Serum CXCL8, 10 and 12 Are Increased in Patients with Behcet's Disease and CXCL10 Levels Are Correlated with Number of Erythema Nodosum

Sang Jin Lee^1,2, Hyun Jung Yoo³, Hyun Mi Kwon⁴, Jin Young Moon⁴, Jin Kyun Park⁵, Eun Young Lee⁵, Eun Bong Lee⁴ and Yeong Wook Song⁵, ¹Division of Rheumatology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea, ²Department of Molecular Medicine and Biopharmaceutical Sciences, BK21 plus Graduate School of Convergence Science and Technology, and College of Medicine or College of Pharmacy, Seoul National University, Seoul, South Korea, ³Department of Molecular Medicine and Biopharmaceutical Sciences, BK 21 plus Graduate School of Convergence Science and Technology, and College of Medicine or College of Parmarcy, Seoul National University, Seoul, South Korea, ⁴Division of Rheumatology, Department of Internal Medicine, Seoul National University Hospital, Seoul, South Korea, ⁵Division of Rheumatology, Department of Internal Medicine, Seoul National University, Seoul, South Korea

Meeting: 2015 ACR/ARHP Annual Meeting

Date of first publication: September 29, 2015

Keywords: Behcet's syndrome, Disease Activity and chemokines

Session Information

Date: Tuesday, November 10, 2015

Title: Vasculitis Poster III

Session Type: ACR Poster Session C

Session Time: 9:00AM-11:00AM

Background/Purpose:

Chemokines are multifunctional mediators that control leukocyte recruitment into the inflammatory sites and enhance immune responses. It remains to be investigated which chemokines are important in Behcet’s disease (BD). The objective of this study was to investigate serum levels of neutrophil and lymphocyte chemoattractants in BD patients and its association with disease activity and symptoms.

Methods:

We collected sera from patients with BD (n=64) and age-, sex matched healthy controls (n=21). Serum levels of chemokines were assayed for the neutrophil chemoattractants (CXCL1 and CXCL8) and lymphocyte chemoattractants (CXCL9, CXCL10, CXCL12, CXCL13 and CXCL16) by using a multiplex assay. Behcet’s disease current activity form (BDCAF) and symptoms were evaluated at the time of blood collection.

Results:

Serum levels of CXCL8, CXCL10 and CXCL12 were significantly higher in the BD patients than in healthy controls (p<0.001, p=0.050 and p=0.002, respectively). Serum chemokine levels were not associated with BDCAF in BD patients. But CXCL10 levels were significantly higher in patients with erythema nodosum (EN) than in patients without EN (p=0.008). AdditionaIly, CXCL10 levels were significantly correlated with number of EN (r=0.338, p=0.006). There was no difference of serum level of CXCL1, CXCL9, CXCL13 and CXCL16 between BD and healthy controls

Conclusion:

Serum levels of CXCL8, CXCL10 and CXCL12 were significantly higher in the BD patients than in healthy controls. CXCL10 levels were correlated with number of EN in BD patients.

Disclosure: S. J. Lee, None; H. J. Yoo, None; H. M. Kwon, None; J. Y. Moon, None; J. K. Park, None; E. Y. Lee, None; E. B. Lee, Pfizer Inc, 5; Y. W. Song, None.

To cite this abstract in AMA style:

Lee SJ, Yoo HJ, Kwon HM, Moon JY, Park JK, Lee EY, Lee EB, Song YW. Serum CXCL8, 10 and 12 Are Increased in Patients with Behcet’s Disease and CXCL10 Levels Are Correlated with Number of Erythema Nodosum [abstract]. Arthritis Rheumatol. 2015; 67 (suppl 10). https://acrabstracts.org/abstract/serum-cxcl8-10-and-12-are-increased-in-patients-with-behcets-disease-and-cxcl10-levels-are-correlated-with-number-of-erythema-nodosum/. Accessed .

« Back to 2015 ACR/ARHP Annual Meeting

ACR Meeting Abstracts - https://acrabstracts.org/abstract/serum-cxcl8-10-and-12-are-increased-in-patients-with-behcets-disease-and-cxcl10-levels-are-correlated-with-number-of-erythema-nodosum/