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Abstract Number: 807

Serum Cytokine Profiles in Takayasu’s Arteritis: A Search for a Biomarker

Fatma Alibaz-Oner1, P.Sibel Yentür2, Guher Saruhan-Direskeneli3 and Haner Direskeneli1, 1Rheumatology, Marmara University, School of Medicine, Istanbul, Turkey, 2Physiology, Istanbul University, Istanbul Medical Faculty, Istanbul, Turkey, 3Department of Physiology, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey

Meeting: 2014 ACR/ARHP Annual Meeting

Keywords: Cytokines and takayasu arteritis

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Session Information

Session Title: Vasculitis

Session Type: Abstract Submissions (ACR)

Background/Purpose: Assessment of disease activity is one of the main difficulties in patients with Takayasu Arteritis (TAK) during follow-up. In this study, we aimed to investigate serum interleukin (IL)-6, IL-8, IL-10, IL-18, IL-23 and granulocyte-macrophage colony-stimulating factor (GM-CSF), as possible biomarkers of disease activity in patients with TAK.

Methods: The study included 51 patients (age: 40.6±12.2 years, F/M: 45/6) with TAK and 42 age and sex matched healthy controls (age: 38.1±7.4 years, F/M: 38/4). All patients with TAK fulfilled the criteria of American College of Rheumatology (ACR) and were evaluated by physician’s global assessment (PGA: active/inactive) and ITAS2010 (Indian Takayasu  Clinical Activity Score) in terms of clinical activity at baseline and follow-up visits. Commercial enzyme linked immuno-sorbent assay (ELISA) kits were used for the measurements of serum IL-6, IL-8, IL-10, IL-18, IL-23 and GM-CSF. 

Results: At baseline, 21 (41.2%) patients were active assessed with PGA and 8 (15.7%) with ITAS2010. Serum IL-6, IL-8 and IL-18 levels were significantly higher in patients with TAK (TAK vs HC, respectively; 194.7±485 (0-2555) vs 64.3±156.8 (0-748), 49.4±189 (0-1349) vs 8.4±23.8 (0-97), 535.1±252  vs  268.8±216.2) whereas GM-CSF, IL-10 and IL-23 levels were similar to healthy controls. Comparing baseline and follow-up visits, IL-8 levels significantly decreased in follow-up together with a decrease of clinical activity by PGA, whereas IL-23 levels significantly increased. IL-18 levels were associated with disease activity assessed with ITAS2010, but not with PGA. IL-18 was also the only cytokine correlating with CRP. No association of IL-6 levels were observed with disease activity.  

Conclusion: We found significantly increased IL-6, IL-8 and IL-18 levels in patients with TAK compared to healthy controls, suggesting their role in disease pathogenesis. However,  no consistent association of any cytokine is observed with disease activity to use as a biomarker. In addition to anti-IL-6 treatment currently investigated, blockage of other pro-inflammatory cytokines IL-8 and IL-18 might be new therapeutic approaches in refractory TAK.


Disclosure:

F. Alibaz-Oner,
None;

P. S. Yentür,
None;

G. Saruhan-Direskeneli,
None;

H. Direskeneli,
None.

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