ACR Meeting Abstracts

ACR Meeting Abstracts

Abstract Number: 1274

Severe Flares Are Associated with a Poorer Health-Related Quality of Life (HRQoL) in Systemic Lupus Erythematosus (SLE) Patients

Manuel Ugarte-Gil1, Rocio Gamboa-Cardenas2, Cristina Reategui-Sokolova3, Victor Pimentel-Quiroz1, Mariela Medina4, Claudia Elera-Fitzcarrald2, Francisco Zevallos4, Cesar Pastor-Asurza5, Federico Zazzetti6, Chetan Karyekar7, Risto Perich-Campos5 and Graciela Alarcn8, 1Hospital Guillermo Almenara Irigoyen, Essalud/Universidad Científica del Sur, Lima, Peru, 2Universidad Cientifica del Sur/Hospital Guillermo Almenara Irigoyen. EsSalud, Lima, Peru, 3Hospital Guillermo Almenara Irigoyen, Lima, Peru, 4Hospital Guillermo Almenara Irigoyen. EsSalud, Lima, Peru, 5Universidad Nacional Mayor de San Marcos/Hospital Guillermo Almenara Irigoyen. EsSalud, Lima, Peru, 6Medical Affairs, Jan-Cil Argentina, Buenos Aires, Argentina, 7Janssen R&D, Spring House, PA, 8University of Alabama at Birmingham, Birmingham, AL

Meeting: ACR Convergence 2021

Keywords: , , ,

Session Information

Date: Monday, November 8, 2021

Title: SLE – Diagnosis, Manifestations, & Outcomes Poster III: Outcomes (1257–1303)

Session Type: Poster Session C

Session Time: 8:30AM-10:30AM

Background/Purpose: Flares in SLE patients, regardless of their severity, have been associated with damage accrual. However, their impact on HRQoL has not been fully evaluated. In fact, disease activity is only minimally associated with HRQoL. The aim of this study is to determine the association between flares and HRQoL.

Methods: Patients from the Almenara Lupus Cohort were included. Visits occurring between December 2015 and February 2020 were included. Flares were defined as an increase on the SLEDAI-2K of at least 4 points; severe flares were those with a final SLEDAI-2K higher than 11 and mild-moderate flares all the others. HRQoL was measured using the LupusQoL. Univariable and multivariable generalized estimating regression equations were performed, adjusting for possible confounders. Confounders were determined at one visit whereas the outcome was determined on the subsequent visit; flares were determined based on the variation of the SLEDAI-2K between these visits.

Results: Two hundred and seventy-seven patients were included; 256 (92.4%) were female, mean age at diagnosis was 36.0 (SD: 13.3) and a mean disease duration at baseline was 9.1 (SD: 7.1) years. Patients had mean of 4.8 (SD: 1.9) visits and a mean follow-up of 2.7 (1.1) years. Out of 1098 visits, 115 (10.5%) flares were defined, 17 were severe and 98 mild-moderate. After adjustment for possible confounders, only severe flares were associated with a poorer HRQoL in pain, planning, emotional health and fatigue (table 1).

Conclusion: Severe flares, but not mild-moderate flares are associated with poorer HRQoL.

Disclosures: M. Ugarte-Gil, Pfizer, 5, Janssen, 5; R. Gamboa-Cardenas, None; C. Reategui-Sokolova, Jannsen, 5; V. Pimentel-Quiroz, None; M. Medina, None; C. Elera-Fitzcarrald, None; F. Zevallos, None; C. Pastor-Asurza, None; F. Zazzetti, Janssen, 3; C. Karyekar, Janssen Global Services, LLC, 3, 11; R. Perich-Campos, None; G. Alarcn, None.

To cite this abstract in AMA style:

Ugarte-Gil M, Gamboa-Cardenas R, Reategui-Sokolova C, Pimentel-Quiroz V, Medina M, Elera-Fitzcarrald C, Zevallos F, Pastor-Asurza C, Zazzetti F, Karyekar C, Perich-Campos R, Alarcn G. Severe Flares Are Associated with a Poorer Health-Related Quality of Life (HRQoL) in Systemic Lupus Erythematosus (SLE) Patients [abstract]. Arthritis Rheumatol. 2021; 73 (suppl 9). https://acrabstracts.org/abstract/severe-flares-are-associated-with-a-poorer-health-related-quality-of-life-hrqol-in-systemic-lupus-erythematosus-sle-patients/. Accessed .

« Back to ACR Convergence 2021

ACR Meeting Abstracts - https://acrabstracts.org/abstract/severe-flares-are-associated-with-a-poorer-health-related-quality-of-life-hrqol-in-systemic-lupus-erythematosus-sle-patients/