Session Type: Poster Session A
Session Time: 8:30AM-10:30AM
Background/Purpose: Sick leave (SL) represents an often poorly studied adverse work outcome especially in early axSpA, with speculation around the potential role of clinical and socioeconomic (SE) factors.
Methods: Patients with a clinical diagnosis of axSpA from the DESIR cohort with work-related data and up to five-year follow-up were studied. Incidence, time to first SL and potential baseline and time-varying predictors were analysed, with a focus on socioeconomic variables (age, gender, ethnicity, education, job-type, marital and parental status). Univariable analyses, followed by collinearity and interaction tests, guided subsequent multivariable time-varying Cox survival model building.
Results: In total, 704 axSpA patients were included (mean (SD) age 33.8 (8.6); 46% male). At baseline, 80% of patients were employed; of these, 5.7% reported being on SL. The distribution of first and recurrent SL episodes over time is shown in Figure 1. The incidence of SL amongst those at risk during the study-period (n=620, 88%) was 0.05 (95% CI 0.03-0.06) per 1000 days of follow-up. Mean (SD) time to first SL was 806 (595) days (range:175-2021 days). In multivariable models, male gender (HR 0.41 (95%CI 0.20-0.86)) and higher education (HR 0.48 (95%CI 0.24-0.95)) were associated with lower hazard of SL, while higher disease activity (HR 1.49 (95%CI 1.04-2.13)), older age, smoking and use of TNFi were associated with higher hazard of SL.
Conclusion: In this early axSpA cohort of young, working-age individuals, male gender and higher education were independently associated with a lower hazard of SL, whereas older age and higher disease activity were associated with higher hazard of SL. The findings suggest a role of socioeconomic factors in adverse work outcomes, alongside active disease.
To cite this abstract in AMA style:Nikiphorou E, Boonen A, CARVALHO P, Fautrel B, Richette P, Machado P, van der Heijde D, Landewé R, Ramiro S. Sick Leave and Its Predictors in Early Axial Spondyloarthritis: The Role of Clinical and Socioeconomic Factors. Five-year Data from the DESIR Cohort [abstract]. Arthritis Rheumatol. 2021; 73 (suppl 9). https://acrabstracts.org/abstract/sick-leave-and-its-predictors-in-early-axial-spondyloarthritis-the-role-of-clinical-and-socioeconomic-factors-five-year-data-from-the-desir-cohort/. Accessed January 27, 2023.
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ACR Meeting Abstracts - https://acrabstracts.org/abstract/sick-leave-and-its-predictors-in-early-axial-spondyloarthritis-the-role-of-clinical-and-socioeconomic-factors-five-year-data-from-the-desir-cohort/