SDAI 50 Is More Stringent Than the EULAR Response Measure and a Better Predictor of Low Disease State/Remission in Early Rheumatoid Arthritis: Results from an Early Arthritis Cohort

Mohammed Omair¹, Edward C. Keystone², VP Bykerk³, Boulos Haraoui⁴, Gilles Boire⁵, J Carter Thorne³, Janet E. Pope⁶, Daming Lin⁷, Carol Hitchon⁸ and Pooneh S.Akhavan⁹, ¹Rheumatology, Mount Sinai hospital, Toronto, ON, Canada, ²University of Toronto/Rebecca MacDonald Centre for Arthritis and Autoimmune Disease, Toronto, ON, Canada, ³University of Toronto, Toronto, ON, Canada, ⁴Institut de Rhumatologie de Montréal and University of Montreal, Montreal, QC, Canada, ⁵Department of Medicine/Division of Rheumatology, Université de Sherbrooke, Sherbrooke, QC, Canada, ⁶St. Joseph's Health Care, London, ON, Canada, ⁷mount Sinai Hospital, Toronto, ON, Canada, ⁸University of Manitoba, Winnipeg, MB, Canada, ⁹mount sinai hospital, Toronto, ON, Canada

Meeting: 2015 ACR/ARHP Annual Meeting

Date of first publication: September 29, 2015

Keywords: Prognostic factors and rheumatoid arthritis (RA)

Session Information

Date: Tuesday, November 10, 2015

Title: Rheumatoid Arthritis - Clinical Aspects Poster Session III

Session Type: ACR Poster Session C

Session Time: 9:00AM-11:00AM

Background/Purpose:

To compare the sensitivity of the EULAR and SDAI50 response measures (RMs) and their impact on future response to treatment in patients with early rheumatoid arthritis (RA).

Methods: Biologic naïve RA patients from the Canadian early ArThritis CoHort (CATCH) who had baseline, 3 and 6 months complete data were evaluated. Kappa statistics & Spearman correlation were used to assess the correlation between the EULAR and SDAI50 RMs. The RMs at 3 months were also compared for their ability to predict low disease state (LDAS) or remission (REM) at 6months.

Results: A total of 419 patients were evaluated. Of those, 198 (47.2%) and 206 (49.1%) patients failed to achieve a EULAR and SDAI50 RMs respectively. A strong correlation was observed between the EULAR and SDAI50 RMs with a Kappa of 0.66 (95% CI 0.58- 0.73) and Spearman coefficient of 0.66 (p <0.0001). Throughout the range of disease activity, the SDAI50 response was shown to be more stringent than the EULAR response. Multivariate linear regression analysis demonstrated that SDAI50 at 3 months had a more significant impact on achieving low disease state or remission at 6 months compare to the EULAR response.

Conclusion: Our results suggest there is a strong overall correlation between the EULAR and SDAI50 RMs however a minority of patients can be identified with discordant RMs at the two ends of disease activity spectrum at baseline. Nevertheless the SDAI response at 3 month was a better predictor of outcomes at 6 months than the EULAR response.

Disclosure: M. Omair, Pfizer Inc, 2,Roche Pharmaceuticals, 9,newbridge, 9,Bristol-Myers Squibb, 9; E. C. Keystone, Janssen Inc., 2,Abbott/AbbVie, 5,Amgen, 2,Bristol-Myers Squibb, 5,Janssen Inc., 5,Hoffmann-La Roche, Inc., 5,Janssen Inc., 2,Janssen Inc., 5,Merck Pharmaceuticals, 5,Merck Pharmaceuticals, 5,Pfizer Pharmaceuticals, 5,Pfizer Pharmaceuticals, 5; V. Bykerk, None; B. Haraoui, Abbott, Amgen, BMS, Janssen, Pfizer, Roche and UCB Pharma, 2,Abbott, Amgen, BMS, Janssen, Pfizer, Roche and UCB Pharma, 5,Abbott, Amgen, BMS, Janssen, Pfizer, Roche and UCB Pharma, 8; G. Boire, None; J. C. Thorne, Amgen, Canada, 5; J. E. Pope, None; D. Lin, None; C. Hitchon, None; P. S.Akhavan, None.

To cite this abstract in AMA style:

Omair M, Keystone EC, Bykerk V, Haraoui B, Boire G, Thorne JC, Pope JE, Lin D, Hitchon C, S.Akhavan P. SDAI 50 Is More Stringent Than the EULAR Response Measure and a Better Predictor of Low Disease State/Remission in Early Rheumatoid Arthritis: Results from an Early Arthritis Cohort [abstract]. Arthritis Rheumatol. 2015; 67 (suppl 10). https://acrabstracts.org/abstract/sdai-50-is-more-stringent-than-the-eular-response-measure-and-a-better-predictor-of-low-disease-stateremission-in-early-rheumatoid-arthritis-results-from-an-early-arthritis-cohort/. Accessed .

« Back to 2015 ACR/ARHP Annual Meeting

ACR Meeting Abstracts - https://acrabstracts.org/abstract/sdai-50-is-more-stringent-than-the-eular-response-measure-and-a-better-predictor-of-low-disease-stateremission-in-early-rheumatoid-arthritis-results-from-an-early-arthritis-cohort/