Session Information
Session Type: Abstract Submissions (ACR)
Soft Drink Intake and Progression of Radiographic Knee Osteoarthritis: Data from the Osteoarthritis Initiative
Background/Purpose : Soft drink consumption has been associated with weight gain and obesity which is a significant risk factor of osteoarthritis (OA), but its role in the progression of OA is unclear. We examine the prospective association of soft drink consumption with radiographic progression of OA.
Methods: In the Osteoarthritis Initiative (OAI), 2149 participants (3066 knees) with radiographic knee OA and having dietary data at baseline were followed up to 12, 24, 36 and 48 months. The frequency of soft drink (not including diet drinks) consumption was assessed with a Block Brief Food Frequency Questionnaire that was completed at baseline. To measure the OA progression, we used the change of a precise quantitative joint space width (JSW) in medial compartment over time between the adjacent bones of the knee based on plain radiographs. The multivariate linear models for repeated measures were used to test the independent association between soft drink intake and the change in JSW over time, while adjusting for Body Mass Index (BMI) and baseline disease severity and potential confounding factors.
Results: In stratified analyses by gender, we observed a significant dose-response relationship between soft drink intake and adjusted mean changes of JSW in men (p trend<0.001) after controlling for BMI and potential confounding factors. With increasing levels of soft drink intake, the mean changes in JSW were 0.29mm, 0.39mm, 0.36mm and 0.59mm respectively. When we further stratified by BMI tertiles, stronger dose-response relationship was found (changes in JSW were 0.21mm, 0.38mm, 0.40mm, 0.75mm respectively) in the lowest BMI tertile (BMI<27.5 kg/m2). In men with BMI ≥27.5 kg/m2, only highest soft drink level (≥5 times/week) was associated with increased JSW compared to no use. By contrast in women, a significant association and dose-response relationship was only observed with the lowest BMI tertile (BMI<27.3 kg/m2, p trend <0.001).
Conclusion: Our results suggest that frequent consumption of soft drinks may be associated with increased OA progression in men. Replication of these novel findings in other prospective studies demonstrating the reduction in soft drink consumption leads to delay in OA progression are needed to test this hypothesis.
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Table. Adjusted mean (SE) changes of Joint Space Width (JSW) by soft drink intake*
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BMI tertiles┼
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Soft drinks, times / week
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Men
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Women
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|
N
|
DJSW, mm*
|
P value
|
P trend
|
N
|
DJSW, mm*
|
P value
|
P trend
|
||
|
Total** |
None |
202
|
0.29(0.03) |
Referent |
|
485
|
0.34(0.02) |
Referent |
|
|
≤1 |
439 |
0.39(0.02)
|
0.012
|
|
537 |
0.37(0.02) |
0.343 |
|
|
|
2-4 |
140 |
0.36(0.04) |
0.191 |
|
145 |
0.40(0.04) |
0.192 |
|
|
|
≥5 |
107 |
0.59(0.05)
|
<0.001
|
<0.001
|
94 |
0.34(0.05) |
0.984 |
0.499 |
|
|
T1 |
None |
62 |
0.21(0.06) |
Referent |
|
181 |
0.29(0.04) |
Referent |
|
|
≤1 |
166 |
0.38(0.04)
|
0.012
|
|
191 |
0.42(0.04) |
0.007
|
|
|
|
2-4 |
38 |
0.40(0.08)
|
0.043
|
|
30 |
0.52(0.08) |
0.009
|
|
|
|
≥5 |
29 |
0.75(0.09)
|
<0.001
|
<0.001
|
17 |
0.41(0.11) |
0.319 |
<0.001
|
|
|
T2 |
None |
62 |
0.30(0.06) |
Referent |
|
168 |
0.38(0.04) |
Referent |
|
|
≤1 |
140 |
0.43(0.04) |
0.076 |
|
170 |
0.31(0.04) |
0.170 |
|
|
|
2-4 |
51 |
0.33(0.07) |
0.733 |
|
51 |
0.40(0.06) |
0.743 |
|
|
|
≥5 |
39 |
0.49(0.08)
|
0.050
|
0.313 |
27 |
0.31(0.09) |
0.465 |
0.713 |
|
|
T3 |
None |
78 |
0.38(0.05) |
Referent |
|
136 |
0.36(0.04) |
Referent |
|
|
≤1 |
133 |
0.39(0.04) |
0.789 |
|
176 |
0.40(0.04) |
0.516 |
|
|
|
2-4 |
51 |
0.38(0.07) |
0.923 |
|
64 |
0.34(0.06) |
0.721 |
|
|
|
≥5 |
39 |
0.62(0.08)
|
0.007
|
0.022
|
50 |
0.35(0.07) |
0.876 |
0.766 |
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* Adjusted for age, race, education, marital status, household income, employment, follow-up time, depression, knee injury and knee surgery, smoking, milk intake, total energy intake, baseline K-L grade and JSW, weight change, the changes of rim distance and beam angle. ** Adjusted for BMI as well ┼ BMI tertiles: Man: T1: <27.5, T2: 27.5-30.8, T3 30.9+; Women: T1: <27.3, T2: 27.3-32.0, T3 32.1+ |
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Disclosure:
B. Lu,
None;
J. Driban,
None;
T. McAlindon,
None;
C. Eaton,
None.
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