is significantly increased on patients with DISH and AS in comparison with the results of patients with spondylosis and healthy people, but it is really hard to explain the reason why at the present moment. Hypothetically, this might be a result as a sequence of events, based on which is damage of the spinal cord (stimulation of inflammatory proteins, on-going osteoporosis, compresion fractures, hyperinsulinemia which is a result from metabolic disorders, etc.), the endurance of the vertebrae is decreased and the body increases the production of osteocalcin from the osteoblasts to form compensatory more bone substance. That‘s how the organism adapts to the new changes.
Measuring the levels of serum osteocalcin can be used for early diagnose of DISH due to a difference between the serum levels on patients with DISH and spondylosis, with which differential diagnose is mostly done.
Disclosure:
M. Geneva-Popova,
None;
S. Andreev,
None;
P. Pavlov,
None;
D. Ilev,
None;
S. Popova,
None.
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ACR Meeting Abstracts - https://acrabstracts.org/abstract/study-of-serum-levels-of-osteocalcin-s-oc-on-patients-with-diffuse-idiopathic-skeletal-hyperostosis-dish-and-ankylosing-spondilitis-as/