Session Information
Date: Tuesday, November 15, 2016
Session Title: Osteoarthritis – Clinical Aspects - Poster II
Session Type: ACR Poster Session C
Session Time: 9:00AM-11:00AM
Background/Purpose: Due to these sparse and inconsistent clinical data, our current study aims to describe the associations between serum levels of resistin, knee synovial inflammation and structural changes in patients with knee osteoarthritis (OA).
Methods: Patients (n = 200) with symptomatic knee OA (assessed according to American College of Rheumatology criteria) (mean 63.1 years, range 49-79, female 46.5%) participated in this study and all measures were performed at baseline and two years later. Serum levels of resistin were measured using enzyme-linked immunosorbent assay. Infrapatellar fat pad (IPFP) high signal intensity alteration and effusion-synovitis were measured from magnetic resonance imaging (MRI) to represent synovial inflammation. Knee structural changes such as cartilage volume, cartilage defects and bone marrow lesions (BMLs) were assessed in MRI semi-quantitatively or quantitatively. Multilevel mixed-effects liner regression or logistic regression was used in the data analyses.
Results: Serum level of resistin was not significantly associated with age, sex and BMI. It was significantly and positively associated with high signal intensity alteration within IPFP and effusion-synovitis score and volume in univariable and multivariable analyses (Table 1). Additionally, it was significantly and positively associated with total scores of tibiofemoral cartilage defects and BMLs before and after adjustment for co-variables (Table 1). The association between serum levels of resistin and tibial cartilage volume was negative but not significant in multivariable analyses. There were no significant interactions between serum resistin, sex and BMI on synovial inflammation and knee structural change.
Conclusion: Serum levels of resistin were significantly and positively associated with synovial inflammation and knee structural abnormalities, suggesting a potential role of resistin in knee OA. Table 1. The association between resistin and knee structural changes
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Multivariable* β (95% CI) |
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| IPFP signal intensity alteration |
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| Volume (H) (mm3 per ng/ml) |
5.18 (2.24, 8.13) |
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| Percentage (H) (percent per μg/ml) |
0.16 (0.06, 0.26) |
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| Clustering factor (H) (unit per μg/ml) |
7.15 (2.30, 12.00) |
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|
|
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| Effusion-synovitis |
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| Volume (mm3 per ng/ml) |
77.31 (1.17, 153.45) |
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| Presence |
1.06 (1.02, 1.10) |
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| Tibiofemoral cartilage defects (grade per μg/ml) |
19.15 (3.09, 35.22) |
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| Lateral |
9.31 (-1.42, 20.05) |
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| Medial |
10.21 (-0.71, 21.13) |
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| Tibiofemoral BMLs (grade per μg/ml) |
29.69 (7.87, 51.51) |
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| Lateral |
14.56 (4.20, 24.92) |
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| Medial |
11.33 (-3.78, 26.45) |
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*Adjustment for age, sex, BMI, treatment allocation and randomization.
To cite this abstract in AMA style:
HAN W, Cicuttini FM, Jones G, Ding C. Serum Levels of Resistin Are Associated with Synovial Inflammation and Knee Structural Changes in Patients with Symptomatic Knee Osteoarthritis [abstract]. Arthritis Rheumatol. 2016; 68 (suppl 10). https://acrabstracts.org/abstract/serum-levels-of-resistin-are-associated-with-synovial-inflammation-and-knee-structural-changes-in-patients-with-symptomatic-knee-osteoarthritis/. Accessed December 1, 2020.« Back to 2016 ACR/ARHP Annual Meeting
ACR Meeting Abstracts - https://acrabstracts.org/abstract/serum-levels-of-resistin-are-associated-with-synovial-inflammation-and-knee-structural-changes-in-patients-with-symptomatic-knee-osteoarthritis/