ACR Meeting Abstracts

ACR Meeting Abstracts

  • Home
  • Meetings Archive
    • ACR Convergence 2020
    • 2020 ACR/ARP PRSYM
    • 2019 ACR/ARP Annual Meeting
    • 2018 ACR/ARHP Annual Meeting
    • 2017 ACR/ARHP Annual Meeting
    • 2017 ACR/ARHP PRSYM
    • 2016-2009 Meetings
    • Download Abstracts
  • Keyword Index
  • Advanced Search
  • Your Favorites
    • Favorites
    • Login
    • Register
    • View and print all favorites
    • Clear all your favorites
  • Meeting Resource Center

Abstract Number: 850

Salivary Gland Ultrasonography: A Highly Specific Tool For The Early Diagnosis Of Primary Sjögren’s Syndrome

Nicoletta Luciano1, Chiara Baldini1, Gaia Tarantini2, Rachele Pascale2, Francesca Sernissi1, Linda Carli1, Francesco Ferro1, Rosaria Talarico1, Marta Mosca3, Davide Caramella4 and Stefano Bombardieri1, 1University of Pisa, Rheumatology Unit, Pisa, Italy, 2Department of Diagnostic and Interventional Radiology, University of Pisa, Pisa, Italy, 3Rheumatology Unit, University of Pisa, Pisa, Italy, 4University of Pisa, Department of Diagnostic and Interventional Radiology, University of Pisa, Pisa, Italy

Meeting: 2013 ACR/ARHP Annual Meeting

Keywords: salivary gland and ultrasonography, Sjogren's syndrome

  • Tweet
  • Email
  • Print
Save to PDF
Session Information

Session Title: Imaging of Rheumatic Diseases: Imaging in Vascular and Extra-articular

Session Type: Abstract Submissions (ACR)

Background/Purpose: Recently, Cornec D. et al. reported that salivary gland ultrasonography (SGUS) was characterized by a sensitivity of 65.8% and a specificity of 95.3%, in patients with primary Sjögren’s syndrome (pSS) and a disease duration of  ≤5 years, thus encouraging the use of SGUS for the early diagnosis of pSS. Aims of this study were:1) to validate SGUS diagnostic accuracy in a different cohort of patients with sicca symptoms duration of ≤5 years; 2) to correlate the SGUS score with minor salivary gland biopsy focus score (MSGB/FS) and unstimulated salivary flow rate measured by sialometry.

Methods: Patients with suspected pSS and symptoms duration of ≤5 years were consecutively enrolled in this study. The diagnosis of pSS was made according to the AECG criteria. SGUS was carried out by the same radiologist blinded to the diagnosis and the following US parameters were recorded: size, parenchymal echogenicity and inhomogeneity in the parotid and submandibular glands on both sides. A previously reported ultrasound scoring system (De Vita et al 1992, cut-off≥1) was used to grade the echostructure alterations of the salivary glands. Statistical analysis was performed using SPSS v16. 

Results: This study included 50 patients with pSS and 57 with no-SS sicca symptoms. The mean age of the pSS group was lower than non-SS group (47(13) vs 53(12) yrs, p=0.006).No further differences between the two groups were observed with respect to gender, frequency and duration of dry-mouth and dry-eye related symptoms. Patients with pSS showed a significantly higher SGUS score in comparison with controls (mean (SD)=2.1 (1.8) vs 0.0 (0.4), p=0.000). The SGUS cut-off≥1 showed a sensitivity (SE) of 66%, a specificity (SP) of 98%, a positive predictive value (PPV) of 97% and a negative predictive value (NPV) of 73% for pSS diagnosis. An inverse correlation was observed between the SGUS score and the age of the patients (r=-26, p=0.006) with younger patients frequently presenting multiple hypoechoic areas. The SGUS score was also correlated with both the MSGB/FS (r=55, p=0.000) and the salivary flow rate (r=-40, p=0.000).

Conclusion: This study confirmed the good performance that SGUS for the early non-invasive diagnosis of pSS. Further research in larger international cohort of patients is mandatory in order to assess the role of SGUS in the diagnostic algorithm of pSS.


Disclosure:

N. Luciano,
None;

C. Baldini,
None;

G. Tarantini,
None;

R. Pascale,
None;

F. Sernissi,
None;

L. Carli,
None;

F. Ferro,
None;

R. Talarico,
None;

M. Mosca,
None;

D. Caramella,
None;

S. Bombardieri,
None.

  • Tweet
  • Email
  • Print
Save to PDF

« Back to 2013 ACR/ARHP Annual Meeting

ACR Meeting Abstracts - https://acrabstracts.org/abstract/salivary-gland-ultrasonography-a-highly-specific-tool-for-the-early-diagnosis-of-primary-sjogrens-syndrome/

Advanced Search

Your Favorites

You can save and print a list of your favorite abstracts by clicking the “Favorite” button at the bottom of any abstract. View your favorites »

ACR Convergence: Where Rheumatology Meets. All Virtual. November 5-9.

ACR Pediatric Rheumatology Symposium 2020

© COPYRIGHT 2021 AMERICAN COLLEGE OF RHEUMATOLOGY

Wiley

  • Home
  • Meetings Archive
  • Advanced Search
  • Meeting Resource Center
  • Online Journal
  • Privacy Policy
  • Permissions Policies
loading Cancel
Post was not sent - check your email addresses!
Email check failed, please try again
Sorry, your blog cannot share posts by email.
This site uses cookies: Find out more.