ACR Meeting Abstracts

ACR Meeting Abstracts

Abstract Number: 2225

Role of Fatigue in Difficult to Treat Rheumatoid Arthritis

Maria Rodriguez-Laguna1, Leticia Leon2, Dalifer Freites Nuñez3, Cristina Hormigos-martin4, jose otazu Moudelle4, Alfredo Madrid García5, Benjamin fernandez-Gutierrez2 and lydia Abasolo Alcazar6, 1Resident in Rheumatology, Madrid, Spain, 2Hospital Clinico San Carlos, Madrid, Spain, 3Hospital Clínico San Carlos. Madrid. Spain., Madrid, Spain, 4Hospital Clínico San Carlos, madrid, Spain, 5Fundación para la Investigación Biomédica del Hospital Clínico San Carlos (IDISCC), Madrid, Madrid, Spain, 6IdISSC. HCSC, Madrid, Spain

Meeting: ACR Convergence 2024

Keywords: , ,

Session Information

Date: Monday, November 18, 2024

Title: RA – Diagnosis, Manifestations, & Outcomes Poster III

Session Type: Poster Session C

Session Time: 10:30AM-12:30PM

Background/Purpose: A subset of patients with rheumatoid arthritis (RA) who remains symptomatic after failing to multiple therapies are deemed to have “difficult-to-treat” (D2T RA). Fatigue is a multidimensional and burdensome symptom for RA patients, hindering their improvement. Our purpose was to describe the role of fatigue in D2T RA.

Methods: This cross-sectional study included rheumatoid arthritis (RA) patients between July 2018 and November 2022. All patients met the ACR/EULAR 2010 criteria and they were in treatment with Biological agents or Targeted Synthetic DMARDs. D2T RA was defined based on EULAR criteria. Fatigue was assessed by the Bristol Rheumatoid Arthritis Fatigue Multidimensional Questionnaire (BRAF-MDQ)
and the Bristol Rheumatoid Arthritis Numerical Rating Scales (BRAF-NRS). Covariables: demographic, clinical and treatment. To identify factors independently associated to D2T RA, multivariable logistic regression was applied.

Results: The study population comprised 145 patients, most of them women (66%) and 38 (26.21%%) developed D2T RA. The D2T RA group were older, with more comorbidity and higher disability. Sociodemographic, clinical, disease-related variables, and the fatigue scores used in the study are shown in Table 1. In our final adjusted logistic regression model, global fatigue was independently associated with D2T RA (OR: 1.03; p=0.007). Regarding to different fatigue dimensions our results show that physical fatigue (OR: 1.09; p=0.008)., living fatigue (OR: 1.09; p=0.016), cognitive fatigue (OR: 1.1; p=0.046)  and emotional fatigue (OR: 1.18; p=0.012) were associated with D2T RA.

Conclusion: Despite the absence of an explicit mention of fatigue in the definition of D2T RA, it appears to be associated to this outcome. Fatigue should be evaluated in a multidimensional perspective; and to identify different fatigue patterns in RA patients could be a key to the approach of this complex symptom.

Supporting image 1

Disclosures: M. Rodriguez-Laguna: None; L. Leon: None; D. Freites Nuñez: None; C. Hormigos-martin: None; j. otazu Moudelle: None; A. Madrid García: None; B. fernandez-Gutierrez: None; l. Abasolo Alcazar: None.

To cite this abstract in AMA style:

Rodriguez-Laguna M, Leon L, Freites Nuñez D, Hormigos-martin C, otazu Moudelle j, Madrid García A, fernandez-Gutierrez B, Abasolo Alcazar l. Role of Fatigue in Difficult to Treat Rheumatoid Arthritis [abstract]. Arthritis Rheumatol. 2024; 76 (suppl 9). https://acrabstracts.org/abstract/role-of-fatigue-in-difficult-to-treat-rheumatoid-arthritis/. Accessed .

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