ACR Meeting Abstracts

ACR Meeting Abstracts

Abstract Number: 694

Serum Wisteria Floribunda Agglutinin-Positive Mac-2-Binding Protein Can Reflect Systemic Lupus Erythematosus Activity

Sung Soo Ahn1, Younhee Park2, Seung Min Jung1, Jason Jungsik Song1, Yong-Beom Park1 and Sang-Won Lee1, 1Division of Rheumatology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea, Republic of (South), 2Department of Laboratory Medicine, Yonsei University College of Medicine, Seoul, Korea, Republic of (South)

Meeting: 2017 ACR/ARHP Annual Meeting

Date of first publication: September 18, 2017

Keywords: , ,

Session Information

Date: Sunday, November 5, 2017

Title: Systemic Lupus Erythematosus – Clinical Aspects and Treatment Poster I: Biomarkers and Outcomes

Session Type: ACR Poster Session A

Session Time: 9:00AM-11:00AM

Abstract Background/Purpose : Serum Mac-2-binding protein (M2BP) is elevated in various chronic inflammatory diseases. Recently, the Wisteria floribunda agglutinin positive-M2BP (WFA+-M2BP) immunoassay has shown promise in detection of highly glycosylated M2BP. We aimed to evaluate the clinical utility of serum M2BP for assessing disease activity of systemic lupus erythematosus (SLE), using the WFA+-M2BP immunoassay. Methods : Serum M2BP was measured in 203 patients with SLE. The associations between SLEDAI-2K and variables was assessed using multivariate linear regression analysis. The relationship between serum M2BP and laboratory variables related to the SLE disease activity index (SLEDAI)-2K and inflammatory burdens was evaluated by Pearson¡¯s correlation analysis. Multivariate logistic regression analysis was used to compare the odds ratios (ORs) of laboratory variables in predicting active SLE. Results : Eighty patients were classified as having active SLE (SLEDAI-2K ¡Ã 5) and 123 patients as having inactive SLE. The median serum M2BP was higher in patients with active SLE than those with inactive SLE (2.1 vs. 0.9, p < 0.001) (Table 1). In multivariate linear regression analysis, serum M2BP, anti-ds DNA, C3, and erythrocyte sedimentation rate were associated with SLEDAI-2K (Table 2). Serum M2BP was strongly correlated with laboratory variables related to SLEDAI-2K and inflammatory burdens, compared to other significant variables. Multivariate logistic regression analysis demonstrated that serum M2BP was more useful in predicting active SLE than other laboratory variables. Conclusion : Serum M2BP can reflect SLE activity and furthermore, it can predict active SLE. We suggest that serum M2BP may be a convenient complementary laboratory tool to SLEDAI-2K in the clinical setting.   References 1. Nielsen CT, et al. Plasma levels of galectin-3-binding protein reflect type I interferon activity and are increased in patients with systemic lupus erythematosus. Lupus Sci Med 2014;1(1):e000026.  

 

 

Disclosure: S. S. Ahn, None; Y. Park, None; S. M. Jung, None; J. J. Song, None; Y. B. Park, None; S. W. Lee, None.

To cite this abstract in AMA style:

Ahn SS, Park Y, Jung SM, Song JJ, Park YB, Lee SW. Serum Wisteria Floribunda Agglutinin-Positive Mac-2-Binding Protein Can Reflect Systemic Lupus Erythematosus Activity [abstract]. Arthritis Rheumatol. 2017; 69 (suppl 10). https://acrabstracts.org/abstract/serum-wisteria-floribunda-agglutinin-positive-mac-2-binding-protein-can-reflect-systemic-lupus-erythematosus-activity/. Accessed .

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