ACR Meeting Abstracts

ACR Meeting Abstracts

Abstract Number: 1053

Severe Joint Injury Assessed by Musculoskeletal Ultrasonography (MSKUS) Predicts the Presence of MRI-Proven Osteitis in Patients with Rheumatoid Arthritis

Shin-ya Kawashiri1, Takahisa Suzuki2, Yoshikazu Nakashima1, Yoshiro Horai3, Naoki Iwamoto3, Kunihiro Ichinose4, Kazuhiko Arima3, Mami Tamai2, Hideki Nakamura5, Tomoki Origuchi6, Kiyoshi Aoyagi7 and Atsushi Kawakami1, 1Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, 2Unit of Translational Medicine, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, 3Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, 4Department of Immunology and Rheumatology, Unit of Translational Medicine, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, 5Department of Immunology and Rheumatology, Nagasaki University, Nagasaki, Japan, 6Department of Health Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, 7Department of Public Health, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan

Meeting: 2012 ACR/ARHP Annual Meeting

Keywords: , ,

Session Information

Title: Imaging of Rheumatic Diseases: Magnetic Resonance Imaging, Computed Tomography and X-ray

Session Type: Abstract Submissions (ACR)

Background/Purpose:

MRI-proven osteitis is known as the prognostic factor toward radiographic progression in patients with rheumatoid arthritis (RA). Musculoskeletal ultrasonography (MSKUS) is another high sensitive imaging modality to find joint injury of RA patients. We have tried to explore whether MSKUS assessment of synovial joint injury predict the presence of MRI-proven osteitis in patients with RA.

Methods:

Thirty RA patients, who fulfilled 2010 RA classification criteria and are naïve to disease-modifying antirheumatic drugs (DMARDs) including biologics or glucocorticoids, are consecutively enrolled in this study from May 2010 through December 2011. Twenty-two joints from each patient including bilateral wrists and finger joints of the 1st – 5th metacarpophalangeal (MCP) joints, the 1st interpharangeal (IP) joint and the 2nd -5th proximal interpharangeal (PIP) joints were examined by both MSKUS and plain MRI. Therefore, a total of 660 joints were investigated by both methods in the present study. Power Doppler (PD) and gray scale (GS) assessment of articular synovitis by a semi-quantitative manner as well as the presence of bone erosion were examined by MSKUS. Plain MRI-proven osteitis was evaluated by RAMRI scoring (RAMRIS) technique. The Cochran-Armitage test was used to investigate a correlation of each MSKUS finding with MRI-proven osteitis.

Results:

The mean disease duration, age, DAS28-ESR, prevalence of RF and anti-cyclic citrullinated peptide antibodies (ACPA) at examination were 4 months, 62 years-old, 5.06, 83.3% and 73.3%, respectively. MSKUS-proven bone erosion was found in 40 sites and MRI-proven osteitis 64 sites, respectively. A remarkable correlation of the PD grade ( p < 0.0001), GS grade ( p < 0.0001) and the presence of MSKUS-proven bone erosion ( p < 0.0001) with the presence of osteitis was demonstrated by the Cochran-Armitage test.

Conclusion:

Our present data suggest that severe joint injury assessed by MSKUS predicts the presence of MRI-proven osteitis in patients with rheumatoid arthritis.

Disclosure:

S. Y. Kawashiri,
None;

T. Suzuki,
None;

Y. Nakashima,
None;

Y. Horai,
None;

N. Iwamoto,
None;

K. Ichinose,
None;

K. Arima,
None;

M. Tamai,
None;

H. Nakamura,
None;

T. Origuchi,
None;

K. Aoyagi,
None;

A. Kawakami,
None.

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