Session Type: Abstract Submissions (ACR)
Background/Purpose: Numerous data are available in literature on 25 (OH)D serum levels in general population, few and contradictory in Juvenile Idiopathic Arthritis (JIA), and scarce in Juvenile onset Systemic Lupus Erythematosus (JSLE) pts. Our goals are:1- to evaluate the serum 25(OH)D status in a large cohort of JIA and JSLE pts; 2- to correlate the 25(OH)D levels with the variables associated with JIA and JSLE. 3.To compare the pts results with healthy controls.
Methods: 144 JIA pts (122 F, 22 M, median age 15.5 ± 7.2 yrs: 78 oligo, 30 poly, 12 systemic and 24 Entesitis-arthritis [ERA]) onsets, and 46 JSLE pts (38 F, 8M, median age 16.9 ± 6.8 yrs) were studied after informed consent and Ethical approval. In all, serum 25( OH)D, serum intact parathyroid hormone (PTH), calcium, phosphorus, and bone alkaline phosphatase were measured. 100 sex-matched healthy subjects acted as controls.
Results: No significant difference of 25(OH)D levels has been detected in JIA and JSLE pts in comparison to controls as regard the percentage of those with VD deficiency and insufficiency. Of note, in JIA and JSLE pts with deficiency or insufficiency, a significant difference in comparison to controls with deficit or insufficiency, as regard the percentage of subjects with increased PTH and alkaline bone phosphatase levels (p < 0.0001) was detected. In addition, among 25(OH)D levels and JIA subtypes, the lowest levels were found in systemic and poly than in oligo and ERA onsets. Moreover, systmic and poly pts have a significant lower increase of 25 (OH)D levels after supplementation than oligo, ERA pts, and controls with a high percentage of those who remains with insufficiency (p < 0.001). The same results have been observed in JSLE pts who showed a high percentage of insufficiency, despite supplementation, of 25(OH)D than controls. The persistent low 25 (OH)D levels, despite supplementation, are significantly higher in patients with persistent active disease.
Conclusion: Serum 25 (OH) D levels and the percentage with persistent VD insufficiency seem to correlate to type of disease and disease activity. These preliminary results suggest a higher consumption and a higher request of 25(OH)D in patients with active JIA and JSLE.
M. L. Brandi,
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ACR Meeting Abstracts - https://acrabstracts.org/abstract/serum-25ohd-levels-in-adolescents-and-young-adults-with-juvenile-idiopathic-arthritis-and-juvenile-onset-systemic-lupus-erythematosus-prevalence-and-association-with-disease-activity/